RU17_HUMAN 2019

Gene Name RU17

Description U1 small nuclear ribonucleoprotein 70 kDa

Length 437

9606

Sequence

>sp|P08621|RU17_HUMAN U1 small nuclear ribonucleoprotein 70 kDa
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SYF1_HUMAN

Pre-mRNA-splicing factor SYF1

0.370

NAA16_HUMAN

N-alpha-acetyltransferase 16, NatA auxiliary subunit

0.372

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.377

PCID2_HUMAN

PCI domain-containing protein 2

0.377

PABP2_HUMAN

Polyadenylate-binding protein 2

0.377

SNW1_HUMAN

SNW domain-containing protein 1

0.378

STX16_HUMAN

Syntaxin-16

0.378

NTF2_HUMAN

Nuclear transport factor 2

0.379

RRP1B_HUMAN

Ribosomal RNA processing protein 1 homolog B

0.380

SNRPA_HUMAN

U1 small nuclear ribonucleoprotein A

0.380

CRNL1_HUMAN

Crooked neck-like protein 1

0.383

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.383

XPO2_HUMAN

Exportin-2

0.384

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.384

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.384

SNAA_HUMAN

Alpha-soluble NSF attachment protein

0.384

RAB6A_HUMAN

Ras-related protein Rab-6A

0.385

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.385

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.385

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.386

STX5_HUMAN

Syntaxin-5

0.386

SLU7_HUMAN

Pre-mRNA-splicing factor SLU7

0.388

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.388

ISY1_HUMAN

Pre-mRNA-splicing factor ISY1 homolog

0.388

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.389

PSA6_HUMAN

Proteasome subunit alpha type-6

0.390

CNOT9_HUMAN

CCR4-NOT transcription complex subunit 9

0.390

SF3A3_HUMAN

Splicing factor 3A subunit 3

0.390

DBR1_HUMAN

Lariat debranching enzyme

0.391

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.391

SNAB_HUMAN

Beta-soluble NSF attachment protein

0.391

PLRG1_HUMAN

Pleiotropic regulator 1

0.391

RAB7A_HUMAN

Ras-related protein Rab-7a

0.392

SPT6H_HUMAN

Transcription elongation factor SPT6

0.392

VP33A_HUMAN

Vacuolar protein sorting-associated protein 33A

0.393

EIFCL_HUMAN

Eukaryotic translation initiation factor 3 subunit C-like protein

0.393

RL22_HUMAN

60S ribosomal protein L22

0.393

EIF3C_HUMAN

Eukaryotic translation initiation factor 3 subunit C

0.393

ABT1_HUMAN

Activator of basal transcription 1

0.396

BIG1_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 1

0.397

BIG2_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 2

0.398

SP16H_HUMAN

FACT complex subunit SPT16

0.398

COPG2_HUMAN

Coatomer subunit gamma-2

0.398

EIF3B_HUMAN

Eukaryotic translation initiation factor 3 subunit B

0.398

SSF1_HUMAN

Suppressor of SWI4 1 homolog

0.399

H2B1C_HUMAN

Histone H2B type 1-C/E/F/G/I

0.399

RRP1_HUMAN

Ribosomal RNA processing protein 1 homolog A

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SYF1_HUMAN

Pre-mRNA-splicing factor SYF1

0.370

NAA16_HUMAN

N-alpha-acetyltransferase 16, NatA auxiliary subunit

0.372

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.377

PCID2_HUMAN

PCI domain-containing protein 2

0.377

PABP2_HUMAN

Polyadenylate-binding protein 2

0.377

SNW1_HUMAN

SNW domain-containing protein 1

0.378

STX16_HUMAN

Syntaxin-16

0.378

NTF2_HUMAN

Nuclear transport factor 2

0.379

RRP1B_HUMAN

Ribosomal RNA processing protein 1 homolog B

0.380

SNRPA_HUMAN

U1 small nuclear ribonucleoprotein A

0.380

CRNL1_HUMAN

Crooked neck-like protein 1

0.383

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.383

XPO2_HUMAN

Exportin-2

0.384

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.384

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.384

SNAA_HUMAN

Alpha-soluble NSF attachment protein

0.384

RAB6A_HUMAN

Ras-related protein Rab-6A

0.385

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.385

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.385

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.386

STX5_HUMAN

Syntaxin-5

0.386

SLU7_HUMAN

Pre-mRNA-splicing factor SLU7

0.388

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.388

ISY1_HUMAN

Pre-mRNA-splicing factor ISY1 homolog

0.388

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.389

PSA6_HUMAN

Proteasome subunit alpha type-6

0.390

CNOT9_HUMAN

CCR4-NOT transcription complex subunit 9

0.390

SF3A3_HUMAN

Splicing factor 3A subunit 3

0.390

DBR1_HUMAN

Lariat debranching enzyme

0.391

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.391

SNAB_HUMAN

Beta-soluble NSF attachment protein

0.391

PLRG1_HUMAN

Pleiotropic regulator 1

0.391

RAB7A_HUMAN

Ras-related protein Rab-7a

0.392

SPT6H_HUMAN

Transcription elongation factor SPT6

0.392

VP33A_HUMAN

Vacuolar protein sorting-associated protein 33A

0.393

EIFCL_HUMAN

Eukaryotic translation initiation factor 3 subunit C-like protein

0.393

RL22_HUMAN

60S ribosomal protein L22

0.393

EIF3C_HUMAN

Eukaryotic translation initiation factor 3 subunit C

0.393

ABT1_HUMAN

Activator of basal transcription 1

0.396

BIG1_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 1

0.397

BIG2_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 2

0.398

SP16H_HUMAN

FACT complex subunit SPT16

0.398

COPG2_HUMAN

Coatomer subunit gamma-2

0.398

EIF3B_HUMAN

Eukaryotic translation initiation factor 3 subunit B

0.398

SSF1_HUMAN

Suppressor of SWI4 1 homolog

0.399

H2B1C_HUMAN

Histone H2B type 1-C/E/F/G/I

0.399

RRP1_HUMAN

Ribosomal RNA processing protein 1 homolog A

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 134 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy