ARL8A_HUMAN 2019

Gene Name ARL8A

Description ADP-ribosylation factor-like protein 8A

Length 186

9606

Sequence

>sp|Q96BM9|ARL8A_HUMAN ADP-ribosylation factor-like protein 8A
MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQLQGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

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What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ARL8B_HUMAN

ADP-ribosylation factor-like protein 8B

0.241

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ARL8B_HUMAN

ADP-ribosylation factor-like protein 8B

0.234

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.346

ACLY_HUMAN

ATP-citrate synthase

0.351

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.354

ACSF2_HUMAN

Acyl-CoA synthetase family member 2, mitochondrial

0.358

KDM8_HUMAN

Bifunctional peptidase and arginyl-hydroxylase JMJD5

0.360

GCDH_HUMAN

Glutaryl-CoA dehydrogenase, mitochondrial

0.363

MCCB_HUMAN

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

0.364

AT2A2_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

0.364

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.366

CLPT1_HUMAN

Cleft lip and palate transmembrane protein 1

0.366

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.366

ODBA_HUMAN

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

0.367

EIF3L_HUMAN

Eukaryotic translation initiation factor 3 subunit L

0.368

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.369

PIMT_HUMAN

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

0.370

RBM39_HUMAN

RNA-binding protein 39

0.370

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.370

CSN7A_HUMAN

COP9 signalosome complex subunit 7a

0.371

IVD_HUMAN

Isovaleryl-CoA dehydrogenase, mitochondrial

0.371

NUDC_HUMAN

Nuclear migration protein nudC

0.371

NDUV2_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

0.373

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.373

NDUA9_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

0.374

AT2A3_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

0.374

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.375

NDUV1_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.376

ODBB_HUMAN

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

0.378

AT2A1_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

0.378

GPTC1_HUMAN

G patch domain-containing protein 1

0.379

CATIN_HUMAN

Cactin

0.379

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.379

CHRD1_HUMAN

Cysteine and histidine-rich domain-containing protein 1

0.379

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.379

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.381

PPIL1_HUMAN

Peptidyl-prolyl cis-trans isomerase-like 1

0.382

DNJC3_HUMAN

DnaJ homolog subfamily C member 3

0.384

VTA1_HUMAN

Vacuolar protein sorting-associated protein VTA1 homolog

0.385

CC130_HUMAN

Coiled-coil domain-containing protein 130

0.385

C19L2_HUMAN

CWF19-like protein 2

0.386

AP2M1_HUMAN

AP-2 complex subunit mu

0.386

CSN3_HUMAN

COP9 signalosome complex subunit 3

0.388

RBM8A_HUMAN

RNA-binding protein 8A

0.388

CTBL1_HUMAN

Beta-catenin-like protein 1

0.389

THOC1_HUMAN

THO complex subunit 1

0.390

MMSA_HUMAN

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

0.390

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.390

CD11B_HUMAN

Cyclin-dependent kinase 11B

0.390

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.390

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.391

NDUS8_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

0.391

HCDH_HUMAN

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

0.391

CHDH_HUMAN

Choline dehydrogenase, mitochondrial

0.392

SND1_HUMAN

Staphylococcal nuclease domain-containing protein 1

0.392

TFP11_HUMAN

Tuftelin-interacting protein 11

0.393

LACB2_HUMAN

Endoribonuclease LACTB2

0.393

SCPDL_HUMAN

Saccharopine dehydrogenase-like oxidoreductase

0.393

RANB9_HUMAN

Ran-binding protein 9

0.393

NDUS7_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

0.393

COPE_HUMAN

Coatomer subunit epsilon

0.394

EMC2_HUMAN

ER membrane protein complex subunit 2

0.395

RAC1_HUMAN

Ras-related C3 botulinum toxin substrate 1

0.395

3HIDH_HUMAN

3-hydroxyisobutyrate dehydrogenase, mitochondrial

0.395

DDB1_HUMAN

DNA damage-binding protein 1

0.395

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.395

AGO2_HUMAN

Protein argonaute-2

0.395

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.395

NDUF5_HUMAN

Arginine-hydroxylase NDUFAF5, mitochondrial

0.396

RAC2_HUMAN

Ras-related C3 botulinum toxin substrate 2

0.397

MGN2_HUMAN

Protein mago nashi homolog 2

0.397

CD11A_HUMAN

Cyclin-dependent kinase 11A

0.397

HEXB_HUMAN

Beta-hexosaminidase subunit beta

0.397

NDUS4_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

0.397

SC16A_HUMAN

Protein transport protein Sec16A

0.398

SGPL1_HUMAN

Sphingosine-1-phosphate lyase 1

0.398

VPS36_HUMAN

Vacuolar protein-sorting-associated protein 36

0.398

EIF3H_HUMAN

Eukaryotic translation initiation factor 3 subunit H

0.398

VPS51_HUMAN

Vacuolar protein sorting-associated protein 51 homolog

0.398

STK38_HUMAN

Serine/threonine-protein kinase 38

0.398

FA50A_HUMAN

Protein FAM50A

0.399

HMGC2_HUMAN

3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

0.399

NDUF7_HUMAN

Protein arginine methyltransferase NDUFAF7, mitochondrial

0.400

SYF2_HUMAN

Pre-mRNA-splicing factor SYF2

0.400

AGO1_HUMAN

Protein argonaute-1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 131 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy