LCAT_HUMAN 2019

Gene Name LCAT

Description Phosphatidylcholine-sterol acyltransferase

Length 440

9606

Sequence

>sp|P04180|LCAT_HUMAN Phosphatidylcholine-sterol acyltransferase
MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PAG15_HUMAN

Group XV phospholipase A2

0.168

YETS4_HUMAN

YEATS domain-containing protein 4

0.373

SNW1_HUMAN

SNW domain-containing protein 1

0.376

FNTA_HUMAN

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

0.376

EMC3_HUMAN

ER membrane protein complex subunit 3

0.377

AMPD2_HUMAN

AMP deaminase 2

0.377

COPB2_HUMAN

Coatomer subunit beta

0.378

SEC13_HUMAN

Protein SEC13 homolog

0.379

SPCS3_HUMAN

Signal peptidase complex subunit 3

0.379

CRNL1_HUMAN

Crooked neck-like protein 1

0.380

EIF3B_HUMAN

Eukaryotic translation initiation factor 3 subunit B

0.380

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.382

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.382

XPO2_HUMAN

Exportin-2

0.382

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.384

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.384

RAN_HUMAN

GTP-binding nuclear protein Ran

0.385

BRX1_HUMAN

Ribosome biogenesis protein BRX1 homolog

0.385

ISY1_HUMAN

Pre-mRNA-splicing factor ISY1 homolog

0.385

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.385

ATG3_HUMAN

Ubiquitin-like-conjugating enzyme ATG3

0.385

CDC5L_HUMAN

Cell division cycle 5-like protein

0.386

PSMD3_HUMAN

26S proteasome non-ATPase regulatory subunit 3

0.386

RBM19_HUMAN

Probable RNA-binding protein 19

0.386

ARI1_HUMAN

E3 ubiquitin-protein ligase ARIH1

0.386

ATG7_HUMAN

Ubiquitin-like modifier-activating enzyme ATG7

0.386

VATC1_HUMAN

V-type proton ATPase subunit C 1

0.387

PLRG1_HUMAN

Pleiotropic regulator 1

0.389

CNOT1_HUMAN

CCR4-NOT transcription complex subunit 1

0.389

DBR1_HUMAN

Lariat debranching enzyme

0.389

A0A0B4J2E5_HUMAN

Uncharacterized protein

0.389

AP2S1_HUMAN

AP-2 complex subunit sigma

0.389

RAB5A_HUMAN

Ras-related protein Rab-5A

0.390

WDR1_HUMAN

WD repeat-containing protein 1

0.390

YIPF5_HUMAN

Protein YIPF5

0.391

VP33A_HUMAN

Vacuolar protein sorting-associated protein 33A

0.391

DERL2_HUMAN

Derlin-2

0.393

PSMD6_HUMAN

26S proteasome non-ATPase regulatory subunit 6

0.393

VA0D1_HUMAN

V-type proton ATPase subunit d 1

0.393

RPF2_HUMAN

Ribosome production factor 2 homolog

0.393

COPB_HUMAN

Coatomer subunit beta

0.393

TNPO3_HUMAN

Transportin-3

0.393

PUM1_HUMAN

Pumilio homolog 1

0.394

LSG1_HUMAN

Large subunit GTPase 1 homolog

0.394

PSMD1_HUMAN

26S proteasome non-ATPase regulatory subunit 1

0.394

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.394

VAC14_HUMAN

Protein VAC14 homolog

0.395

CHMP5_HUMAN

Charged multivesicular body protein 5

0.395

EMC2_HUMAN

ER membrane protein complex subunit 2

0.395

RACK1_HUMAN

Receptor of activated protein C kinase 1

0.395

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.395

TB22B_HUMAN

TBC1 domain family member 22B

0.397

BMS1_HUMAN

Ribosome biogenesis protein BMS1 homolog

0.397

BYST_HUMAN

Bystin

0.397

APC10_HUMAN

Anaphase-promoting complex subunit 10

0.397

PWP2_HUMAN

Periodic tryptophan protein 2 homolog

0.397

SSRP1_HUMAN

FACT complex subunit SSRP1

0.397

SENP1_HUMAN

Sentrin-specific protease 1

0.397

MTOR_HUMAN

Serine/threonine-protein kinase mTOR

0.398

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.398

BT3L4_HUMAN

Transcription factor BTF3 homolog 4

0.398

UBP13_HUMAN

Ubiquitin carboxyl-terminal hydrolase 13

0.398

YIF1B_HUMAN

Protein YIF1B

0.399

SYF1_HUMAN

Pre-mRNA-splicing factor SYF1

0.399

RU2A_HUMAN

U2 small nuclear ribonucleoprotein A

0.399

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PAG15_HUMAN

Group XV phospholipase A2

0.168

YETS4_HUMAN

YEATS domain-containing protein 4

0.373

SNW1_HUMAN

SNW domain-containing protein 1

0.376

FNTA_HUMAN

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

0.376

EMC3_HUMAN

ER membrane protein complex subunit 3

0.377

AMPD2_HUMAN

AMP deaminase 2

0.377

COPB2_HUMAN

Coatomer subunit beta

0.378

SEC13_HUMAN

Protein SEC13 homolog

0.379

SPCS3_HUMAN

Signal peptidase complex subunit 3

0.379

CRNL1_HUMAN

Crooked neck-like protein 1

0.380

EIF3B_HUMAN

Eukaryotic translation initiation factor 3 subunit B

0.380

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.382

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.382

XPO2_HUMAN

Exportin-2

0.382

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.384

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.384

RAN_HUMAN

GTP-binding nuclear protein Ran

0.385

BRX1_HUMAN

Ribosome biogenesis protein BRX1 homolog

0.385

ISY1_HUMAN

Pre-mRNA-splicing factor ISY1 homolog

0.385

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.385

ATG3_HUMAN

Ubiquitin-like-conjugating enzyme ATG3

0.385

CDC5L_HUMAN

Cell division cycle 5-like protein

0.386

PSMD3_HUMAN

26S proteasome non-ATPase regulatory subunit 3

0.386

RBM19_HUMAN

Probable RNA-binding protein 19

0.386

ARI1_HUMAN

E3 ubiquitin-protein ligase ARIH1

0.386

ATG7_HUMAN

Ubiquitin-like modifier-activating enzyme ATG7

0.386

VATC1_HUMAN

V-type proton ATPase subunit C 1

0.387

PLRG1_HUMAN

Pleiotropic regulator 1

0.389

CNOT1_HUMAN

CCR4-NOT transcription complex subunit 1

0.389

DBR1_HUMAN

Lariat debranching enzyme

0.389

A0A0B4J2E5_HUMAN

Uncharacterized protein

0.389

AP2S1_HUMAN

AP-2 complex subunit sigma

0.389

RAB5A_HUMAN

Ras-related protein Rab-5A

0.390

WDR1_HUMAN

WD repeat-containing protein 1

0.390

YIPF5_HUMAN

Protein YIPF5

0.391

VP33A_HUMAN

Vacuolar protein sorting-associated protein 33A

0.391

DERL2_HUMAN

Derlin-2

0.393

PSMD6_HUMAN

26S proteasome non-ATPase regulatory subunit 6

0.393

VA0D1_HUMAN

V-type proton ATPase subunit d 1

0.393

RPF2_HUMAN

Ribosome production factor 2 homolog

0.393

COPB_HUMAN

Coatomer subunit beta

0.393

TNPO3_HUMAN

Transportin-3

0.393

PUM1_HUMAN

Pumilio homolog 1

0.394

LSG1_HUMAN

Large subunit GTPase 1 homolog

0.394

PSMD1_HUMAN

26S proteasome non-ATPase regulatory subunit 1

0.394

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.394

VAC14_HUMAN

Protein VAC14 homolog

0.395

CHMP5_HUMAN

Charged multivesicular body protein 5

0.395

EMC2_HUMAN

ER membrane protein complex subunit 2

0.395

RACK1_HUMAN

Receptor of activated protein C kinase 1

0.395

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.395

TB22B_HUMAN

TBC1 domain family member 22B

0.397

BMS1_HUMAN

Ribosome biogenesis protein BMS1 homolog

0.397

BYST_HUMAN

Bystin

0.397

APC10_HUMAN

Anaphase-promoting complex subunit 10

0.397

PWP2_HUMAN

Periodic tryptophan protein 2 homolog

0.397

SSRP1_HUMAN

FACT complex subunit SSRP1

0.397

SENP1_HUMAN

Sentrin-specific protease 1

0.397

MTOR_HUMAN

Serine/threonine-protein kinase mTOR

0.398

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.398

BT3L4_HUMAN

Transcription factor BTF3 homolog 4

0.398

UBP13_HUMAN

Ubiquitin carboxyl-terminal hydrolase 13

0.398

YIF1B_HUMAN

Protein YIF1B

0.399

SYF1_HUMAN

Pre-mRNA-splicing factor SYF1

0.399

RU2A_HUMAN

U2 small nuclear ribonucleoprotein A

0.399

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 138 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy