MET2A_HUMAN 2019

Gene Name MET2A

Description Methyltransferase-like protein 2A

Length 378

9606

Sequence

>sp|Q96IZ6|MET2A_HUMAN Methyltransferase-like protein 2A
MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MET2B_HUMAN

Methyltransferase-like protein 2B

0.307

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MET2B_HUMAN

Methyltransferase-like protein 2B

0.101

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.347

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.349

SEPT7_HUMAN

Septin-7

0.350

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.352

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.355

H33_HUMAN

Histone H3.3

0.355

VIGLN_HUMAN

Vigilin

0.356

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.358

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.359

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.361

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.361

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.361

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.361

CUL1_HUMAN

Cullin-1

0.362

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.362

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.365

RCC1_HUMAN

Regulator of chromosome condensation

0.365

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.365

DOP1_HUMAN

Protein dopey-1

0.366

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.368

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.371

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.371

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.373

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.374

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.374

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.375

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.375

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.376

GOLP3_HUMAN

Golgi phosphoprotein 3

0.377

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.377

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.377

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.378

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.378

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.378

CCHL_HUMAN

Cytochrome c-type heme lyase

0.379

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.380

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.381

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.382

DOP2_HUMAN

Protein dopey-2

0.382

VP13A_HUMAN

Vacuolar protein sorting-associated protein 13A

0.382

STT3B_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

0.382

TBC20_HUMAN

TBC1 domain family member 20

0.383

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.383

NPRL2_HUMAN

GATOR complex protein NPRL2

0.384

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.384

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.386

SOS1_HUMAN

Son of sevenless homolog 1

0.386

COR1C_HUMAN

Coronin-1C

0.387

S2533_HUMAN

Solute carrier family 25 member 33

0.387

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.388

RHOA_HUMAN

Transforming protein RhoA

0.388

GDE_HUMAN

Glycogen debranching enzyme

0.388

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.388

SURF4_HUMAN

Surfeit locus protein 4

0.389

DPP4_HUMAN

Dipeptidyl peptidase 4

0.389

CPSF4_HUMAN

Cleavage and polyadenylation specificity factor subunit 4

0.389

LBR_HUMAN

Delta(14)-sterol reductase

0.389

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.390

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.390

TCPD_HUMAN

T-complex protein 1 subunit delta

0.391

S2536_HUMAN

Solute carrier family 25 member 36

0.391

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.392

HXK4_HUMAN

Glucokinase

0.392

SRF_HUMAN

Serum response factor

0.393

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.394

PIGA_HUMAN

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

0.394

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.394

KDM4A_HUMAN

Lysine-specific demethylase 4A

0.394

GATA4_HUMAN

Transcription factor GATA-4

0.394

HIP1_HUMAN

Huntingtin-interacting protein 1

0.395

DDX3X_HUMAN

ATP-dependent RNA helicase DDX3X

0.395

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.395

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.396

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.396

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.396

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.397

DNJC2_HUMAN

DnaJ homolog subfamily C member 2

0.397

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.397

RFA1_HUMAN

Replication protein A 70 kDa DNA-binding subunit

0.397

KDM4C_HUMAN

Lysine-specific demethylase 4C

0.397

HID1_HUMAN

Protein HID1

0.397

CRNL1_HUMAN

Crooked neck-like protein 1

0.397

XPO1_HUMAN

Exportin-1

0.397

PSDE_HUMAN

26S proteasome non-ATPase regulatory subunit 14

0.397

ZNT1_HUMAN

Zinc transporter 1

0.398

GATA6_HUMAN

Transcription factor GATA-6

0.398

ERO1B_HUMAN

ERO1-like protein beta

0.398

PCID2_HUMAN

PCI domain-containing protein 2

0.398

ATPA_HUMAN

ATP synthase subunit alpha, mitochondrial

0.398

TERA_HUMAN

Transitional endoplasmic reticulum ATPase

0.398

GARS_HUMAN

Glycine--tRNA ligase

0.398

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.398

UBE4B_HUMAN

Ubiquitin conjugation factor E4 B

0.398

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.398

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.398

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.399

HXK1_HUMAN

Hexokinase-1

0.399

PSB1_HUMAN

Proteasome subunit beta type-1

0.399

PSB7_HUMAN

Proteasome subunit beta type-7

0.399

NAT10_HUMAN

RNA cytidine acetyltransferase

0.399

SEPR_HUMAN

Prolyl endopeptidase FAP

0.399

SOS2_HUMAN

Son of sevenless homolog 2

0.399

SYDC_HUMAN

Aspartate--tRNA ligase, cytoplasmic

0.399

SYTC_HUMAN

Threonine--tRNA ligase, cytoplasmic

0.399

C560_HUMAN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

0.399

RL7_HUMAN

60S ribosomal protein L7

0.399

SYEP_HUMAN

Bifunctional glutamate/proline--tRNA ligase

0.399

COPB2_HUMAN

Coatomer subunit beta

0.399

PLCA_HUMAN

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

0.399

NOG1_HUMAN

Nucleolar GTP-binding protein 1

0.400

EBP2_HUMAN

Probable rRNA-processing protein EBP2

0.400

CISY_HUMAN

Citrate synthase, mitochondrial

0.400

IDE_HUMAN

Insulin-degrading enzyme

0.400

RIR1_HUMAN

Ribonucleoside-diphosphate reductase large subunit

0.400

SC23A_HUMAN

Protein transport protein Sec23A

0.400

PSD11_HUMAN

26S proteasome non-ATPase regulatory subunit 11

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 115 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy