DEGS2_HUMAN 2019

Gene Name DEGS2

Description Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2

Length 323

9606

Sequence

>sp|Q6QHC5|DEGS2_HUMAN Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
MGNSASRSDFEWVYTDQPHTQRRKEILAKYPAIKALMRPDPRLKWAVLVLVLVQMLACWLVRGLAWRWLLFWAYAFGGCVNHSLTLAIHDISHNAAFGTGRAARNRWLAVFANLPVGVPYAASFKKYHVDHHRYLGGDGLDVDVPTRLEGWFFCTPARKLLWLVLQPFFYSLRPLCVHPKAVTRMEVLNTLVQLAADLAIFALWGLKPVVYLLASSFLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHVEHHDFPSIPGYNLPLVRKIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYARVKRVYRLAKDGL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DEGS1_HUMAN

Sphingolipid delta(4)-desaturase DES1

0.086

S36A1_HUMAN

Proton-coupled amino acid transporter 1

0.340

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.366

SAMC_HUMAN

S-adenosylmethionine mitochondrial carrier protein

0.369

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.369

S36A2_HUMAN

Proton-coupled amino acid transporter 2

0.370

XRCC6_HUMAN

X-ray repair cross-complementing protein 6

0.375

TBCB_HUMAN

Tubulin-folding cofactor B

0.375

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.375

ANC2_HUMAN

Anaphase-promoting complex subunit 2

0.377

ERO1A_HUMAN

ERO1-like protein alpha

0.379

ERO1B_HUMAN

ERO1-like protein beta

0.379

CUL3_HUMAN

Cullin-3

0.379

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.379

MFRN2_HUMAN

Mitoferrin-2

0.380

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.380

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.380

MFRN1_HUMAN

Mitoferrin-1

0.382

VPS16_HUMAN

Vacuolar protein sorting-associated protein 16 homolog

0.382

EBP2_HUMAN

Probable rRNA-processing protein EBP2

0.382

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.383

CYB5_HUMAN

Cytochrome b5

0.383

WDHD1_HUMAN

WD repeat and HMG-box DNA-binding protein 1

0.384

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.384

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.385

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.386

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.386

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.386

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.386

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.386

PA2G4_HUMAN

Proliferation-associated protein 2G4

0.386

RPOM_HUMAN

DNA-directed RNA polymerase, mitochondrial

0.386

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.386

VTA1_HUMAN

Vacuolar protein sorting-associated protein VTA1 homolog

0.387

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.388

UCHL3_HUMAN

Ubiquitin carboxyl-terminal hydrolase isozyme L3

0.388

MPC1_HUMAN

Mitochondrial pyruvate carrier 1

0.388

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.388

TMEDA_HUMAN

Transmembrane emp24 domain-containing protein 10

0.389

BRAP_HUMAN

BRCA1-associated protein

0.390

STAG1_HUMAN

Cohesin subunit SA-1

0.390

VPS39_HUMAN

Vam6/Vps39-like protein

0.392

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.393

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.393

TBCD_HUMAN

Tubulin-specific chaperone D

0.393

TIPRL_HUMAN

TIP41-like protein

0.394

AP3D1_HUMAN

AP-3 complex subunit delta-1

0.394

S36A4_HUMAN

Proton-coupled amino acid transporter 4

0.394

AMPD2_HUMAN

AMP deaminase 2

0.395

EMC3_HUMAN

ER membrane protein complex subunit 3

0.395

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.395

ALG8_HUMAN

Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

0.396

NOC4L_HUMAN

Nucleolar complex protein 4 homolog

0.396

EMC2_HUMAN

ER membrane protein complex subunit 2

0.397

VAC14_HUMAN

Protein VAC14 homolog

0.397

ALG12_HUMAN

Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

0.398

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.399

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.400

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.400

VPS54_HUMAN

Vacuolar protein sorting-associated protein 54

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DEGS1_HUMAN

Sphingolipid delta(4)-desaturase DES1

0.086

S36A1_HUMAN

Proton-coupled amino acid transporter 1

0.340

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.366

SAMC_HUMAN

S-adenosylmethionine mitochondrial carrier protein

0.369

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.369

S36A2_HUMAN

Proton-coupled amino acid transporter 2

0.370

XRCC6_HUMAN

X-ray repair cross-complementing protein 6

0.375

TBCB_HUMAN

Tubulin-folding cofactor B

0.375

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.375

ANC2_HUMAN

Anaphase-promoting complex subunit 2

0.377

ERO1A_HUMAN

ERO1-like protein alpha

0.379

ERO1B_HUMAN

ERO1-like protein beta

0.379

CUL3_HUMAN

Cullin-3

0.379

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.379

MFRN2_HUMAN

Mitoferrin-2

0.380

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.380

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.380

MFRN1_HUMAN

Mitoferrin-1

0.382

VPS16_HUMAN

Vacuolar protein sorting-associated protein 16 homolog

0.382

EBP2_HUMAN

Probable rRNA-processing protein EBP2

0.382

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.383

CYB5_HUMAN

Cytochrome b5

0.383

WDHD1_HUMAN

WD repeat and HMG-box DNA-binding protein 1

0.384

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.384

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.385

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.386

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.386

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.386

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.386

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.386

PA2G4_HUMAN

Proliferation-associated protein 2G4

0.386

RPOM_HUMAN

DNA-directed RNA polymerase, mitochondrial

0.386

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.386

VTA1_HUMAN

Vacuolar protein sorting-associated protein VTA1 homolog

0.387

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.388

UCHL3_HUMAN

Ubiquitin carboxyl-terminal hydrolase isozyme L3

0.388

MPC1_HUMAN

Mitochondrial pyruvate carrier 1

0.388

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.388

TMEDA_HUMAN

Transmembrane emp24 domain-containing protein 10

0.389

BRAP_HUMAN

BRCA1-associated protein

0.390

STAG1_HUMAN

Cohesin subunit SA-1

0.390

VPS39_HUMAN

Vam6/Vps39-like protein

0.392

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.393

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.393

TBCD_HUMAN

Tubulin-specific chaperone D

0.393

TIPRL_HUMAN

TIP41-like protein

0.394

AP3D1_HUMAN

AP-3 complex subunit delta-1

0.394

S36A4_HUMAN

Proton-coupled amino acid transporter 4

0.394

AMPD2_HUMAN

AMP deaminase 2

0.395

EMC3_HUMAN

ER membrane protein complex subunit 3

0.395

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.395

ALG8_HUMAN

Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

0.396

NOC4L_HUMAN

Nucleolar complex protein 4 homolog

0.396

EMC2_HUMAN

ER membrane protein complex subunit 2

0.397

VAC14_HUMAN

Protein VAC14 homolog

0.397

ALG12_HUMAN

Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

0.398

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.399

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.400

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.400

VPS54_HUMAN

Vacuolar protein sorting-associated protein 54

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 134 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy