Multiple alignment of complete sequences from BBS6, BBS10 and BBS12 (chaperonin-like) and other chaperonin group II sequences.


The multiple alignment can be viewed using the Jalview applet by clicking on "Start Jalview" and then saved under many different formats.

Multiple alignment
BBS12 and mutations


Help:

- Within the multiple alignment, chaperonin subfamilies are separated by blank sequences using the following format "--[Name of subfamily]--" (ex: "--BBS12--").
- Sequence accession numbers are mostly from UniProt (http://www.uniprot.org) and a few from RefSeq (http://www.ncbi.nih.gov/RefSeq). Predicted sequences from genomes are named using the following format "pred_[Name of subfamily]_[Name of organism]"
    ex: pred_BBS12_Cfamiliaris corresponds to the predicted BBS12 protein sequence for the dog (Canis familiaris)
- The complete list of organisms and their aliases are described here.
- Residues participating in nucleotide binding are highlighted according to interactions with the nucleobase (N), ribose (R), or phosphate groups (P) (Ditzel et al Cell 1998) see line in alignment "--ATPBinding--".
- In the second alignment, point mutations are highlighted in red. If you do not see any red feature please make sure that "feature view" is enabled in the "View" menu.


Please cite us if you use any of this material:

Stoetzel C, Muller J, Laurier V, Davis EE, Zaghloul NA, Vicaire S, Jacquelin C, Plewniak F, Leitch CC, Sarda P, Hamel C, de Ravel TJ, Lewis RA, Friederich E, Thibault C, Danse JM, Verloes A, Bonneau D, Katsanis N, Poch O, Mandel JL, Dollfus H.
Identification of a Novel BBS gene (BBS12) Highlights the Major Role of a Vertebrate-Specific Branch of Chaperonin-Related Proteins in Bardet-Biedl Syndrome.
American Journal of Human Genetics. Jan 2007.


Jalview is available at http://www.jalview.org


Please feel free to contact us for any problem or suggestions (jeanmuller@unistra.fr).

Stoetzel et al (2007) Am J Hum Genet. doi: 10.1086/510256
Stoetzel et al (2006) Nature Genetics doi: 10.1038/ng1771
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