RFA2_HUMAN 2019

Gene Name RFA2

Description Replication protein A 32 kDa subunit

Length 270

9606

Sequence

>sp|P15927|RFA2_HUMAN Replication protein A 32 kDa subunit
MWNSGFESYGSSSYGGAGGYTQSPGGFGSPAPSQAEKKSRARAQHIVPCTISQLLSATLVDEVFRIGNVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAAPMDVRQWVDTDDTSSENTVVPPETYVKVAGHLRSFQNKKSLVAFKIMPLEDMNEFTTHILEVINAHMVLSKANSQPSAGRAPISNPGMSEAGNFGGNSFMPANGLTVAQNQVLNLIKACPRPEGLNFQDLKNQLKHMSVSSIKQAVDFLSNEGHIYSTVDDDHFKSTDAE

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.349

CPSF1_HUMAN

Cleavage and polyadenylation specificity factor subunit 1

0.372

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.372

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.373

STAG1_HUMAN

Cohesin subunit SA-1

0.373

RAB5A_HUMAN

Ras-related protein Rab-5A

0.376

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.379

SIN3A_HUMAN

Paired amphipathic helix protein Sin3a

0.379

RBBP6_HUMAN

E3 ubiquitin-protein ligase RBBP6

0.379

HSF1_HUMAN

Heat shock factor protein 1

0.380

HSF2_HUMAN

Heat shock factor protein 2

0.382

NU155_HUMAN

Nuclear pore complex protein Nup155

0.382

CDC16_HUMAN

Cell division cycle protein 16 homolog

0.382

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.382

WDR33_HUMAN

pre-mRNA 3 end processing protein WDR33

0.383

GLU2B_HUMAN

Glucosidase 2 subunit beta

0.383

MTOR_HUMAN

Serine/threonine-protein kinase mTOR

0.384

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.384

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.384

ELOC_HUMAN

Elongin-C

0.384

2ABB_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

0.386

NOC3L_HUMAN

Nucleolar complex protein 3 homolog

0.386

SGT1_HUMAN

Protein SGT1 homolog

0.386

NIPBL_HUMAN

Nipped-B-like protein

0.387

ATAD1_HUMAN

ATPase family AAA domain-containing protein 1

0.387

CDC5L_HUMAN

Cell division cycle 5-like protein

0.387

UFD1_HUMAN

Ubiquitin recognition factor in ER-associated degradation protein 1

0.387

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.388

PI3R4_HUMAN

Phosphoinositide 3-kinase regulatory subunit 4

0.388

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.388

CNOT9_HUMAN

CCR4-NOT transcription complex subunit 9

0.389

WDR1_HUMAN

WD repeat-containing protein 1

0.392

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.392

GANP_HUMAN

Germinal-center associated nuclear protein

0.392

IWS1_HUMAN

Protein IWS1 homolog

0.393

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.393

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.393

ST38L_HUMAN

Serine/threonine-protein kinase 38-like

0.393

STK38_HUMAN

Serine/threonine-protein kinase 38

0.393

DERL2_HUMAN

Derlin-2

0.394

PDS5B_HUMAN

Sister chromatid cohesion protein PDS5 homolog B

0.394

GOSR1_HUMAN

Golgi SNAP receptor complex member 1

0.394

MP2K2_HUMAN

Dual specificity mitogen-activated protein kinase kinase 2

0.394

PDS5A_HUMAN

Sister chromatid cohesion protein PDS5 homolog A

0.394

MP2K1_HUMAN

Dual specificity mitogen-activated protein kinase kinase 1

0.394

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.395

UTP20_HUMAN

Small subunit processome component 20 homolog

0.395

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.395

SEC13_HUMAN

Protein SEC13 homolog

0.395

ATG9A_HUMAN

Autophagy-related protein 9A

0.396

NOP14_HUMAN

Nucleolar protein 14

0.396

CAB39_HUMAN

Calcium-binding protein 39

0.396

CHMP5_HUMAN

Charged multivesicular body protein 5

0.396

UGGG2_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 2

0.396

VPS16_HUMAN

Vacuolar protein sorting-associated protein 16 homolog

0.396

CRNL1_HUMAN

Crooked neck-like protein 1

0.397

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.397

HSF4_HUMAN

Heat shock factor protein 4

0.397

SIN3B_HUMAN

Paired amphipathic helix protein Sin3b

0.397

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.397

APC10_HUMAN

Anaphase-promoting complex subunit 10

0.398

IF5_HUMAN

Eukaryotic translation initiation factor 5

0.398

IMB1_HUMAN

Importin subunit beta-1

0.398

DPOE1_HUMAN

DNA polymerase epsilon catalytic subunit A

0.398

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.398

WDR12_HUMAN

Ribosome biogenesis protein WDR12

0.399

WDHD1_HUMAN

WD repeat and HMG-box DNA-binding protein 1

0.399

STK26_HUMAN

Serine/threonine-protein kinase 26

0.399

UTP15_HUMAN

U3 small nucleolar RNA-associated protein 15 homolog

0.399

NUP98_HUMAN

Nuclear pore complex protein Nup98-Nup96

0.399

SERC1_HUMAN

Serine incorporator 1

0.400

STAG2_HUMAN

Cohesin subunit SA-2

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.349

CPSF1_HUMAN

Cleavage and polyadenylation specificity factor subunit 1

0.372

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.372

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.373

STAG1_HUMAN

Cohesin subunit SA-1

0.373

RAB5A_HUMAN

Ras-related protein Rab-5A

0.376

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.379

SIN3A_HUMAN

Paired amphipathic helix protein Sin3a

0.379

RBBP6_HUMAN

E3 ubiquitin-protein ligase RBBP6

0.379

HSF1_HUMAN

Heat shock factor protein 1

0.380

HSF2_HUMAN

Heat shock factor protein 2

0.382

NU155_HUMAN

Nuclear pore complex protein Nup155

0.382

CDC16_HUMAN

Cell division cycle protein 16 homolog

0.382

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.382

WDR33_HUMAN

pre-mRNA 3 end processing protein WDR33

0.383

GLU2B_HUMAN

Glucosidase 2 subunit beta

0.383

MTOR_HUMAN

Serine/threonine-protein kinase mTOR

0.384

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.384

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.384

ELOC_HUMAN

Elongin-C

0.384

2ABB_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

0.386

NOC3L_HUMAN

Nucleolar complex protein 3 homolog

0.386

SGT1_HUMAN

Protein SGT1 homolog

0.386

NIPBL_HUMAN

Nipped-B-like protein

0.387

ATAD1_HUMAN

ATPase family AAA domain-containing protein 1

0.387

CDC5L_HUMAN

Cell division cycle 5-like protein

0.387

UFD1_HUMAN

Ubiquitin recognition factor in ER-associated degradation protein 1

0.387

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.388

PI3R4_HUMAN

Phosphoinositide 3-kinase regulatory subunit 4

0.388

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.388

CNOT9_HUMAN

CCR4-NOT transcription complex subunit 9

0.389

WDR1_HUMAN

WD repeat-containing protein 1

0.392

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.392

GANP_HUMAN

Germinal-center associated nuclear protein

0.392

IWS1_HUMAN

Protein IWS1 homolog

0.393

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.393

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.393

ST38L_HUMAN

Serine/threonine-protein kinase 38-like

0.393

STK38_HUMAN

Serine/threonine-protein kinase 38

0.393

DERL2_HUMAN

Derlin-2

0.394

PDS5B_HUMAN

Sister chromatid cohesion protein PDS5 homolog B

0.394

GOSR1_HUMAN

Golgi SNAP receptor complex member 1

0.394

MP2K2_HUMAN

Dual specificity mitogen-activated protein kinase kinase 2

0.394

PDS5A_HUMAN

Sister chromatid cohesion protein PDS5 homolog A

0.394

MP2K1_HUMAN

Dual specificity mitogen-activated protein kinase kinase 1

0.394

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.395

UTP20_HUMAN

Small subunit processome component 20 homolog

0.395

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.395

SEC13_HUMAN

Protein SEC13 homolog

0.395

ATG9A_HUMAN

Autophagy-related protein 9A

0.396

NOP14_HUMAN

Nucleolar protein 14

0.396

CAB39_HUMAN

Calcium-binding protein 39

0.396

CHMP5_HUMAN

Charged multivesicular body protein 5

0.396

UGGG2_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 2

0.396

VPS16_HUMAN

Vacuolar protein sorting-associated protein 16 homolog

0.396

CRNL1_HUMAN

Crooked neck-like protein 1

0.397

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.397

HSF4_HUMAN

Heat shock factor protein 4

0.397

SIN3B_HUMAN

Paired amphipathic helix protein Sin3b

0.397

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.397

APC10_HUMAN

Anaphase-promoting complex subunit 10

0.398

IF5_HUMAN

Eukaryotic translation initiation factor 5

0.398

IMB1_HUMAN

Importin subunit beta-1

0.398

DPOE1_HUMAN

DNA polymerase epsilon catalytic subunit A

0.398

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.398

WDR12_HUMAN

Ribosome biogenesis protein WDR12

0.399

WDHD1_HUMAN

WD repeat and HMG-box DNA-binding protein 1

0.399

STK26_HUMAN

Serine/threonine-protein kinase 26

0.399

UTP15_HUMAN

U3 small nucleolar RNA-associated protein 15 homolog

0.399

NUP98_HUMAN

Nuclear pore complex protein Nup98-Nup96

0.399

SERC1_HUMAN

Serine incorporator 1

0.400

STAG2_HUMAN

Cohesin subunit SA-2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 136 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy