PPR3C_HUMAN 2019

Gene Name PPR3C

Description Protein phosphatase 1 regulatory subunit 3C

Length 317

9606

Sequence

>sp|Q9UQK1|PPR3C_HUMAN Protein phosphatase 1 regulatory subunit 3C
MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PPR3B_HUMAN

Protein phosphatase 1 regulatory subunit 3B

0.263

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PPR3B_HUMAN

Protein phosphatase 1 regulatory subunit 3B

0.266

GOLP3_HUMAN

Golgi phosphoprotein 3

0.329

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.330

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.337

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.338

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.340

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.347

SURF4_HUMAN

Surfeit locus protein 4

0.348

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.348

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.350

DPP4_HUMAN

Dipeptidyl peptidase 4

0.352

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.352

VIGLN_HUMAN

Vigilin

0.352

GDE_HUMAN

Glycogen debranching enzyme

0.354

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.355

SEPR_HUMAN

Prolyl endopeptidase FAP

0.360

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.366

S39A9_HUMAN

Zinc transporter ZIP9

0.368

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.369

PB1_HUMAN

Protein polybromo-1

0.370

ZNT1_HUMAN

Zinc transporter 1

0.372

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.372

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.373

PBDC1_HUMAN

Protein PBDC1

0.374

CACP_HUMAN

Carnitine O-acetyltransferase

0.375

CEGT_HUMAN

Ceramide glucosyltransferase

0.376

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.376

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.376

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.377

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.377

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.377

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.378

SEPT7_HUMAN

Septin-7

0.378

HIP1_HUMAN

Huntingtin-interacting protein 1

0.378

RHOA_HUMAN

Transforming protein RhoA

0.380

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.381

SOS1_HUMAN

Son of sevenless homolog 1

0.382

DYR_HUMAN

Dihydrofolate reductase

0.382

MOT12_HUMAN

Monocarboxylate transporter 12

0.382

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.382

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.382

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.383

CUL1_HUMAN

Cullin-1

0.384

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.386

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.386

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.389

SOS2_HUMAN

Son of sevenless homolog 2

0.389

SRF_HUMAN

Serum response factor

0.390

GATA4_HUMAN

Transcription factor GATA-4

0.390

SNX12_HUMAN

Sorting nexin-12

0.391

NPRL2_HUMAN

GATOR complex protein NPRL2

0.392

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.393

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.393

STRP1_HUMAN

Striatin-interacting protein 1

0.393

S2536_HUMAN

Solute carrier family 25 member 36

0.393

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.395

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.395

M3K4_HUMAN

Mitogen-activated protein kinase kinase kinase 4

0.397

YLAT2_HUMAN

Y+L amino acid transporter 2

0.397

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.398

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 82 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy