NOSIP_HUMAN 2019

Gene Name NOSIP

Description Nitric oxide synthase-interacting protein

Length 301

9606

Sequence

>sp|Q9Y314|NOSIP_HUMAN Nitric oxide synthase-interacting protein
MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CD11B_HUMAN

Cyclin-dependent kinase 11B

0.346

FA50A_HUMAN

Protein FAM50A

0.346

SNR40_HUMAN

U5 small nuclear ribonucleoprotein 40 kDa protein

0.349

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.354

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.356

CLK2_HUMAN

Dual specificity protein kinase CLK2

0.360

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.360

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.361

KDM5C_HUMAN

Lysine-specific demethylase 5C

0.362

CD11A_HUMAN

Cyclin-dependent kinase 11A

0.366

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.368

CTBL1_HUMAN

Beta-catenin-like protein 1

0.368

RBM8A_HUMAN

RNA-binding protein 8A

0.370

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.370

C19L2_HUMAN

CWF19-like protein 2

0.371

WDR83_HUMAN

WD repeat domain-containing protein 83

0.371

RANB9_HUMAN

Ran-binding protein 9

0.371

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.372

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.373

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.374

ADT2_HUMAN

ADP/ATP translocase 2

0.374

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.374

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.375

VPS52_HUMAN

Vacuolar protein sorting-associated protein 52 homolog

0.375

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.377

TI17B_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-B

0.378

KDM5B_HUMAN

Lysine-specific demethylase 5B

0.378

SNW1_HUMAN

SNW domain-containing protein 1

0.379

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.380

EMC3_HUMAN

ER membrane protein complex subunit 3

0.380

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.380

STX6_HUMAN

Syntaxin-6

0.381

CATD_HUMAN

Cathepsin D

0.383

HTSF1_HUMAN

HIV Tat-specific factor 1

0.384

CYB5_HUMAN

Cytochrome b5

0.384

SNAA_HUMAN

Alpha-soluble NSF attachment protein

0.385

SR140_HUMAN

U2 snRNP-associated SURP motif-containing protein

0.386

RAB6A_HUMAN

Ras-related protein Rab-6A

0.386

MFAP1_HUMAN

Microfibrillar-associated protein 1

0.387

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.387

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.387

UBE2N_HUMAN

Ubiquitin-conjugating enzyme E2 N

0.388

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.388

RPOM_HUMAN

DNA-directed RNA polymerase, mitochondrial

0.388

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.388

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.388

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.388

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.388

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.389

THOC1_HUMAN

THO complex subunit 1

0.390

SPF45_HUMAN

Splicing factor 45

0.390

RBM25_HUMAN

RNA-binding protein 25

0.391

THOC3_HUMAN

THO complex subunit 3

0.391

ORC2_HUMAN

Origin recognition complex subunit 2

0.392

P4R3B_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3B

0.392

SNAB_HUMAN

Beta-soluble NSF attachment protein

0.392

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.392

RBM42_HUMAN

RNA-binding protein 42

0.393

SPT6H_HUMAN

Transcription elongation factor SPT6

0.393

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.393

SPF27_HUMAN

Pre-mRNA-splicing factor SPF27

0.394

CWC15_HUMAN

Spliceosome-associated protein CWC15 homolog

0.394

S14L2_HUMAN

SEC14-like protein 2

0.394

STX16_HUMAN

Syntaxin-16

0.395

IWS1_HUMAN

Protein IWS1 homolog

0.396

SNUT1_HUMAN

U4/U6.U5 tri-snRNP-associated protein 1

0.397

SF3B6_HUMAN

Splicing factor 3B subunit 6

0.397

SF3A1_HUMAN

Splicing factor 3A subunit 1

0.397

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.397

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.398

TIM10_HUMAN

Mitochondrial import inner membrane translocase subunit Tim10

0.398

VAC14_HUMAN

Protein VAC14 homolog

0.399

U2AF2_HUMAN

Splicing factor U2AF 65 kDa subunit

0.399

RBM22_HUMAN

Pre-mRNA-splicing factor RBM22

0.399

CRNL1_HUMAN

Crooked neck-like protein 1

0.399

BIG2_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 2

0.399

EMC4_HUMAN

ER membrane protein complex subunit 4

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RBM8A_HUMAN

RNA-binding protein 8A

0.358

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.364

CD11B_HUMAN

Cyclin-dependent kinase 11B

0.370

RBM39_HUMAN

RNA-binding protein 39

0.373

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.374

CTBL1_HUMAN

Beta-catenin-like protein 1

0.375

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.377

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.379

KDM8_HUMAN

Bifunctional peptidase and arginyl-hydroxylase JMJD5

0.381

ACLY_HUMAN

ATP-citrate synthase

0.381

AT2A2_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

0.381

PPIL1_HUMAN

Peptidyl-prolyl cis-trans isomerase-like 1

0.381

EIF3L_HUMAN

Eukaryotic translation initiation factor 3 subunit L

0.382

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.383

CD11A_HUMAN

Cyclin-dependent kinase 11A

0.383

AT2A1_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

0.383

PIMT_HUMAN

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

0.384

ODBA_HUMAN

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

0.384

CC130_HUMAN

Coiled-coil domain-containing protein 130

0.384

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.387

WDR83_HUMAN

WD repeat domain-containing protein 83

0.387

GCDH_HUMAN

Glutaryl-CoA dehydrogenase, mitochondrial

0.387

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.387

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.387

MFAP1_HUMAN

Microfibrillar-associated protein 1

0.387

C19L2_HUMAN

CWF19-like protein 2

0.388

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.389

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.390

CLPT1_HUMAN

Cleft lip and palate transmembrane protein 1

0.391

NUDC_HUMAN

Nuclear migration protein nudC

0.393

RANB9_HUMAN

Ran-binding protein 9

0.393

FA50A_HUMAN

Protein FAM50A

0.394

GPTC1_HUMAN

G patch domain-containing protein 1

0.396

SNR40_HUMAN

U5 small nuclear ribonucleoprotein 40 kDa protein

0.398

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.399

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.400

WDR70_HUMAN

WD repeat-containing protein 70

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 131 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy