HIKES_HUMAN 2019

Gene Name HIKES

Description Protein Hikeshi

Length 197

9606

Sequence

>sp|Q53FT3|HIKES_HUMAN Protein Hikeshi
MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYESINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSMAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TIPRL_HUMAN

TIP41-like protein

0.382

PIGT_HUMAN

GPI transamidase component PIG-T

0.386

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.396

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.369

NDUA9_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

0.369

NDUV2_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

0.371

NDUV1_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.372

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.372

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.375

NDUF5_HUMAN

Arginine-hydroxylase NDUFAF5, mitochondrial

0.375

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.382

VPS54_HUMAN

Vacuolar protein sorting-associated protein 54

0.385

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.385

AP2M1_HUMAN

AP-2 complex subunit mu

0.388

VPS36_HUMAN

Vacuolar protein-sorting-associated protein 36

0.389

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.389

NDUS8_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

0.390

PA2G4_HUMAN

Proliferation-associated protein 2G4

0.390

TFP11_HUMAN

Tuftelin-interacting protein 11

0.392

EIF3H_HUMAN

Eukaryotic translation initiation factor 3 subunit H

0.392

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.392

NDUF7_HUMAN

Protein arginine methyltransferase NDUFAF7, mitochondrial

0.393

NDUS4_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

0.393

NDUA8_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

0.393

SND1_HUMAN

Staphylococcal nuclease domain-containing protein 1

0.394

GID8_HUMAN

Glucose-induced degradation protein 8 homolog

0.394

NDUS7_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

0.395

ARPC2_HUMAN

Actin-related protein 2/3 complex subunit 2

0.395

SRP68_HUMAN

Signal recognition particle subunit SRP68

0.395

BECN1_HUMAN

Beclin-1

0.396

HTR5B_HUMAN

HEAT repeat-containing protein 5B

0.396

GCH1_HUMAN

GTP cyclohydrolase 1

0.396

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.396

DNJC3_HUMAN

DnaJ homolog subfamily C member 3

0.397

MMSA_HUMAN

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

0.397

NU155_HUMAN

Nuclear pore complex protein Nup155

0.397

MDHM_HUMAN

Malate dehydrogenase, mitochondrial

0.397

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.398

TIPRL_HUMAN

TIP41-like protein

0.398

CB39L_HUMAN

Calcium-binding protein 39-like

0.398

LST8_HUMAN

Target of rapamycin complex subunit LST8

0.398

WDR1_HUMAN

WD repeat-containing protein 1

0.398

SDHA_HUMAN

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

0.399

VPS8_HUMAN

Vacuolar protein sorting-associated protein 8 homolog

0.399

SGPL1_HUMAN

Sphingosine-1-phosphate lyase 1

0.399

CAB39_HUMAN

Calcium-binding protein 39

0.399

RRP12_HUMAN

RRP12-like protein

0.399

PI3R4_HUMAN

Phosphoinositide 3-kinase regulatory subunit 4

0.399

CBS_HUMAN

Cystathionine beta-synthase

0.400

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.400

EXOC5_HUMAN

Exocyst complex component 5

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 129 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy