NDC80_HUMAN 2019

Gene Name NDC80

Description Kinetochore protein NDC80 homolog

Length 642

9606

Sequence

>sp|O14777|NDC80_HUMAN Kinetochore protein NDC80 homolog
MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPHIVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.334

IWS1_HUMAN

Protein IWS1 homolog

0.352

CSTF3_HUMAN

Cleavage stimulation factor subunit 3

0.362

CTDP1_HUMAN

RNA polymerase II subunit A C-terminal domain phosphatase

0.369

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.369

UFD1_HUMAN

Ubiquitin recognition factor in ER-associated degradation protein 1

0.379

AAPK2_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-2

0.379

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.379

RAE1L_HUMAN

mRNA export factor

0.382

CNO6L_HUMAN

CCR4-NOT transcription complex subunit 6-like

0.384

DERL2_HUMAN

Derlin-2

0.386

SIN3A_HUMAN

Paired amphipathic helix protein Sin3a

0.386

RBBP6_HUMAN

E3 ubiquitin-protein ligase RBBP6

0.386

TIM10_HUMAN

Mitochondrial import inner membrane translocase subunit Tim10

0.387

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.387

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.387

VATH_HUMAN

V-type proton ATPase subunit H

0.387

PABP4_HUMAN

Polyadenylate-binding protein 4

0.387

HSF1_HUMAN

Heat shock factor protein 1

0.388

SP16H_HUMAN

FACT complex subunit SPT16

0.389

ZC3HF_HUMAN

Zinc finger CCCH domain-containing protein 15

0.389

SENP1_HUMAN

Sentrin-specific protease 1

0.390

SSRP1_HUMAN

FACT complex subunit SSRP1

0.390

WDR33_HUMAN

pre-mRNA 3 end processing protein WDR33

0.390

CNOT4_HUMAN

CCR4-NOT transcription complex subunit 4

0.391

TAF7_HUMAN

Transcription initiation factor TFIID subunit 7

0.392

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.392

ALR_HUMAN

FAD-linked sulfhydryl oxidase ALR

0.392

BRX1_HUMAN

Ribosome biogenesis protein BRX1 homolog

0.393

RAN_HUMAN

GTP-binding nuclear protein Ran

0.393

KAT2B_HUMAN

Histone acetyltransferase KAT2B

0.393

SCYL1_HUMAN

N-terminal kinase-like protein

0.393

COPA_HUMAN

Coatomer subunit alpha

0.394

CDC5L_HUMAN

Cell division cycle 5-like protein

0.394

PSMD3_HUMAN

26S proteasome non-ATPase regulatory subunit 3

0.394

CNOT7_HUMAN

CCR4-NOT transcription complex subunit 7

0.394

PTPA_HUMAN

Serine/threonine-protein phosphatase 2A activator

0.394

RBM19_HUMAN

Probable RNA-binding protein 19

0.394

PSMD7_HUMAN

26S proteasome non-ATPase regulatory subunit 7

0.394

ASF1A_HUMAN

Histone chaperone ASF1A

0.394

SMC6_HUMAN

Structural maintenance of chromosomes protein 6

0.395

VIP1_HUMAN

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

0.395

MAT1_HUMAN

CDK-activating kinase assembly factor MAT1

0.395

CPSF1_HUMAN

Cleavage and polyadenylation specificity factor subunit 1

0.395

RBBP4_HUMAN

Histone-binding protein RBBP4

0.395

RL6_HUMAN

60S ribosomal protein L6

0.395

CNOT9_HUMAN

CCR4-NOT transcription complex subunit 9

0.395

COPD_HUMAN

Coatomer subunit delta

0.395

SCFD1_HUMAN

Sec1 family domain-containing protein 1

0.395

SMRD1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

0.396

DPOA2_HUMAN

DNA polymerase alpha subunit B

0.396

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.396

LPIN1_HUMAN

Phosphatidate phosphatase LPIN1

0.397

LPIN2_HUMAN

Phosphatidate phosphatase LPIN2

0.397

YETS4_HUMAN

YEATS domain-containing protein 4

0.397

UBE2H_HUMAN

Ubiquitin-conjugating enzyme E2 H

0.397

CLK2_HUMAN

Dual specificity protein kinase CLK2

0.397

S35C2_HUMAN

Solute carrier family 35 member C2

0.397

OTU6B_HUMAN

Deubiquitinase OTUD6B

0.397

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.399

ING5_HUMAN

Inhibitor of growth protein 5

0.399

GANP_HUMAN

Germinal-center associated nuclear protein

0.399

XPR1_HUMAN

Xenotropic and polytropic retrovirus receptor 1

0.399

CND1_HUMAN

Condensin complex subunit 1

0.399

NFYB_HUMAN

Nuclear transcription factor Y subunit beta

0.399

STX16_HUMAN

Syntaxin-16

0.399

MCE1_HUMAN

mRNA-capping enzyme

0.399

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.400

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.400

MAEA_HUMAN

E3 ubiquitin-protein transferase MAEA

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.334

IWS1_HUMAN

Protein IWS1 homolog

0.352

CSTF3_HUMAN

Cleavage stimulation factor subunit 3

0.362

CTDP1_HUMAN

RNA polymerase II subunit A C-terminal domain phosphatase

0.369

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.369

UFD1_HUMAN

Ubiquitin recognition factor in ER-associated degradation protein 1

0.379

AAPK2_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-2

0.379

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.379

RAE1L_HUMAN

mRNA export factor

0.382

CNO6L_HUMAN

CCR4-NOT transcription complex subunit 6-like

0.384

DERL2_HUMAN

Derlin-2

0.386

SIN3A_HUMAN

Paired amphipathic helix protein Sin3a

0.386

RBBP6_HUMAN

E3 ubiquitin-protein ligase RBBP6

0.386

TIM10_HUMAN

Mitochondrial import inner membrane translocase subunit Tim10

0.387

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.387

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.387

VATH_HUMAN

V-type proton ATPase subunit H

0.387

PABP4_HUMAN

Polyadenylate-binding protein 4

0.387

HSF1_HUMAN

Heat shock factor protein 1

0.388

SP16H_HUMAN

FACT complex subunit SPT16

0.389

ZC3HF_HUMAN

Zinc finger CCCH domain-containing protein 15

0.389

SENP1_HUMAN

Sentrin-specific protease 1

0.390

SSRP1_HUMAN

FACT complex subunit SSRP1

0.390

WDR33_HUMAN

pre-mRNA 3 end processing protein WDR33

0.390

CNOT4_HUMAN

CCR4-NOT transcription complex subunit 4

0.391

TAF7_HUMAN

Transcription initiation factor TFIID subunit 7

0.392

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.392

ALR_HUMAN

FAD-linked sulfhydryl oxidase ALR

0.392

BRX1_HUMAN

Ribosome biogenesis protein BRX1 homolog

0.393

RAN_HUMAN

GTP-binding nuclear protein Ran

0.393

KAT2B_HUMAN

Histone acetyltransferase KAT2B

0.393

SCYL1_HUMAN

N-terminal kinase-like protein

0.393

COPA_HUMAN

Coatomer subunit alpha

0.394

CDC5L_HUMAN

Cell division cycle 5-like protein

0.394

PSMD3_HUMAN

26S proteasome non-ATPase regulatory subunit 3

0.394

CNOT7_HUMAN

CCR4-NOT transcription complex subunit 7

0.394

PTPA_HUMAN

Serine/threonine-protein phosphatase 2A activator

0.394

RBM19_HUMAN

Probable RNA-binding protein 19

0.394

PSMD7_HUMAN

26S proteasome non-ATPase regulatory subunit 7

0.394

ASF1A_HUMAN

Histone chaperone ASF1A

0.394

SMC6_HUMAN

Structural maintenance of chromosomes protein 6

0.395

VIP1_HUMAN

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

0.395

MAT1_HUMAN

CDK-activating kinase assembly factor MAT1

0.395

CPSF1_HUMAN

Cleavage and polyadenylation specificity factor subunit 1

0.395

RBBP4_HUMAN

Histone-binding protein RBBP4

0.395

RL6_HUMAN

60S ribosomal protein L6

0.395

CNOT9_HUMAN

CCR4-NOT transcription complex subunit 9

0.395

COPD_HUMAN

Coatomer subunit delta

0.395

SCFD1_HUMAN

Sec1 family domain-containing protein 1

0.395

SMRD1_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

0.396

DPOA2_HUMAN

DNA polymerase alpha subunit B

0.396

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.396

LPIN1_HUMAN

Phosphatidate phosphatase LPIN1

0.397

LPIN2_HUMAN

Phosphatidate phosphatase LPIN2

0.397

YETS4_HUMAN

YEATS domain-containing protein 4

0.397

UBE2H_HUMAN

Ubiquitin-conjugating enzyme E2 H

0.397

CLK2_HUMAN

Dual specificity protein kinase CLK2

0.397

S35C2_HUMAN

Solute carrier family 35 member C2

0.397

OTU6B_HUMAN

Deubiquitinase OTUD6B

0.397

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.399

ING5_HUMAN

Inhibitor of growth protein 5

0.399

GANP_HUMAN

Germinal-center associated nuclear protein

0.399

XPR1_HUMAN

Xenotropic and polytropic retrovirus receptor 1

0.399

CND1_HUMAN

Condensin complex subunit 1

0.399

NFYB_HUMAN

Nuclear transcription factor Y subunit beta

0.399

STX16_HUMAN

Syntaxin-16

0.399

MCE1_HUMAN

mRNA-capping enzyme

0.399

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.400

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.400

MAEA_HUMAN

E3 ubiquitin-protein transferase MAEA

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 137 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy