DPS1_HUMAN 2019

Gene Name DPS1

Description Decaprenyl-diphosphate synthase subunit 1

Length 415

9606

Sequence

>sp|Q5T2R2|DPS1_HUMAN Decaprenyl-diphosphate synthase subunit 1
MASRWWRWRRGCSWKPAARSPGPGSPGRAGPLGPSAAAEVRAQVHRRKGLDLSQIPYINLVKHLTSACPNVCRISRFHHTTPDSKTHSGEKYTDPFKLGWRDLKGLYEDIRKELLISTSELKEMSEYYFDGKGKAFRPIIVALMARACNIHHNNSRHVQASQRAIALIAEMIHTASLVHDDVIDDASSRRGKHTVNKIWGEKKAVLAGDLILSAASIALARIGNTTVISILTQVIEDLVRGEFLQLGSKENENERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQMGKPTSADLKLGLATGPVLFACQQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYCHEAIREISKLRPSPERDALIQLSEIVLTRDK

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DHDDS_HUMAN

Dehydrodolichyl diphosphate synthase complex subunit DHDDS

0.288

PGK1_HUMAN

Phosphoglycerate kinase 1

0.296

PRPS1_HUMAN

Ribose-phosphate pyrophosphokinase 1

0.307

GFPT1_HUMAN

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

0.307

GUAA_HUMAN

GMP synthase [glutamine-hydrolyzing]

0.309

SYAC_HUMAN

Alanine--tRNA ligase, cytoplasmic

0.309

SRP54_HUMAN

Signal recognition particle 54 kDa protein

0.314

PURA1_HUMAN

Adenylosuccinate synthetase isozyme 1

0.314

PYRG1_HUMAN

CTP synthase 1

0.315

NTH_HUMAN

Endonuclease III-like protein 1

0.315

SYTC_HUMAN

Threonine--tRNA ligase, cytoplasmic

0.317

ENOA_HUMAN

Alpha-enolase

0.318

RL23_HUMAN

60S ribosomal protein L23

0.321

ENOB_HUMAN

Beta-enolase

0.322

PURA2_HUMAN

Adenylosuccinate synthetase isozyme 2

0.323

GLYM_HUMAN

Serine hydroxymethyltransferase, mitochondrial

0.324

GFPT2_HUMAN

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

0.325

OLA1_HUMAN

Obg-like ATPase 1

0.325

NFS1_HUMAN

Cysteine desulfurase, mitochondrial

0.326

ENOG_HUMAN

Gamma-enolase

0.326

RM11_HUMAN

39S ribosomal protein L11, mitochondrial

0.327

RPB2_HUMAN

DNA-directed RNA polymerase II subunit RPB2

0.329

RS15_HUMAN

40S ribosomal protein S15

0.330

SYVC_HUMAN

Valine--tRNA ligase

0.330

TOP3A_HUMAN

DNA topoisomerase 3-alpha

0.331

ITPA_HUMAN

Inosine triphosphate pyrophosphatase

0.331

PRPS2_HUMAN

Ribose-phosphate pyrophosphokinase 2

0.333

GLYC_HUMAN

Serine hydroxymethyltransferase, cytosolic

0.337

IDH3A_HUMAN

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

0.338

PYRG2_HUMAN

CTP synthase 2

0.340

GRP75_HUMAN

Stress-70 protein, mitochondrial

0.341

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.341

KAT3_HUMAN

Kynurenine--oxoglutarate transaminase 3

0.341

SYTC2_HUMAN

Threonine--tRNA ligase 2, cytoplasmic

0.342

DLDH_HUMAN

Dihydrolipoyl dehydrogenase, mitochondrial

0.343

PGK2_HUMAN

Phosphoglycerate kinase 2

0.343

CBS_HUMAN

Cystathionine beta-synthase

0.344

OAT_HUMAN

Ornithine aminotransferase, mitochondrial

0.354

IMDH2_HUMAN

Inosine-5-monophosphate dehydrogenase 2

0.354

COQ5_HUMAN

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

0.355

DNJA3_HUMAN

DnaJ homolog subfamily A member 3, mitochondrial

0.356

PUR8_HUMAN

Adenylosuccinate lyase

0.356

YRDC_HUMAN

YrdC domain-containing protein, mitochondrial

0.356

IMDH1_HUMAN

Inosine-5-monophosphate dehydrogenase 1

0.358

SDHA_HUMAN

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

0.358

RIR1_HUMAN

Ribonucleoside-diphosphate reductase large subunit

0.364

TOP2B_HUMAN

DNA topoisomerase 2-beta

0.364

RL11_HUMAN

60S ribosomal protein L11

0.365

PYR1_HUMAN

CAD protein

0.365

UMPS_HUMAN

Uridine 5-monophosphate synthase

0.365

ATP7A_HUMAN

Copper-transporting ATPase 1

0.366

ABCBA_HUMAN

ATP-binding cassette sub-family B member 10, mitochondrial

0.367

ATP7B_HUMAN

Copper-transporting ATPase 2

0.367

COAC_HUMAN

Phosphopantothenoylcysteine decarboxylase

0.368

KAT1_HUMAN

Kynurenine--oxoglutarate transaminase 1

0.369

GMPPB_HUMAN

Mannose-1-phosphate guanyltransferase beta

0.371

GATA_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.372

PRPS3_HUMAN

Ribose-phosphate pyrophosphokinase 3

0.373

RPB1_HUMAN

DNA-directed RNA polymerase II subunit RPB1

0.374

TOP2A_HUMAN

DNA topoisomerase 2-alpha

0.375

NADK_HUMAN

NAD kinase

0.375

RPC2_HUMAN

DNA-directed RNA polymerase III subunit RPC2

0.376

CH60_HUMAN

60 kDa heat shock protein, mitochondrial

0.379

FOLC_HUMAN

Folylpolyglutamate synthase, mitochondrial

0.379

PUR2_HUMAN

Trifunctional purine biosynthetic protein adenosine-3

0.382

GATB_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

0.383

TKT_HUMAN

Transketolase

0.387

DPM1_HUMAN

Dolichol-phosphate mannosyltransferase subunit 1

0.390

NDKB_HUMAN

Nucleoside diphosphate kinase B

0.390

PIGA_HUMAN

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

0.392

G3P_HUMAN

Glyceraldehyde-3-phosphate dehydrogenase

0.392

ABCA3_HUMAN

ATP-binding cassette sub-family A member 3

0.394

KPYM_HUMAN

Pyruvate kinase PKM

0.394

IMPA1_HUMAN

Inositol monophosphatase 1

0.397

EFTU_HUMAN

Elongation factor Tu, mitochondrial

0.398

SERA_HUMAN

D-3-phosphoglycerate dehydrogenase

0.399

RFC1_HUMAN

Replication factor C subunit 1

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DHDDS_HUMAN

Dehydrodolichyl diphosphate synthase complex subunit DHDDS

0.288

PGK1_HUMAN

Phosphoglycerate kinase 1

0.296

PRPS1_HUMAN

Ribose-phosphate pyrophosphokinase 1

0.307

GFPT1_HUMAN

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

0.307

GUAA_HUMAN

GMP synthase [glutamine-hydrolyzing]

0.309

SYAC_HUMAN

Alanine--tRNA ligase, cytoplasmic

0.309

SRP54_HUMAN

Signal recognition particle 54 kDa protein

0.314

PURA1_HUMAN

Adenylosuccinate synthetase isozyme 1

0.314

PYRG1_HUMAN

CTP synthase 1

0.315

NTH_HUMAN

Endonuclease III-like protein 1

0.315

SYTC_HUMAN

Threonine--tRNA ligase, cytoplasmic

0.317

ENOA_HUMAN

Alpha-enolase

0.318

RL23_HUMAN

60S ribosomal protein L23

0.321

ENOB_HUMAN

Beta-enolase

0.322

PURA2_HUMAN

Adenylosuccinate synthetase isozyme 2

0.323

GLYM_HUMAN

Serine hydroxymethyltransferase, mitochondrial

0.324

GFPT2_HUMAN

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

0.325

OLA1_HUMAN

Obg-like ATPase 1

0.325

NFS1_HUMAN

Cysteine desulfurase, mitochondrial

0.326

ENOG_HUMAN

Gamma-enolase

0.326

RM11_HUMAN

39S ribosomal protein L11, mitochondrial

0.327

RPB2_HUMAN

DNA-directed RNA polymerase II subunit RPB2

0.329

RS15_HUMAN

40S ribosomal protein S15

0.330

SYVC_HUMAN

Valine--tRNA ligase

0.330

TOP3A_HUMAN

DNA topoisomerase 3-alpha

0.331

ITPA_HUMAN

Inosine triphosphate pyrophosphatase

0.331

PRPS2_HUMAN

Ribose-phosphate pyrophosphokinase 2

0.333

GLYC_HUMAN

Serine hydroxymethyltransferase, cytosolic

0.337

IDH3A_HUMAN

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

0.338

PYRG2_HUMAN

CTP synthase 2

0.340

GRP75_HUMAN

Stress-70 protein, mitochondrial

0.341

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.341

KAT3_HUMAN

Kynurenine--oxoglutarate transaminase 3

0.341

SYTC2_HUMAN

Threonine--tRNA ligase 2, cytoplasmic

0.342

DLDH_HUMAN

Dihydrolipoyl dehydrogenase, mitochondrial

0.343

PGK2_HUMAN

Phosphoglycerate kinase 2

0.343

CBS_HUMAN

Cystathionine beta-synthase

0.344

OAT_HUMAN

Ornithine aminotransferase, mitochondrial

0.354

IMDH2_HUMAN

Inosine-5-monophosphate dehydrogenase 2

0.354

COQ5_HUMAN

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

0.355

DNJA3_HUMAN

DnaJ homolog subfamily A member 3, mitochondrial

0.356

PUR8_HUMAN

Adenylosuccinate lyase

0.356

YRDC_HUMAN

YrdC domain-containing protein, mitochondrial

0.356

IMDH1_HUMAN

Inosine-5-monophosphate dehydrogenase 1

0.358

SDHA_HUMAN

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

0.358

RIR1_HUMAN

Ribonucleoside-diphosphate reductase large subunit

0.364

TOP2B_HUMAN

DNA topoisomerase 2-beta

0.364

RL11_HUMAN

60S ribosomal protein L11

0.365

PYR1_HUMAN

CAD protein

0.365

UMPS_HUMAN

Uridine 5-monophosphate synthase

0.365

ATP7A_HUMAN

Copper-transporting ATPase 1

0.366

ABCBA_HUMAN

ATP-binding cassette sub-family B member 10, mitochondrial

0.367

ATP7B_HUMAN

Copper-transporting ATPase 2

0.367

COAC_HUMAN

Phosphopantothenoylcysteine decarboxylase

0.368

KAT1_HUMAN

Kynurenine--oxoglutarate transaminase 1

0.369

GMPPB_HUMAN

Mannose-1-phosphate guanyltransferase beta

0.371

GATA_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.372

PRPS3_HUMAN

Ribose-phosphate pyrophosphokinase 3

0.373

RPB1_HUMAN

DNA-directed RNA polymerase II subunit RPB1

0.374

TOP2A_HUMAN

DNA topoisomerase 2-alpha

0.375

NADK_HUMAN

NAD kinase

0.375

RPC2_HUMAN

DNA-directed RNA polymerase III subunit RPC2

0.376

CH60_HUMAN

60 kDa heat shock protein, mitochondrial

0.379

FOLC_HUMAN

Folylpolyglutamate synthase, mitochondrial

0.379

PUR2_HUMAN

Trifunctional purine biosynthetic protein adenosine-3

0.382

GATB_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

0.383

TKT_HUMAN

Transketolase

0.387

DPM1_HUMAN

Dolichol-phosphate mannosyltransferase subunit 1

0.390

NDKB_HUMAN

Nucleoside diphosphate kinase B

0.390

PIGA_HUMAN

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

0.392

G3P_HUMAN

Glyceraldehyde-3-phosphate dehydrogenase

0.392

ABCA3_HUMAN

ATP-binding cassette sub-family A member 3

0.394

KPYM_HUMAN

Pyruvate kinase PKM

0.394

IMPA1_HUMAN

Inositol monophosphatase 1

0.397

EFTU_HUMAN

Elongation factor Tu, mitochondrial

0.398

SERA_HUMAN

D-3-phosphoglycerate dehydrogenase

0.399

RFC1_HUMAN

Replication factor C subunit 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 335 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy