PPIF_HUMAN 2019

Gene Name PPIF

Description Peptidyl-prolyl cis-trans isomerase F, mitochondrial

Length 207

9606

Sequence

>sp|P30405|PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F, mitochondrial
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGRTSKKIVITDCGQLS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PPIA_HUMAN

Peptidyl-prolyl cis-trans isomerase A

0.350

SODM_HUMAN

Superoxide dismutase [Mn], mitochondrial

0.383

RFA1_HUMAN

Replication protein A 70 kDa DNA-binding subunit

0.385

TERA_HUMAN

Transitional endoplasmic reticulum ATPase

0.386

PSB1_HUMAN

Proteasome subunit beta type-1

0.386

SYEP_HUMAN

Bifunctional glutamate/proline--tRNA ligase

0.387

SYK_HUMAN

Lysine--tRNA ligase

0.387

MAP2_HUMAN

Methionine aminopeptidase 2

0.387

TCPG_HUMAN

T-complex protein 1 subunit gamma

0.387

PSMD2_HUMAN

26S proteasome non-ATPase regulatory subunit 2

0.387

RAN_HUMAN

GTP-binding nuclear protein Ran

0.388

GARS_HUMAN

Glycine--tRNA ligase

0.388

SYAC_HUMAN

Alanine--tRNA ligase, cytoplasmic

0.388

COPB_HUMAN

Coatomer subunit beta

0.389

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.389

SYLC_HUMAN

Leucine--tRNA ligase, cytoplasmic

0.389

G3P_HUMAN

Glyceraldehyde-3-phosphate dehydrogenase

0.389

XPP1_HUMAN

Xaa-Pro aminopeptidase 1

0.389

G6PI_HUMAN

Glucose-6-phosphate isomerase

0.389

PSA_HUMAN

Puromycin-sensitive aminopeptidase

0.389

SYHC_HUMAN

Histidine--tRNA ligase, cytoplasmic

0.389

PYRG1_HUMAN

CTP synthase 1

0.389

COPB2_HUMAN

Coatomer subunit beta

0.390

PSDE_HUMAN

26S proteasome non-ATPase regulatory subunit 14

0.390

ERCC3_HUMAN

General transcription and DNA repair factor IIH helicase subunit XPB

0.390

ENOA_HUMAN

Alpha-enolase

0.390

BRX1_HUMAN

Ribosome biogenesis protein BRX1 homolog

0.390

DNM1L_HUMAN

Dynamin-1-like protein

0.390

FEN1_HUMAN

Flap endonuclease 1

0.390

RIR1_HUMAN

Ribonucleoside-diphosphate reductase large subunit

0.390

NSF_HUMAN

Vesicle-fusing ATPase

0.390

DPH5_HUMAN

Diphthine methyl ester synthase

0.391

SCFD1_HUMAN

Sec1 family domain-containing protein 1

0.391

MTREX_HUMAN

Exosome RNA helicase MTR4

0.391

RL9_HUMAN

60S ribosomal protein L9

0.391

IPYR_HUMAN

Inorganic pyrophosphatase

0.391

PUM1_HUMAN

Pumilio homolog 1

0.391

SYWC_HUMAN

Tryptophan--tRNA ligase, cytoplasmic

0.391

HDAC2_HUMAN

Histone deacetylase 2

0.391

VPP1_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 1

0.391

TCPZ_HUMAN

T-complex protein 1 subunit zeta

0.391

RS2_HUMAN

40S ribosomal protein S2

0.391

TCPA_HUMAN

T-complex protein 1 subunit alpha

0.392

SYDC_HUMAN

Aspartate--tRNA ligase, cytoplasmic

0.392

VA0D1_HUMAN

V-type proton ATPase subunit d 1

0.392

DIM1_HUMAN

Probable dimethyladenosine transferase

0.392

RIR2_HUMAN

Ribonucleoside-diphosphate reductase subunit M2

0.392

RS8_HUMAN

40S ribosomal protein S8

0.392

BUD23_HUMAN

Probable 18S rRNA (guanine-N(7))-methyltransferase

0.392

RACK1_HUMAN

Receptor of activated protein C kinase 1

0.392

SRPRA_HUMAN

Signal recognition particle receptor subunit alpha

0.392

RSSA_HUMAN

40S ribosomal protein SA

0.392

KPYM_HUMAN

Pyruvate kinase PKM

0.392

NOG1_HUMAN

Nucleolar GTP-binding protein 1

0.392

VATB2_HUMAN

V-type proton ATPase subunit B, brain isoform

0.393

XPO1_HUMAN

Exportin-1

0.393

KRR1_HUMAN

KRR1 small subunit processome component homolog

0.393

COPA_HUMAN

Coatomer subunit alpha

0.393

PSMD7_HUMAN

26S proteasome non-ATPase regulatory subunit 7

0.393

SRP54_HUMAN

Signal recognition particle 54 kDa protein

0.393

VATD_HUMAN

V-type proton ATPase subunit D

0.393

VATA_HUMAN

V-type proton ATPase catalytic subunit A

0.393

OLA1_HUMAN

Obg-like ATPase 1

0.393

UBA1_HUMAN

Ubiquitin-like modifier-activating enzyme 1

0.393

RUSD2_HUMAN

RNA pseudouridylate synthase domain-containing protein 2

0.393

RS6_HUMAN

40S ribosomal protein S6

0.393

TCPD_HUMAN

T-complex protein 1 subunit delta

0.394

NMT1_HUMAN

Glycylpeptide N-tetradecanoyltransferase 1

0.394

PSB7_HUMAN

Proteasome subunit beta type-7

0.394

NMD3_HUMAN

60S ribosomal export protein NMD3

0.394

PRP8_HUMAN

Pre-mRNA-processing-splicing factor 8

0.394

PTPA_HUMAN

Serine/threonine-protein phosphatase 2A activator

0.394

NAT10_HUMAN

RNA cytidine acetyltransferase

0.394

SYIC_HUMAN

Isoleucine--tRNA ligase, cytoplasmic

0.394

RL23_HUMAN

60S ribosomal protein L23

0.394

SYVC_HUMAN

Valine--tRNA ligase

0.394

RFC3_HUMAN

Replication factor C subunit 3

0.394

RL4_HUMAN

60S ribosomal protein L4

0.394

NFS1_HUMAN

Cysteine desulfurase, mitochondrial

0.394

DPOD2_HUMAN

DNA polymerase delta subunit 2

0.394

RLA0_HUMAN

60S acidic ribosomal protein P0

0.394

SYFB_HUMAN

Phenylalanine--tRNA ligase beta subunit

0.394

SYTC_HUMAN

Threonine--tRNA ligase, cytoplasmic

0.394

RS15A_HUMAN

40S ribosomal protein S15a

0.394

PUM2_HUMAN

Pumilio homolog 2

0.395

DNJC2_HUMAN

DnaJ homolog subfamily C member 2

0.395

PGK1_HUMAN

Phosphoglycerate kinase 1

0.395

DDX5_HUMAN

Probable ATP-dependent RNA helicase DDX5

0.395

GDIA_HUMAN

Rab GDP dissociation inhibitor alpha

0.395

PSMD3_HUMAN

26S proteasome non-ATPase regulatory subunit 3

0.395

PSD11_HUMAN

26S proteasome non-ATPase regulatory subunit 11

0.395

PSMD6_HUMAN

26S proteasome non-ATPase regulatory subunit 6

0.395

SC23A_HUMAN

Protein transport protein Sec23A

0.395

MCM2_HUMAN

DNA replication licensing factor MCM2

0.395

RS4X_HUMAN

40S ribosomal protein S4, X isoform

0.395

EIF3I_HUMAN

Eukaryotic translation initiation factor 3 subunit I

0.395

SYQ_HUMAN

Glutamine--tRNA ligase

0.395

CPSF3_HUMAN

Cleavage and polyadenylation specificity factor subunit 3

0.395

DNLI1_HUMAN

DNA ligase 1

0.396

AT131_HUMAN

Manganese-transporting ATPase 13A1

0.396

AAPK2_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-2

0.396

IF6_HUMAN

Eukaryotic translation initiation factor 6

0.396

UBP5_HUMAN

Ubiquitin carboxyl-terminal hydrolase 5

0.396

RCL1_HUMAN

RNA 3-terminal phosphate cyclase-like protein

0.396

LPIN2_HUMAN

Phosphatidate phosphatase LPIN2

0.396

NMT2_HUMAN

Glycylpeptide N-tetradecanoyltransferase 2

0.396

CDS2_HUMAN

Phosphatidate cytidylyltransferase 2

0.397

ABCB7_HUMAN

ATP-binding cassette sub-family B member 7, mitochondrial

0.397

CSK21_HUMAN

Casein kinase II subunit alpha

0.397

PIGA_HUMAN

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

0.397

PSD13_HUMAN

26S proteasome non-ATPase regulatory subunit 13

0.397

RL10A_HUMAN

60S ribosomal protein L10a

0.397

DDX47_HUMAN

Probable ATP-dependent RNA helicase DDX47

0.397

IF2A_HUMAN

Eukaryotic translation initiation factor 2 subunit 1

0.397

SP16H_HUMAN

FACT complex subunit SPT16

0.397

DHDDS_HUMAN

Dehydrodolichyl diphosphate synthase complex subunit DHDDS

0.397

GRP75_HUMAN

Stress-70 protein, mitochondrial

0.397

IMB1_HUMAN

Importin subunit beta-1

0.397

RL7A_HUMAN

60S ribosomal protein L7a

0.397

RBM19_HUMAN

Probable RNA-binding protein 19

0.398

MLH1_HUMAN

DNA mismatch repair protein Mlh1

0.398

RS15_HUMAN

40S ribosomal protein S15

0.398

DHYS_HUMAN

Deoxyhypusine synthase

0.398

RPAC1_HUMAN

DNA-directed RNA polymerases I and III subunit RPAC1

0.398

ERCC2_HUMAN

General transcription and DNA repair factor IIH helicase subunit XPD

0.398

CNOT9_HUMAN

CCR4-NOT transcription complex subunit 9

0.398

SC23B_HUMAN

Protein transport protein Sec23B

0.398

S61A1_HUMAN

Protein transport protein Sec61 subunit alpha isoform 1

0.398

DDX17_HUMAN

Probable ATP-dependent RNA helicase DDX17

0.398

CIAO3_HUMAN

Cytosolic iron-sulfur assembly component 3

0.398

RL21_HUMAN

60S ribosomal protein L21

0.398

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.398

MPPB_HUMAN

Mitochondrial-processing peptidase subunit beta

0.398

PSA5_HUMAN

Proteasome subunit alpha type-5

0.398

PAPD5_HUMAN

Terminal nucleotidyltransferase 4A

0.398

RS14_HUMAN

40S ribosomal protein S14

0.398

RPB3_HUMAN

DNA-directed RNA polymerase II subunit RPB3

0.399

AURKA_HUMAN

Aurora kinase A

0.399

DDX18_HUMAN

ATP-dependent RNA helicase DDX18

0.399

DPOE1_HUMAN

DNA polymerase epsilon catalytic subunit A

0.399

PCNA_HUMAN

Proliferating cell nuclear antigen

0.399

RS5_HUMAN

40S ribosomal protein S5

0.400

DLDH_HUMAN

Dihydrolipoyl dehydrogenase, mitochondrial

0.400

DPH1_HUMAN

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

0.400

RL7_HUMAN

60S ribosomal protein L7

0.400

VATL_HUMAN

V-type proton ATPase 16 kDa proteolipid subunit

0.400

PRI2_HUMAN

DNA primase large subunit

0.400

MCES_HUMAN

mRNA cap guanine-N7 methyltransferase

0.400

AAPK1_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-1

0.400

CNOT1_HUMAN

CCR4-NOT transcription complex subunit 1

0.400

GLYM_HUMAN

Serine hydroxymethyltransferase, mitochondrial

0.400

CRNL1_HUMAN

Crooked neck-like protein 1

0.400

NDKB_HUMAN

Nucleoside diphosphate kinase B

0.400

RAB5A_HUMAN

Ras-related protein Rab-5A

0.400

NLE1_HUMAN

Notchless protein homolog 1

0.400

RS20_HUMAN

40S ribosomal protein S20

0.400

GPN1_HUMAN

GPN-loop GTPase 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 140 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy