UGPA_HUMAN 2019

Gene Name UGPA

Description UTP--glucose-1-phosphate uridylyltransferase

Length 508

9606

Sequence

>sp|Q16851|UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLLPVAKDVSYSGENTEAWYPPGHGDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGATVDLYILNHLMNPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

2ABB_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

0.359

SEC13_HUMAN

Protein SEC13 homolog

0.369

BRX1_HUMAN

Ribosome biogenesis protein BRX1 homolog

0.375

RAN_HUMAN

GTP-binding nuclear protein Ran

0.375

EIF3I_HUMAN

Eukaryotic translation initiation factor 3 subunit I

0.376

RAE1L_HUMAN

mRNA export factor

0.378

FIP1_HUMAN

Pre-mRNA 3-end-processing factor FIP1

0.379

CCNB1_HUMAN

G2/mitotic-specific cyclin-B1

0.381

PSMD6_HUMAN

26S proteasome non-ATPase regulatory subunit 6

0.382

COPB_HUMAN

Coatomer subunit beta

0.382

RPF2_HUMAN

Ribosome production factor 2 homolog

0.382

DERL2_HUMAN

Derlin-2

0.382

VA0D1_HUMAN

V-type proton ATPase subunit d 1

0.382

COPB2_HUMAN

Coatomer subunit beta

0.382

PUM1_HUMAN

Pumilio homolog 1

0.383

ERD22_HUMAN

ER lumen protein-retaining receptor 2

0.383

2ABA_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

0.384

2ABG_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

0.384

APC10_HUMAN

Anaphase-promoting complex subunit 10

0.386

PSMD7_HUMAN

26S proteasome non-ATPase regulatory subunit 7

0.390

RBM19_HUMAN

Probable RNA-binding protein 19

0.390

CDC5L_HUMAN

Cell division cycle 5-like protein

0.390

AAPK2_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-2

0.390

CNOT7_HUMAN

CCR4-NOT transcription complex subunit 7

0.390

PSMD3_HUMAN

26S proteasome non-ATPase regulatory subunit 3

0.390

PTPA_HUMAN

Serine/threonine-protein phosphatase 2A activator

0.390

COPA_HUMAN

Coatomer subunit alpha

0.390

PRP8_HUMAN

Pre-mRNA-processing-splicing factor 8

0.390

SC23A_HUMAN

Protein transport protein Sec23A

0.390

NSF_HUMAN

Vesicle-fusing ATPase

0.390

DCA13_HUMAN

DDB1- and CUL4-associated factor 13

0.390

ASF1A_HUMAN

Histone chaperone ASF1A

0.390

UBP5_HUMAN

Ubiquitin carboxyl-terminal hydrolase 5

0.390

SC23B_HUMAN

Protein transport protein Sec23B

0.390

UFD1_HUMAN

Ubiquitin recognition factor in ER-associated degradation protein 1

0.390

CPSF1_HUMAN

Cleavage and polyadenylation specificity factor subunit 1

0.390

RAD21_HUMAN

Double-strand-break repair protein rad21 homolog

0.390

CSK2B_HUMAN

Casein kinase II subunit beta

0.391

PUM2_HUMAN

Pumilio homolog 2

0.391

MCES_HUMAN

mRNA cap guanine-N7 methyltransferase

0.391

2ABD_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

0.392

AURKA_HUMAN

Aurora kinase A

0.392

NMD3_HUMAN

60S ribosomal export protein NMD3

0.395

STK38_HUMAN

Serine/threonine-protein kinase 38

0.396

ST38L_HUMAN

Serine/threonine-protein kinase 38-like

0.396

TCPZ_HUMAN

T-complex protein 1 subunit zeta

0.396

AAPK1_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-1

0.396

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.397

PABP1_HUMAN

Polyadenylate-binding protein 1

0.397

DNM1L_HUMAN

Dynamin-1-like protein

0.397

PSMD2_HUMAN

26S proteasome non-ATPase regulatory subunit 2

0.397

PABP4_HUMAN

Polyadenylate-binding protein 4

0.397

VATH_HUMAN

V-type proton ATPase subunit H

0.397

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.397

PSD11_HUMAN

26S proteasome non-ATPase regulatory subunit 11

0.397

CSK21_HUMAN

Casein kinase II subunit alpha

0.397

XPO1_HUMAN

Exportin-1

0.397

GPN3_HUMAN

GPN-loop GTPase 3

0.399

SPTC1_HUMAN

Serine palmitoyltransferase 1

0.399

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.399

SENP1_HUMAN

Sentrin-specific protease 1

0.400

WDR33_HUMAN

pre-mRNA 3 end processing protein WDR33

0.400

IF5_HUMAN

Eukaryotic translation initiation factor 5

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

2ABB_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

0.359

SEC13_HUMAN

Protein SEC13 homolog

0.369

BRX1_HUMAN

Ribosome biogenesis protein BRX1 homolog

0.375

RAN_HUMAN

GTP-binding nuclear protein Ran

0.375

EIF3I_HUMAN

Eukaryotic translation initiation factor 3 subunit I

0.376

RAE1L_HUMAN

mRNA export factor

0.378

FIP1_HUMAN

Pre-mRNA 3-end-processing factor FIP1

0.379

CCNB1_HUMAN

G2/mitotic-specific cyclin-B1

0.381

PSMD6_HUMAN

26S proteasome non-ATPase regulatory subunit 6

0.382

COPB_HUMAN

Coatomer subunit beta

0.382

RPF2_HUMAN

Ribosome production factor 2 homolog

0.382

DERL2_HUMAN

Derlin-2

0.382

VA0D1_HUMAN

V-type proton ATPase subunit d 1

0.382

COPB2_HUMAN

Coatomer subunit beta

0.382

PUM1_HUMAN

Pumilio homolog 1

0.383

ERD22_HUMAN

ER lumen protein-retaining receptor 2

0.383

2ABA_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

0.384

2ABG_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

0.384

APC10_HUMAN

Anaphase-promoting complex subunit 10

0.386

PSMD7_HUMAN

26S proteasome non-ATPase regulatory subunit 7

0.390

RBM19_HUMAN

Probable RNA-binding protein 19

0.390

CDC5L_HUMAN

Cell division cycle 5-like protein

0.390

AAPK2_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-2

0.390

CNOT7_HUMAN

CCR4-NOT transcription complex subunit 7

0.390

PSMD3_HUMAN

26S proteasome non-ATPase regulatory subunit 3

0.390

PTPA_HUMAN

Serine/threonine-protein phosphatase 2A activator

0.390

COPA_HUMAN

Coatomer subunit alpha

0.390

PRP8_HUMAN

Pre-mRNA-processing-splicing factor 8

0.390

SC23A_HUMAN

Protein transport protein Sec23A

0.390

NSF_HUMAN

Vesicle-fusing ATPase

0.390

DCA13_HUMAN

DDB1- and CUL4-associated factor 13

0.390

ASF1A_HUMAN

Histone chaperone ASF1A

0.390

UBP5_HUMAN

Ubiquitin carboxyl-terminal hydrolase 5

0.390

SC23B_HUMAN

Protein transport protein Sec23B

0.390

UFD1_HUMAN

Ubiquitin recognition factor in ER-associated degradation protein 1

0.390

CPSF1_HUMAN

Cleavage and polyadenylation specificity factor subunit 1

0.390

RAD21_HUMAN

Double-strand-break repair protein rad21 homolog

0.390

CSK2B_HUMAN

Casein kinase II subunit beta

0.391

PUM2_HUMAN

Pumilio homolog 2

0.391

MCES_HUMAN

mRNA cap guanine-N7 methyltransferase

0.391

2ABD_HUMAN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

0.392

AURKA_HUMAN

Aurora kinase A

0.392

NMD3_HUMAN

60S ribosomal export protein NMD3

0.395

STK38_HUMAN

Serine/threonine-protein kinase 38

0.396

ST38L_HUMAN

Serine/threonine-protein kinase 38-like

0.396

TCPZ_HUMAN

T-complex protein 1 subunit zeta

0.396

AAPK1_HUMAN

5-AMP-activated protein kinase catalytic subunit alpha-1

0.396

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.397

PABP1_HUMAN

Polyadenylate-binding protein 1

0.397

DNM1L_HUMAN

Dynamin-1-like protein

0.397

PSMD2_HUMAN

26S proteasome non-ATPase regulatory subunit 2

0.397

PABP4_HUMAN

Polyadenylate-binding protein 4

0.397

VATH_HUMAN

V-type proton ATPase subunit H

0.397

PSD12_HUMAN

26S proteasome non-ATPase regulatory subunit 12

0.397

PSD11_HUMAN

26S proteasome non-ATPase regulatory subunit 11

0.397

CSK21_HUMAN

Casein kinase II subunit alpha

0.397

XPO1_HUMAN

Exportin-1

0.397

GPN3_HUMAN

GPN-loop GTPase 3

0.399

SPTC1_HUMAN

Serine palmitoyltransferase 1

0.399

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.399

SENP1_HUMAN

Sentrin-specific protease 1

0.400

WDR33_HUMAN

pre-mRNA 3 end processing protein WDR33

0.400

IF5_HUMAN

Eukaryotic translation initiation factor 5

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 156 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy