an original or innovative differential conservation analysis
- molecular mapping/cartography of synthetase evolutions at a single residue level
phylogeny -> global evolution history
new formalism : discriminants

objective :
search for specific adaptation signals within synthetases in response to the environment. 
here focus on mitochondrion environment is specific:
- how has been adapted euka type specific seque
- how has been adapted bact type seq
- do the adaptation is the same 


for that , exhaustive search of discriminants in all global environment (euka , bact, archa)
innovative approach will serve has annotation tool, allow to understand the cryptic evolution history (opposed to global history)
Strength is the display/link to 3D structure p
Functional outcomes :
(from seq to struc)
- to identify or recover patterns involved in aa acylation (substrate interacting facade)
- identify/recover patterns involved in oligomerisation
- identify intra-molecular networks/vectors = allosteric functional communication (trans-facade residues)
- identify novel parterns related to unraveles partnerships or function (non interacting facade)

definir discrimant = position (single residues or block or residues) differentially conserved within multiple seq alignment groups