DTL_HUMAN 2019

Gene Name DTL

Description Denticleless protein homolog

Length 730

9606

Sequence

>sp|Q9NZJ0|DTL_HUMAN Denticleless protein homolog
MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPINRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQAEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENKNWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQEDFCGPEHSTEL

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.323

ACLY_HUMAN

ATP-citrate synthase

0.349

RBM39_HUMAN

RNA-binding protein 39

0.353

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.355

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.356

CSN3_HUMAN

COP9 signalosome complex subunit 3

0.362

GPTC1_HUMAN

G patch domain-containing protein 1

0.362

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.367

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.368

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.368

TPC10_HUMAN

Trafficking protein particle complex subunit 10

0.369

SYF2_HUMAN

Pre-mRNA-splicing factor SYF2

0.369

PIMT_HUMAN

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

0.371

DNJC3_HUMAN

DnaJ homolog subfamily C member 3

0.374

ACSF2_HUMAN

Acyl-CoA synthetase family member 2, mitochondrial

0.374

CSN7A_HUMAN

COP9 signalosome complex subunit 7a

0.375

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.376

KDM8_HUMAN

Bifunctional peptidase and arginyl-hydroxylase JMJD5

0.376

CTBL1_HUMAN

Beta-catenin-like protein 1

0.376

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.377

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.379

THOC1_HUMAN

THO complex subunit 1

0.379

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.379

AT2A2_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

0.380

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.380

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.383

RBM8A_HUMAN

RNA-binding protein 8A

0.383

TIM_HUMAN

Protein timeless homolog

0.383

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.384

AGO4_HUMAN

Protein argonaute-4

0.385

AGO3_HUMAN

Protein argonaute-3

0.385

NSRP1_HUMAN

Nuclear speckle splicing regulatory protein 1

0.386

GALM_HUMAN

Aldose 1-epimerase

0.386

CD11B_HUMAN

Cyclin-dependent kinase 11B

0.386

RAD1_HUMAN

Cell cycle checkpoint protein RAD1

0.388

DDB1_HUMAN

DNA damage-binding protein 1

0.388

TFP11_HUMAN

Tuftelin-interacting protein 11

0.389

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.389

CHRD1_HUMAN

Cysteine and histidine-rich domain-containing protein 1

0.389

NDUV2_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

0.390

AGO2_HUMAN

Protein argonaute-2

0.391

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.391

FAN1_HUMAN

Fanconi-associated nuclease 1

0.391

CPSF2_HUMAN

Cleavage and polyadenylation specificity factor subunit 2

0.391

LACB2_HUMAN

Endoribonuclease LACTB2

0.392

PPIL1_HUMAN

Peptidyl-prolyl cis-trans isomerase-like 1

0.392

RANB9_HUMAN

Ran-binding protein 9

0.392

EIF3L_HUMAN

Eukaryotic translation initiation factor 3 subunit L

0.392

C19L2_HUMAN

CWF19-like protein 2

0.392

AGO1_HUMAN

Protein argonaute-1

0.393

NIPA2_HUMAN

Magnesium transporter NIPA2

0.393

SC16A_HUMAN

Protein transport protein Sec16A

0.393

NDUV1_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.393

VTA1_HUMAN

Vacuolar protein sorting-associated protein VTA1 homolog

0.394

CATIN_HUMAN

Cactin

0.394

RAD9A_HUMAN

Cell cycle checkpoint control protein RAD9A

0.394

ECD_HUMAN

Protein ecdysoneless homolog

0.394

NUDC_HUMAN

Nuclear migration protein nudC

0.395

COPE_HUMAN

Coatomer subunit epsilon

0.395

CD11A_HUMAN

Cyclin-dependent kinase 11A

0.396

UVRAG_HUMAN

UV radiation resistance-associated gene protein

0.396

STRAP_HUMAN

Serine-threonine kinase receptor-associated protein

0.397

CC130_HUMAN

Coiled-coil domain-containing protein 130

0.397

RBM25_HUMAN

RNA-binding protein 25

0.397

SCPDL_HUMAN

Saccharopine dehydrogenase-like oxidoreductase

0.397

RL28_HUMAN

60S ribosomal protein L28

0.398

G3BP2_HUMAN

Ras GTPase-activating protein-binding protein 2

0.398

CLPT1_HUMAN

Cleft lip and palate transmembrane protein 1

0.398

ARL8B_HUMAN

ADP-ribosylation factor-like protein 8B

0.398

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.399

EXOC1_HUMAN

Exocyst complex component 1

0.399

MAK_HUMAN

Serine/threonine-protein kinase MAK

0.400

MCCB_HUMAN

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

0.400

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 114 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy