OXSM_HUMAN 2019

Gene Name OXSM

Description 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Length 459

9606

Sequence

>sp|Q9NWU1|OXSM_HUMAN 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
MSNCLQNFLKITSTRLLCSRLCQQLRSKRKFFGTVPISRLHRRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQFNEQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSTNSDPKLACRPFHPKRDGFVMGEGAAVLVLEEYEHAVQRRARIYAEVLGYGLSGDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIGLTNSFGFGGTNATLCIAGL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

EFTU_HUMAN

Elongation factor Tu, mitochondrial

0.317

FABD_HUMAN

Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

0.318

RF1ML_HUMAN

Peptide chain release factor 1-like, mitochondrial

0.322

CLPX_HUMAN

ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

0.322

MOD5_HUMAN

tRNA dimethylallyltransferase

0.322

SYLM_HUMAN

Probable leucine--tRNA ligase, mitochondrial

0.325

SYWM_HUMAN

Tryptophan--tRNA ligase, mitochondrial

0.328

EFGM_HUMAN

Elongation factor G, mitochondrial

0.330

RM03_HUMAN

39S ribosomal protein L3, mitochondrial

0.331

RM13_HUMAN

39S ribosomal protein L13, mitochondrial

0.332

SYYM_HUMAN

Tyrosine--tRNA ligase, mitochondrial

0.333

RT09_HUMAN

28S ribosomal protein S9, mitochondrial

0.335

GUF1_HUMAN

Translation factor GUF1, mitochondrial

0.336

IF2M_HUMAN

Translation initiation factor IF-2, mitochondrial

0.345

CH60_HUMAN

60 kDa heat shock protein, mitochondrial

0.346

RM04_HUMAN

39S ribosomal protein L4, mitochondrial

0.346

RF1M_HUMAN

Peptide chain release factor 1, mitochondrial

0.350

ATPB_HUMAN

ATP synthase subunit beta, mitochondrial

0.354

MAP11_HUMAN

Methionine aminopeptidase 1

0.356

PLPHP_HUMAN

Pyridoxal phosphate homeostasis protein

0.358

SYEM_HUMAN

Probable glutamate--tRNA ligase, mitochondrial

0.359

ATPG_HUMAN

ATP synthase subunit gamma, mitochondrial

0.359

ACPM_HUMAN

Acyl carrier protein, mitochondrial

0.360

RRP5_HUMAN

Protein RRP5 homolog

0.361

CH10_HUMAN

10 kDa heat shock protein, mitochondrial

0.362

MTG2_HUMAN

Mitochondrial ribosome-associated GTPase 2

0.362

TACO1_HUMAN

Translational activator of cytochrome c oxidase 1

0.365

CLPP_HUMAN

ATP-dependent Clp protease proteolytic subunit, mitochondrial

0.367

FOLC_HUMAN

Folylpolyglutamate synthase, mitochondrial

0.370

ATPA_HUMAN

ATP synthase subunit alpha, mitochondrial

0.372

RPA2_HUMAN

DNA-directed RNA polymerase I subunit RPA2

0.374

KGUA_HUMAN

Guanylate kinase

0.374

RPE_HUMAN

Ribulose-phosphate 3-epimerase

0.377

RM17_HUMAN

39S ribosomal protein L17, mitochondrial

0.384

RM27_HUMAN

39S ribosomal protein L27, mitochondrial

0.386

OSGP2_HUMAN

Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial

0.386

MTU1_HUMAN

Mitochondrial tRNA-specific 2-thiouridylase 1

0.387

SYDM_HUMAN

Aspartate--tRNA ligase, mitochondrial

0.387

METK2_HUMAN

S-adenosylmethionine synthase isoform type-2

0.388

RPA1_HUMAN

DNA-directed RNA polymerase I subunit RPA1

0.388

RT16_HUMAN

28S ribosomal protein S16, mitochondrial

0.391

EFTS_HUMAN

Elongation factor Ts, mitochondrial

0.391

METK1_HUMAN

S-adenosylmethionine synthase isoform type-1

0.392

RPEL1_HUMAN

Ribulose-phosphate 3-epimerase-like protein 1

0.396

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SERB_HUMAN

Phosphoserine phosphatase

0.292

NEMF_HUMAN

Nuclear export mediator factor NEMF

0.294

ECM29_HUMAN

Proteasome adapter and scaffold protein ECM29

0.303

SYLM_HUMAN

Probable leucine--tRNA ligase, mitochondrial

0.314

PCY2_HUMAN

Ethanolamine-phosphate cytidylyltransferase

0.316

UBXN7_HUMAN

UBX domain-containing protein 7

0.328

WDR44_HUMAN

WD repeat-containing protein 44

0.336

ASCC3_HUMAN

Activating signal cointegrator 1 complex subunit 3

0.347

KIME_HUMAN

Mevalonate kinase

0.351

LMBD2_HUMAN

LMBR1 domain-containing protein 2

0.351

HPPD_HUMAN

4-hydroxyphenylpyruvate dioxygenase

0.355

DIP2B_HUMAN

Disco-interacting protein 2 homolog B

0.356

STML2_HUMAN

Stomatin-like protein 2, mitochondrial

0.358

THADA_HUMAN

Thyroid adenoma-associated protein

0.362

DIP2C_HUMAN

Disco-interacting protein 2 homolog C

0.363

TPC_HUMAN

Mitochondrial thiamine pyrophosphate carrier

0.364

ERCC6_HUMAN

DNA excision repair protein ERCC-6

0.364

GPCP1_HUMAN

Glycerophosphocholine phosphodiesterase GPCPD1

0.369

DIP2A_HUMAN

Disco-interacting protein 2 homolog A

0.370

NGLY1_HUMAN

Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

0.370

AQR_HUMAN

RNA helicase aquarius

0.374

CLU_HUMAN

Clustered mitochondria protein homolog

0.375

GMPPB_HUMAN

Mannose-1-phosphate guanyltransferase beta

0.378

MRM1_HUMAN

rRNA methyltransferase 1, mitochondrial

0.380

TRIP4_HUMAN

Activating signal cointegrator 1

0.381

ZN363_HUMAN

RING finger and CHY zinc finger domain-containing protein 1

0.381

MED7_HUMAN

Mediator of RNA polymerase II transcription subunit 7

0.384

UBE3B_HUMAN

Ubiquitin-protein ligase E3B

0.385

RBGP1_HUMAN

Rab GTPase-activating protein 1

0.385

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.387

DHE3_HUMAN

Glutamate dehydrogenase 1, mitochondrial

0.387

RBSK_HUMAN

Ribokinase

0.388

IPO5_HUMAN

Importin-5

0.388

TRM7_HUMAN

Putative tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase

0.389

ODP2_HUMAN

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

0.389

PHB_HUMAN

Prohibitin

0.389

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.389

COX10_HUMAN

Protoheme IX farnesyltransferase, mitochondrial

0.389

EFGM_HUMAN

Elongation factor G, mitochondrial

0.390

MECR_HUMAN

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

0.390

ACAP2_HUMAN

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

0.391

COQ9_HUMAN

Ubiquinone biosynthesis protein COQ9, mitochondrial

0.391

HIBCH_HUMAN

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

0.391

MPPB_HUMAN

Mitochondrial-processing peptidase subunit beta

0.391

SDHA_HUMAN

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

0.392

AFG32_HUMAN

AFG3-like protein 2

0.392

JMJD6_HUMAN

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

0.393

RPR1B_HUMAN

Regulation of nuclear pre-mRNA domain-containing protein 1B

0.393

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.394

COX15_HUMAN

Cytochrome c oxidase assembly protein COX15 homolog

0.394

DLDH_HUMAN

Dihydrolipoyl dehydrogenase, mitochondrial

0.395

SCO1_HUMAN

Protein SCO1 homolog, mitochondrial

0.397

RPOM_HUMAN

DNA-directed RNA polymerase, mitochondrial

0.397

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.398

CBS_HUMAN

Cystathionine beta-synthase

0.398

CH60_HUMAN

60 kDa heat shock protein, mitochondrial

0.398

MPI_HUMAN

Mannose-6-phosphate isomerase

0.398

ZN622_HUMAN

Zinc finger protein 622

0.398

CISY_HUMAN

Citrate synthase, mitochondrial

0.398

DUS12_HUMAN

Dual specificity protein phosphatase 12

0.398

RT09_HUMAN

28S ribosomal protein S9, mitochondrial

0.399

PUM3_HUMAN

Pumilio homolog 3

0.399

LIAS_HUMAN

Lipoyl synthase, mitochondrial

0.399

ATPG_HUMAN

ATP synthase subunit gamma, mitochondrial

0.399

LYPA1_HUMAN

Acyl-protein thioesterase 1

0.399

MOGS_HUMAN

Mannosyl-oligosaccharide glucosidase

0.399

GUAA_HUMAN

GMP synthase [glutamine-hydrolyzing]

0.400

PSD13_HUMAN

26S proteasome non-ATPase regulatory subunit 13

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 133 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy