PQLC1_HUMAN 2019

Gene Name PQLC1

Description PQ-loop repeat-containing protein 1

Length 271

9606

Sequence

>sp|Q8N2U9|PQLC1_HUMAN PQ-loop repeat-containing protein 1
MEAEGLDWLLVPLHQLVSWGAAAAMVFGGVVPYVPQYRDIRRTQNADGFSTYVCLVLLVANILRILFWFGRRFESPLLWQSAIMILTMLLMLKLCTEVRVANELNARRRSFTAADSKDEEVKVAPRRSFLDFDPHHFWQWSSFSDYVQCVLAFTGVAGYITYLSIDSALFVETLGFLAVLTEAMLGVPQLYRNHRHQSTEGMSIKMVLMWTSGDAFKTAYFLLKGAPLQFSVCGLLQVLVDLAILGQAYAFARHPQKPAPHAVHPTGTKAL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GDE_HUMAN

Glycogen debranching enzyme

0.338

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.340

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.340

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.341

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.342

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.343

DPP4_HUMAN

Dipeptidyl peptidase 4

0.343

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.343

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.345

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.346

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.346

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.346

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.346

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.346

VIGLN_HUMAN

Vigilin

0.347

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.347

GOLP3_HUMAN

Golgi phosphoprotein 3

0.349

SOS1_HUMAN

Son of sevenless homolog 1

0.350

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.351

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.351

SEPR_HUMAN

Prolyl endopeptidase FAP

0.351

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.353

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.353

CUL1_HUMAN

Cullin-1

0.354

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.354

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.358

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.358

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.360

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.360

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.361

SURF4_HUMAN

Surfeit locus protein 4

0.363

ZNT1_HUMAN

Zinc transporter 1

0.363

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.365

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.367

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.368

PBDC1_HUMAN

Protein PBDC1

0.369

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.369

CACP_HUMAN

Carnitine O-acetyltransferase

0.370

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.370

COR1C_HUMAN

Coronin-1C

0.371

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.371

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.372

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.372

SEPT7_HUMAN

Septin-7

0.373

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.374

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.374

SOS2_HUMAN

Son of sevenless homolog 2

0.375

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.375

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.375

S39A9_HUMAN

Zinc transporter ZIP9

0.376

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.376

DOP1_HUMAN

Protein dopey-1

0.377

NPRL2_HUMAN

GATOR complex protein NPRL2

0.377

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.378

STRP1_HUMAN

Striatin-interacting protein 1

0.378

S2536_HUMAN

Solute carrier family 25 member 36

0.379

SNX12_HUMAN

Sorting nexin-12

0.379

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.379

HIP1_HUMAN

Huntingtin-interacting protein 1

0.379

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.380

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.380

RHOA_HUMAN

Transforming protein RhoA

0.381

H33_HUMAN

Histone H3.3

0.381

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.381

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.381

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.382

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.382

DYR_HUMAN

Dihydrofolate reductase

0.382

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.383

SNX3_HUMAN

Sorting nexin-3

0.383

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.384

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.384

TBC20_HUMAN

TBC1 domain family member 20

0.385

MIO_HUMAN

GATOR complex protein MIOS

0.385

ARGI2_HUMAN

Arginase-2, mitochondrial

0.385

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.386

S2533_HUMAN

Solute carrier family 25 member 33

0.386

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.387

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.387

SRF_HUMAN

Serum response factor

0.387

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.387

DOP2_HUMAN

Protein dopey-2

0.390

PB1_HUMAN

Protein polybromo-1

0.390

GATA4_HUMAN

Transcription factor GATA-4

0.391

PAXI_HUMAN

Paxillin

0.392

CLAT_HUMAN

Choline O-acetyltransferase

0.392

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.393

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.394

K1109_HUMAN

Transmembrane protein KIAA1109

0.394

M3K4_HUMAN

Mitogen-activated protein kinase kinase kinase 4

0.394

LIPT_HUMAN

Lipoyltransferase 1, mitochondrial

0.395

MOT12_HUMAN

Monocarboxylate transporter 12

0.395

CEGT_HUMAN

Ceramide glucosyltransferase

0.395

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.395

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.395

DIC_HUMAN

Mitochondrial dicarboxylate carrier

0.396

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.396

RCC1_HUMAN

Regulator of chromosome condensation

0.396

MK14_HUMAN

Mitogen-activated protein kinase 14

0.396

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.397

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.397

CORO6_HUMAN

Coronin-6

0.397

HID1_HUMAN

Protein HID1

0.397

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.398

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.399

LMA2L_HUMAN

VIP36-like protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 89 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy