Analysis Type: PANTHER Overrepresentation Test (release 20160715) Annotation Version and Release Date: GO Ontology database Released 2016-06-22 Analyzed List: upload_1 (Saccharomyces cerevisiae) Reference List: Saccharomyces cerevisiae (all genes in database) Bonferroni correction: true GO biological process complete Saccharomyces cerevisiae - REFLIST (6728) upload_1 (455) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (P-value) U1 snRNA 3'-end processing (GO:0034473) 6 6 .41 + 14.79 8.17E-03 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay (GO:0043928) 18 16 1.22 + 13.14 5.41E-10 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' (GO:0034427) 17 15 1.15 + 13.05 3.32E-09 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay (GO:0070478) 17 15 1.15 + 13.05 3.32E-09 proteasomal ubiquitin-independent protein catabolic process (GO:0010499) 14 12 .95 + 12.67 7.68E-07 nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) 19 16 1.28 + 12.45 1.21E-09 polyadenylation-dependent snoRNA 3'-end processing (GO:0071051) 15 11 1.01 + 10.84 2.01E-05 polyadenylation-dependent mRNA catabolic process (GO:0071047) 15 11 1.01 + 10.84 2.01E-05 nuclear polyadenylation-dependent mRNA catabolic process (GO:0071042) 15 11 1.01 + 10.84 2.01E-05 nuclear-transcribed mRNA catabolic process, non-stop decay (GO:0070481) 23 16 1.56 + 10.29 2.01E-08 tRNA catabolic process (GO:0016078) 16 11 1.08 + 10.17 3.86E-05 nuclear polyadenylation-dependent tRNA catabolic process (GO:0071038) 16 11 1.08 + 10.17 3.86E-05 U4 snRNA 3'-end processing (GO:0034475) 15 10 1.01 + 9.86 2.25E-04 nonfunctional rRNA decay (GO:0070651) 21 13 1.42 + 9.15 6.90E-06 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000467) 18 11 1.22 + 9.04 1.25E-04 leading strand elongation (GO:0006272) 12 7 .81 + 8.63 4.20E-02 exonucleolytic trimming involved in rRNA processing (GO:0000459) 19 11 1.28 + 8.56 2.13E-04 nuclear polyadenylation-dependent ncRNA catabolic process (GO:0071046) 20 11 1.35 + 8.13 3.53E-04 nuclear ncRNA surveillance (GO:0071029) 20 11 1.35 + 8.13 3.53E-04 polyadenylation-dependent ncRNA catabolic process (GO:0043634) 20 11 1.35 + 8.13 3.53E-04 nuclear polyadenylation-dependent rRNA catabolic process (GO:0071035) 19 10 1.28 + 7.78 1.88E-03 RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) 21 11 1.42 + 7.75 5.69E-04 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288) 46 24 3.11 + 7.71 6.64E-11 polyadenylation-dependent RNA catabolic process (GO:0043633) 22 11 1.49 + 7.39 8.93E-04 snRNA 3'-end processing (GO:0034472) 20 10 1.35 + 7.39 2.96E-03 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) 31 15 2.10 + 7.15 1.16E-05 rRNA 3'-end processing (GO:0031125) 23 11 1.56 + 7.07 1.37E-03 snRNA processing (GO:0016180) 21 10 1.42 + 7.04 4.54E-03 nuclear mRNA surveillance (GO:0071028) 27 12 1.83 + 6.57 9.26E-04 rRNA catabolic process (GO:0016075) 32 14 2.16 + 6.47 1.26E-04 nuclear RNA surveillance (GO:0071027) 30 13 2.03 + 6.41 4.13E-04 RNA surveillance (GO:0071025) 33 14 2.23 + 6.27 1.83E-04 snoRNA 3'-end processing (GO:0031126) 29 12 1.96 + 6.12 1.94E-03 ncRNA catabolic process (GO:0034661) 35 14 2.37 + 5.91 3.68E-04 nucleotide phosphorylation (GO:0046939) 26 10 1.76 + 5.69 2.86E-02 cellular protein complex localization (GO:0034629) 26 10 1.76 + 5.69 2.86E-02 regulation of translational initiation (GO:0006446) 27 10 1.83 + 5.48 3.92E-02 nucleoside diphosphate metabolic process (GO:0009132) 38 12 2.57 + 4.67 2.88E-02 ncRNA 3'-end processing (GO:0043628) 43 13 2.91 + 4.47 2.02E-02 nuclear-transcribed mRNA catabolic process (GO:0000956) 103 31 6.97 + 4.45 2.01E-08 snoRNA processing (GO:0043144) 44 13 2.98 + 4.37 2.57E-02 mRNA catabolic process (GO:0006402) 105 31 7.10 + 4.37 3.23E-08 pyridine nucleotide metabolic process (GO:0019362) 76 21 5.14 + 4.09 1.86E-04 nicotinamide nucleotide metabolic process (GO:0046496) 75 20 5.07 + 3.94 6.50E-04 pyridine-containing compound metabolic process (GO:0072524) 88 23 5.95 + 3.86 1.22E-04 mRNA-containing ribonucleoprotein complex export from nucleus (GO:0071427) 61 15 4.13 + 3.64 4.78E-02 mRNA export from nucleus (GO:0006406) 61 15 4.13 + 3.64 4.78E-02 chromatin assembly or disassembly (GO:0006333) 66 16 4.46 + 3.58 3.07E-02 mRNA transport (GO:0051028) 91 22 6.15 + 3.57 8.64E-04 RNA catabolic process (GO:0006401) 129 31 8.72 + 3.55 4.36E-06 RNA 3'-end processing (GO:0031123) 71 17 4.80 + 3.54 1.97E-02 oxidoreduction coenzyme metabolic process (GO:0006733) 89 21 6.02 + 3.49 2.30E-03 aging (GO:0007568) 73 17 4.94 + 3.44 2.79E-02 nucleobase-containing compound catabolic process (GO:0034655) 147 33 9.94 + 3.32 6.82E-06 aromatic compound catabolic process (GO:0019439) 166 37 11.23 + 3.30 9.00E-07 RNA localization (GO:0006403) 142 31 9.60 + 3.23 3.84E-05 establishment of RNA localization (GO:0051236) 125 27 8.45 + 3.19 3.93E-04 RNA transport (GO:0050658) 125 27 8.45 + 3.19 3.93E-04 organic cyclic compound catabolic process (GO:1901361) 177 38 11.97 + 3.17 1.45E-06 RNA export from nucleus (GO:0006405) 89 19 6.02 + 3.16 2.94E-02 nucleic acid transport (GO:0050657) 127 27 8.59 + 3.14 5.33E-04 heterocycle catabolic process (GO:0046700) 171 36 11.56 + 3.11 6.80E-06 regulation of cellular amide metabolic process (GO:0034248) 143 30 9.67 + 3.10 1.53E-04 cellular nitrogen compound catabolic process (GO:0044270) 172 36 11.63 + 3.09 7.89E-06 regulation of translation (GO:0006417) 140 29 9.47 + 3.06 3.27E-04 establishment of organelle localization (GO:0051656) 100 20 6.76 + 2.96 4.42E-02 posttranscriptional regulation of gene expression (GO:0010608) 149 29 10.08 + 2.88 1.14E-03 coenzyme metabolic process (GO:0006732) 174 33 11.77 + 2.80 3.38E-04 nucleotide metabolic process (GO:0009117) 215 40 14.54 + 2.75 2.68E-05 nucleobase-containing compound transport (GO:0015931) 151 28 10.21 + 2.74 4.48E-03 nucleocytoplasmic transport (GO:0006913) 164 30 11.09 + 2.70 2.56E-03 nucleoside phosphate metabolic process (GO:0006753) 220 40 14.88 + 2.69 4.94E-05 nuclear transport (GO:0051169) 165 30 11.16 + 2.69 2.88E-03 nucleobase-containing small molecule metabolic process (GO:0055086) 242 44 16.37 + 2.69 9.51E-06 organelle localization (GO:0051640) 140 25 9.47 + 2.64 2.91E-02 monocarboxylic acid metabolic process (GO:0032787) 152 27 10.28 + 2.63 1.46E-02 tRNA metabolic process (GO:0006399) 195 34 13.19 + 2.58 1.45E-03 cofactor metabolic process (GO:0051186) 218 38 14.74 + 2.58 3.19E-04 ribose phosphate metabolic process (GO:0019693) 156 27 10.55 + 2.56 2.30E-02 carboxylic acid biosynthetic process (GO:0046394) 178 30 12.04 + 2.49 1.26E-02 organic acid biosynthetic process (GO:0016053) 185 31 12.51 + 2.48 9.89E-03 mRNA metabolic process (GO:0016071) 301 49 20.36 + 2.41 3.93E-05 cellular macromolecule catabolic process (GO:0044265) 376 61 25.43 + 2.40 6.82E-07 macromolecule catabolic process (GO:0009057) 405 64 27.39 + 2.34 6.76E-07 catabolic process (GO:0009056) 651 100 44.03 + 2.27 1.21E-11 small molecule biosynthetic process (GO:0044283) 289 44 19.54 + 2.25 1.31E-03 cellular catabolic process (GO:0044248) 565 86 38.21 + 2.25 2.46E-09 modification-dependent macromolecule catabolic process (GO:0043632) 237 36 16.03 + 2.25 1.48E-02 oxoacid metabolic process (GO:0043436) 396 60 26.78 + 2.24 1.20E-05 organic substance catabolic process (GO:1901575) 644 97 43.55 + 2.23 1.13E-10 carboxylic acid metabolic process (GO:0019752) 380 57 25.70 + 2.22 4.23E-05 organophosphate metabolic process (GO:0019637) 368 55 24.89 + 2.21 8.64E-05 regulation of cellular protein metabolic process (GO:0032268) 302 45 20.42 + 2.20 1.73E-03 regulation of protein metabolic process (GO:0051246) 310 46 20.96 + 2.19 1.45E-03 organic acid metabolic process (GO:0006082) 420 62 28.40 + 2.18 1.70E-05 small molecule metabolic process (GO:0044281) 733 108 49.57 + 2.18 1.16E-11 oxidation-reduction process (GO:0055114) 418 56 28.27 + 1.98 2.09E-03 chromatin organization (GO:0006325) 322 43 21.78 + 1.97 4.35E-02 single-organism biosynthetic process (GO:0044711) 584 77 39.49 + 1.95 2.80E-05 positive regulation of cellular biosynthetic process (GO:0031328) 373 49 25.23 + 1.94 1.74E-02 phosphorus metabolic process (GO:0006793) 619 81 41.86 + 1.93 1.52E-05 positive regulation of biosynthetic process (GO:0009891) 376 49 25.43 + 1.93 2.15E-02 phosphate-containing compound metabolic process (GO:0006796) 601 77 40.64 + 1.89 9.20E-05 positive regulation of cellular metabolic process (GO:0031325) 459 58 31.04 + 1.87 7.95E-03 positive regulation of metabolic process (GO:0009893) 466 58 31.51 + 1.84 1.25E-02 organic cyclic compound biosynthetic process (GO:1901362) 836 104 56.54 + 1.84 1.03E-06 aromatic compound biosynthetic process (GO:0019438) 791 98 53.49 + 1.83 4.67E-06 chromosome organization (GO:0051276) 529 65 35.78 + 1.82 4.90E-03 organonitrogen compound metabolic process (GO:1901564) 924 113 62.49 + 1.81 3.85E-07 protein transport (GO:0015031) 582 71 39.36 + 1.80 2.03E-03 ribonucleoprotein complex biogenesis (GO:0022613) 480 58 32.46 + 1.79 2.94E-02 heterocycle biosynthetic process (GO:0018130) 793 95 53.63 + 1.77 4.56E-05 ncRNA metabolic process (GO:0034660) 485 58 32.80 + 1.77 3.95E-02 regulation of gene expression (GO:0010468) 862 103 58.30 + 1.77 1.10E-05 regulation of cellular macromolecule biosynthetic process (GO:2000112) 881 105 59.58 + 1.76 8.54E-06 organic cyclic compound metabolic process (GO:1901360) 1880 224 127.14 + 1.76 1.28E-18 macromolecular complex subunit organization (GO:0043933) 806 96 54.51 + 1.76 4.98E-05 establishment of protein localization (GO:0045184) 607 72 41.05 + 1.75 4.57E-03 single-organism metabolic process (GO:0044710) 1292 153 87.38 + 1.75 5.18E-10 cellular aromatic compound metabolic process (GO:0006725) 1826 216 123.49 + 1.75 3.94E-17 regulation of macromolecule biosynthetic process (GO:0010556) 888 105 60.05 + 1.75 1.30E-05 regulation of cellular biosynthetic process (GO:0031326) 914 107 61.81 + 1.73 1.52E-05 regulation of nitrogen compound metabolic process (GO:0051171) 932 109 63.03 + 1.73 1.10E-05 regulation of biosynthetic process (GO:0009889) 917 107 62.01 + 1.73 1.81E-05 nucleobase-containing compound biosynthetic process (GO:0034654) 732 85 49.50 + 1.72 1.11E-03 positive regulation of biological process (GO:0048518) 586 68 39.63 + 1.72 1.87E-02 heterocycle metabolic process (GO:0046483) 1824 211 123.35 + 1.71 2.68E-15 positive regulation of cellular process (GO:0048522) 571 66 38.62 + 1.71 2.91E-02 nucleobase-containing compound metabolic process (GO:0006139) 1752 202 118.48 + 1.70 4.45E-14 macromolecule localization (GO:0033036) 839 96 56.74 + 1.69 3.30E-04 establishment of localization in cell (GO:0051649) 647 74 43.76 + 1.69 1.17E-02 RNA metabolic process (GO:0016070) 1183 134 80.00 + 1.67 7.21E-07 protein localization (GO:0008104) 699 79 47.27 + 1.67 8.31E-03 organonitrogen compound biosynthetic process (GO:1901566) 699 79 47.27 + 1.67 8.31E-03 regulation of macromolecule metabolic process (GO:0060255) 1066 119 72.09 + 1.65 2.51E-05 regulation of cellular metabolic process (GO:0031323) 1085 121 73.38 + 1.65 1.90E-05 nitrogen compound metabolic process (GO:0006807) 2323 259 157.10 + 1.65 3.01E-19 regulation of primary metabolic process (GO:0080090) 1077 120 72.84 + 1.65 2.36E-05 regulation of RNA biosynthetic process (GO:2001141) 715 79 48.35 + 1.63 1.88E-02 regulation of transcription, DNA-templated (GO:0006355) 715 79 48.35 + 1.63 1.88E-02 regulation of nucleic acid-templated transcription (GO:1903506) 715 79 48.35 + 1.63 1.88E-02 biosynthetic process (GO:0009058) 1758 194 118.89 + 1.63 3.54E-11 regulation of metabolic process (GO:0019222) 1109 122 75.00 + 1.63 3.55E-05 organic substance biosynthetic process (GO:1901576) 1721 189 116.39 + 1.62 1.70E-10 regulation of RNA metabolic process (GO:0051252) 732 80 49.50 + 1.62 2.42E-02 cellular biosynthetic process (GO:0044249) 1699 185 114.90 + 1.61 8.93E-10 response to stress (GO:0006950) 744 81 50.32 + 1.61 2.42E-02 metabolic process (GO:0008152) 3510 382 237.37 + 1.61 6.14E-43 cellular nitrogen compound metabolic process (GO:0034641) 2117 230 143.17 + 1.61 4.46E-14 cellular metabolic process (GO:0044237) 3275 354 221.48 + 1.60 5.47E-34 cellular localization (GO:0051641) 805 87 54.44 + 1.60 1.42E-02 organic substance metabolic process (GO:0071704) 3360 360 227.23 + 1.58 1.64E-34 cellular nitrogen compound biosynthetic process (GO:0044271) 1168 125 78.99 + 1.58 1.08E-04 nucleic acid metabolic process (GO:0090304) 1507 161 101.92 + 1.58 4.00E-07 regulation of nucleobase-containing compound metabolic process (GO:0019219) 796 85 53.83 + 1.58 2.89E-02 cellular component biogenesis (GO:0044085) 1071 114 72.43 + 1.57 7.03E-04 primary metabolic process (GO:0044238) 3177 331 214.85 + 1.54 3.57E-25 gene expression (GO:0010467) 1442 145 97.52 + 1.49 2.89E-04 macromolecule metabolic process (GO:0043170) 2541 247 171.84 + 1.44 1.28E-09 cellular macromolecule metabolic process (GO:0044260) 2439 230 164.94 + 1.39 6.43E-07 regulation of cellular process (GO:0050794) 1566 147 105.91 + 1.39 1.34E-02 regulation of biological process (GO:0050789) 1610 151 108.88 + 1.39 9.70E-03 single-organism cellular process (GO:0044763) 3041 274 205.66 + 1.33 1.73E-07 cellular process (GO:0009987) 4774 429 322.86 + 1.33 4.52E-33 single-organism process (GO:0044699) 3266 293 220.87 + 1.33 1.38E-08 biological regulation (GO:0065007) 1888 169 127.68 + 1.32 3.20E-02 cellular component organization or biogenesis (GO:0071840) 2319 206 156.83 + 1.31 2.35E-03 biological_process (GO:0008150) 5929 455 400.97 + 1.13 2.00E-22