TBCC_HUMAN 2019

Gene Name TBCC

Description Tubulin-specific chaperone C

Length 346

9606

Sequence

>sp|Q15814|TBCC_HUMAN Tubulin-specific chaperone C
MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SSF1_HUMAN

Suppressor of SWI4 1 homolog

0.376

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.377

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.379

ISY1_HUMAN

Pre-mRNA-splicing factor ISY1 homolog

0.379

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.383

PFD3_HUMAN

Prefoldin subunit 3

0.384

U2AF5_HUMAN

Splicing factor U2AF 35 kDa subunit-like protein

0.384

U2AF1_HUMAN

Splicing factor U2AF 35 kDa subunit

0.384

SNW1_HUMAN

SNW domain-containing protein 1

0.385

RRP1B_HUMAN

Ribosomal RNA processing protein 1 homolog B

0.388

CLH1_HUMAN

Clathrin heavy chain 1

0.391

H2B1C_HUMAN

Histone H2B type 1-C/E/F/G/I

0.391

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.391

MTOR_HUMAN

Serine/threonine-protein kinase mTOR

0.392

RAB6A_HUMAN

Ras-related protein Rab-6A

0.392

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.393

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.393

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.395

SCYL1_HUMAN

N-terminal kinase-like protein

0.395

VP26B_HUMAN

Vacuolar protein sorting-associated protein 26B

0.395

SF3A3_HUMAN

Splicing factor 3A subunit 3

0.397

TBG1_HUMAN

Tubulin gamma-1 chain

0.397

PSA6_HUMAN

Proteasome subunit alpha type-6

0.397

PLRG1_HUMAN

Pleiotropic regulator 1

0.398

SNAB_HUMAN

Beta-soluble NSF attachment protein

0.398

DBR1_HUMAN

Lariat debranching enzyme

0.398

PSA1_HUMAN

Proteasome subunit alpha type-1

0.398

BOP1_HUMAN

Ribosome biogenesis protein BOP1

0.398

ZN622_HUMAN

Zinc finger protein 622

0.399

RAB7A_HUMAN

Ras-related protein Rab-7a

0.399

H2B1K_HUMAN

Histone H2B type 1-K

0.399

PCID2_HUMAN

PCI domain-containing protein 2

0.399

H2B2F_HUMAN

Histone H2B type 2-F

0.399

H2B1D_HUMAN

Histone H2B type 1-D

0.399

PABP2_HUMAN

Polyadenylate-binding protein 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.356

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.363

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.363

CLPT1_HUMAN

Cleft lip and palate transmembrane protein 1

0.366

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.374

EIF3L_HUMAN

Eukaryotic translation initiation factor 3 subunit L

0.377

AT2A2_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

0.379

NUDC_HUMAN

Nuclear migration protein nudC

0.379

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.381

SND1_HUMAN

Staphylococcal nuclease domain-containing protein 1

0.381

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.381

PIMT_HUMAN

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

0.381

RBM39_HUMAN

RNA-binding protein 39

0.382

RBM8A_HUMAN

RNA-binding protein 8A

0.382

AT2A1_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

0.383

EMC2_HUMAN

ER membrane protein complex subunit 2

0.384

ODBA_HUMAN

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

0.384

CD11B_HUMAN

Cyclin-dependent kinase 11B

0.385

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.386

CTBL1_HUMAN

Beta-catenin-like protein 1

0.387

UCHL5_HUMAN

Ubiquitin carboxyl-terminal hydrolase isozyme L5

0.387

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.387

NDUV2_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

0.389

CATIN_HUMAN

Cactin

0.390

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.390

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.391

COPE_HUMAN

Coatomer subunit epsilon

0.391

C19L2_HUMAN

CWF19-like protein 2

0.391

RL28_HUMAN

60S ribosomal protein L28

0.391

SRP68_HUMAN

Signal recognition particle subunit SRP68

0.391

CD11A_HUMAN

Cyclin-dependent kinase 11A

0.392

KDM8_HUMAN

Bifunctional peptidase and arginyl-hydroxylase JMJD5

0.392

ACLY_HUMAN

ATP-citrate synthase

0.392

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.393

NDUA9_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

0.393

CUL3_HUMAN

Cullin-3

0.393

NDUF7_HUMAN

Protein arginine methyltransferase NDUFAF7, mitochondrial

0.394

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.395

SMYD1_HUMAN

Histone-lysine N-methyltransferase SMYD1

0.395

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.396

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.396

PA2G4_HUMAN

Proliferation-associated protein 2G4

0.396

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.397

NDUV1_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.398

MPU1_HUMAN

Mannose-P-dolichol utilization defect 1 protein

0.398

SNR40_HUMAN

U5 small nuclear ribonucleoprotein 40 kDa protein

0.398

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.398

HTSF1_HUMAN

HIV Tat-specific factor 1

0.398

RBM42_HUMAN

RNA-binding protein 42

0.398

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.399

CSN7A_HUMAN

COP9 signalosome complex subunit 7a

0.399

SF3A1_HUMAN

Splicing factor 3A subunit 1

0.400

MDR3_HUMAN

Phosphatidylcholine translocator ABCB4

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 133 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy