TPRKB_HUMAN 2019

Gene Name TPRKB

Description EKC/KEOPS complex subunit TPRKB

Length 175

9606

Sequence

>sp|Q9Y3C4|TPRKB_HUMAN EKC/KEOPS complex subunit TPRKB
MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

GUAA_HUMAN

GMP synthase [glutamine-hydrolyzing]

0.380

PIGT_HUMAN

GPI transamidase component PIG-T

0.381

PSME4_HUMAN

Proteasome activator complex subunit 4

0.382

UMPS_HUMAN

Uridine 5-monophosphate synthase

0.384

F262_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

0.384

F263_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

0.384

PUR9_HUMAN

Bifunctional purine biosynthesis protein PURH

0.385

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.385

GCH1_HUMAN

GTP cyclohydrolase 1

0.385

COG3_HUMAN

Conserved oligomeric Golgi complex subunit 3

0.385

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.386

CBS_HUMAN

Cystathionine beta-synthase

0.386

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.387

DDX3X_HUMAN

ATP-dependent RNA helicase DDX3X

0.387

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.387

NIPBL_HUMAN

Nipped-B-like protein

0.387

TAZ_HUMAN

Tafazzin

0.389

GOSR1_HUMAN

Golgi SNAP receptor complex member 1

0.389

CGL_HUMAN

Cystathionine gamma-lyase

0.389

FUMH_HUMAN

Fumarate hydratase, mitochondrial

0.389

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.390

LIAS_HUMAN

Lipoyl synthase, mitochondrial

0.390

SDHA_HUMAN

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

0.390

TKFC_HUMAN

Triokinase/FMN cyclase

0.390

SNW1_HUMAN

SNW domain-containing protein 1

0.390

F264_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

0.391

GATA_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.391

MDHM_HUMAN

Malate dehydrogenase, mitochondrial

0.392

ALG1_HUMAN

Chitobiosyldiphosphodolichol beta-mannosyltransferase

0.392

PPME1_HUMAN

Protein phosphatase methylesterase 1

0.392

CISY_HUMAN

Citrate synthase, mitochondrial

0.392

XPP3_HUMAN

Xaa-Pro aminopeptidase 3

0.392

PAQR2_HUMAN

Adiponectin receptor protein 2

0.392

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.392

TIPRL_HUMAN

TIP41-like protein

0.392

BCAT1_HUMAN

Branched-chain-amino-acid aminotransferase, cytosolic

0.392

BECN1_HUMAN

Beclin-1

0.392

MPPB_HUMAN

Mitochondrial-processing peptidase subunit beta

0.393

UBE2N_HUMAN

Ubiquitin-conjugating enzyme E2 N

0.393

PCF11_HUMAN

Pre-mRNA cleavage complex 2 protein Pcf11

0.393

ATPG_HUMAN

ATP synthase subunit gamma, mitochondrial

0.393

TNPO3_HUMAN

Transportin-3

0.393

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.393

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.393

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.393

HDDC2_HUMAN

HD domain-containing protein 2

0.393

AFG32_HUMAN

AFG3-like protein 2

0.393

PUR2_HUMAN

Trifunctional purine biosynthetic protein adenosine-3

0.393

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.393

NAA30_HUMAN

N-alpha-acetyltransferase 30

0.393

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.393

SNF5_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

0.393

DPOA2_HUMAN

DNA polymerase alpha subunit B

0.394

DLDH_HUMAN

Dihydrolipoyl dehydrogenase, mitochondrial

0.394

TALDO_HUMAN

Transaldolase

0.394

MIPEP_HUMAN

Mitochondrial intermediate peptidase

0.394

EXOC5_HUMAN

Exocyst complex component 5

0.394

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.394

ADHX_HUMAN

Alcohol dehydrogenase class-3

0.394

SSU72_HUMAN

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

0.395

SYYM_HUMAN

Tyrosine--tRNA ligase, mitochondrial

0.395

ARI1_HUMAN

E3 ubiquitin-protein ligase ARIH1

0.395

ATP7A_HUMAN

Copper-transporting ATPase 1

0.395

BCS1_HUMAN

Mitochondrial chaperone BCS1

0.395

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.395

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.395

HIBCH_HUMAN

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

0.395

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.395

ADCK1_HUMAN

Uncharacterized aarF domain-containing protein kinase 1

0.395

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.396

SYDM_HUMAN

Aspartate--tRNA ligase, mitochondrial

0.396

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.396

PGM1_HUMAN

Phosphoglucomutase-1

0.396

ANM8_HUMAN

Protein arginine N-methyltransferase 8

0.396

LONM_HUMAN

Lon protease homolog, mitochondrial

0.396

KCC1A_HUMAN

Calcium/calmodulin-dependent protein kinase type 1

0.396

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.396

SUV3_HUMAN

ATP-dependent RNA helicase SUPV3L1, mitochondrial

0.396

RRP12_HUMAN

RRP12-like protein

0.396

PI3R4_HUMAN

Phosphoinositide 3-kinase regulatory subunit 4

0.396

SURF1_HUMAN

Surfeit locus protein 1

0.396

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.396

PIGS_HUMAN

GPI transamidase component PIG-S

0.396

DCOR_HUMAN

Ornithine decarboxylase

0.397

ALG2_HUMAN

Alpha-1,3/1,6-mannosyltransferase ALG2

0.397

PURA2_HUMAN

Adenylosuccinate synthetase isozyme 2

0.397

MPI_HUMAN

Mannose-6-phosphate isomerase

0.397

CH60_HUMAN

60 kDa heat shock protein, mitochondrial

0.397

NOL6_HUMAN

Nucleolar protein 6

0.397

EBP2_HUMAN

Probable rRNA-processing protein EBP2

0.397

TBCE_HUMAN

Tubulin-specific chaperone E

0.397

STK24_HUMAN

Serine/threonine-protein kinase 24

0.397

OST48_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

0.397

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.397

ZN622_HUMAN

Zinc finger protein 622

0.397

UBR2_HUMAN

E3 ubiquitin-protein ligase UBR2

0.397

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.397

NFU1_HUMAN

NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

0.397

ASNA_HUMAN

ATPase ASNA1

0.397

DBR1_HUMAN

Lariat debranching enzyme

0.397

SRR_HUMAN

Serine racemase

0.397

CSTF3_HUMAN

Cleavage stimulation factor subunit 3

0.398

PCID2_HUMAN

PCI domain-containing protein 2

0.398

FMO5_HUMAN

Dimethylaniline monooxygenase [N-oxide-forming] 5

0.398

MOGT2_HUMAN

2-acylglycerol O-acyltransferase 2

0.398

AAKG2_HUMAN

5-AMP-activated protein kinase subunit gamma-2

0.398

EIF3G_HUMAN

Eukaryotic translation initiation factor 3 subunit G

0.398

SUCA_HUMAN

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

0.398

ALG3_HUMAN

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

0.398

PHB_HUMAN

Prohibitin

0.398

VPS8_HUMAN

Vacuolar protein sorting-associated protein 8 homolog

0.398

RT05_HUMAN

28S ribosomal protein S5, mitochondrial

0.398

SIN3A_HUMAN

Paired amphipathic helix protein Sin3a

0.398

FXL20_HUMAN

F-box/LRR-repeat protein 20

0.398

THIL_HUMAN

Acetyl-CoA acetyltransferase, mitochondrial

0.398

NOC3L_HUMAN

Nucleolar complex protein 3 homolog

0.398

PLAP_HUMAN

Phospholipase A-2-activating protein

0.399

PSD13_HUMAN

26S proteasome non-ATPase regulatory subunit 13

0.399

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.399

APC1_HUMAN

Anaphase-promoting complex subunit 1

0.399

EMC1_HUMAN

ER membrane protein complex subunit 1

0.399

VDAC1_HUMAN

Voltage-dependent anion-selective channel protein 1

0.399

EFGM_HUMAN

Elongation factor G, mitochondrial

0.399

VTI1A_HUMAN

Vesicle transport through interaction with t-SNAREs homolog 1A

0.399

OTU6B_HUMAN

Deubiquitinase OTUD6B

0.399

SNF8_HUMAN

Vacuolar-sorting protein SNF8

0.399

ODO2_HUMAN

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

0.399

CNO6L_HUMAN

CCR4-NOT transcription complex subunit 6-like

0.399

PDS5B_HUMAN

Sister chromatid cohesion protein PDS5 homolog B

0.399

CDC16_HUMAN

Cell division cycle protein 16 homolog

0.399

CRNL1_HUMAN

Crooked neck-like protein 1

0.399

MON1A_HUMAN

Vacuolar fusion protein MON1 homolog A

0.399

TIM44_HUMAN

Mitochondrial import inner membrane translocase subunit TIM44

0.399

F261_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

0.400

PUR8_HUMAN

Adenylosuccinate lyase

0.400

COQ8A_HUMAN

Atypical kinase COQ8A, mitochondrial

0.400

IDH3A_HUMAN

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

0.400

PIGU_HUMAN

Phosphatidylinositol glycan anchor biosynthesis class U protein

0.400

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.400

CATD_HUMAN

Cathepsin D

0.400

ACACA_HUMAN

Acetyl-CoA carboxylase 1

0.400

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.400

TOP1_HUMAN

DNA topoisomerase 1

0.400

NOP14_HUMAN

Nucleolar protein 14

0.400

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.400

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.400

SETD2_HUMAN

Histone-lysine N-methyltransferase SETD2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 117 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy