DNJC3_HUMAN 2019

Gene Name DNJC3

Description DnaJ homolog subfamily C member 3

Length 504

9606

Sequence

>sp|Q13217|DNJC3_HUMAN DnaJ homolog subfamily C member 3
MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.351

RAD21_HUMAN

Double-strand-break repair protein rad21 homolog

0.357

WDR1_HUMAN

WD repeat-containing protein 1

0.361

UTP20_HUMAN

Small subunit processome component 20 homolog

0.365

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.370

DDB1_HUMAN

DNA damage-binding protein 1

0.374

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.374

STAG1_HUMAN

Cohesin subunit SA-1

0.375

AP3D1_HUMAN

AP-3 complex subunit delta-1

0.379

CHRD1_HUMAN

Cysteine and histidine-rich domain-containing protein 1

0.379

VPS51_HUMAN

Vacuolar protein sorting-associated protein 51 homolog

0.381

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.382

UGGG2_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 2

0.383

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.384

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.384

MTMR2_HUMAN

Myotubularin-related protein 2

0.386

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.386

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.386

SERC1_HUMAN

Serine incorporator 1

0.387

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.387

STAG2_HUMAN

Cohesin subunit SA-2

0.387

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.387

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.388

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.388

EXOC1_HUMAN

Exocyst complex component 1

0.389

ARPC2_HUMAN

Actin-related protein 2/3 complex subunit 2

0.390

NIPBL_HUMAN

Nipped-B-like protein

0.390

PI3R4_HUMAN

Phosphoinositide 3-kinase regulatory subunit 4

0.390

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.392

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.394

MTMR6_HUMAN

Myotubularin-related protein 6

0.396

ARP3_HUMAN

Actin-related protein 3

0.396

EMC3_HUMAN

ER membrane protein complex subunit 3

0.396

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.396

ALG3_HUMAN

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

0.397

MP2K2_HUMAN

Dual specificity mitogen-activated protein kinase kinase 2

0.397

ARPC4_HUMAN

Actin-related protein 2/3 complex subunit 4

0.397

GOSR1_HUMAN

Golgi SNAP receptor complex member 1

0.397

MP2K1_HUMAN

Dual specificity mitogen-activated protein kinase kinase 1

0.397

STX6_HUMAN

Syntaxin-6

0.397

MFRN2_HUMAN

Mitoferrin-2

0.397

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.397

ATG9A_HUMAN

Autophagy-related protein 9A

0.398

VAC14_HUMAN

Protein VAC14 homolog

0.399

CAB39_HUMAN

Calcium-binding protein 39

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.351

RAD21_HUMAN

Double-strand-break repair protein rad21 homolog

0.357

WDR1_HUMAN

WD repeat-containing protein 1

0.361

UTP20_HUMAN

Small subunit processome component 20 homolog

0.365

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.370

DDB1_HUMAN

DNA damage-binding protein 1

0.374

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.374

STAG1_HUMAN

Cohesin subunit SA-1

0.375

AP3D1_HUMAN

AP-3 complex subunit delta-1

0.379

CHRD1_HUMAN

Cysteine and histidine-rich domain-containing protein 1

0.379

VPS51_HUMAN

Vacuolar protein sorting-associated protein 51 homolog

0.381

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.382

UGGG2_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 2

0.383

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.384

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.384

MTMR2_HUMAN

Myotubularin-related protein 2

0.386

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.386

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.386

SERC1_HUMAN

Serine incorporator 1

0.387

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.387

STAG2_HUMAN

Cohesin subunit SA-2

0.387

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.387

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.388

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.388

EXOC1_HUMAN

Exocyst complex component 1

0.389

ARPC2_HUMAN

Actin-related protein 2/3 complex subunit 2

0.390

NIPBL_HUMAN

Nipped-B-like protein

0.390

PI3R4_HUMAN

Phosphoinositide 3-kinase regulatory subunit 4

0.390

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.392

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.394

MTMR6_HUMAN

Myotubularin-related protein 6

0.396

ARP3_HUMAN

Actin-related protein 3

0.396

EMC3_HUMAN

ER membrane protein complex subunit 3

0.396

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.396

ALG3_HUMAN

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

0.397

MP2K2_HUMAN

Dual specificity mitogen-activated protein kinase kinase 2

0.397

ARPC4_HUMAN

Actin-related protein 2/3 complex subunit 4

0.397

GOSR1_HUMAN

Golgi SNAP receptor complex member 1

0.397

MP2K1_HUMAN

Dual specificity mitogen-activated protein kinase kinase 1

0.397

STX6_HUMAN

Syntaxin-6

0.397

MFRN2_HUMAN

Mitoferrin-2

0.397

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.397

ATG9A_HUMAN

Autophagy-related protein 9A

0.398

VAC14_HUMAN

Protein VAC14 homolog

0.399

CAB39_HUMAN

Calcium-binding protein 39

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 132 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy