DPH6_HUMAN 2019

Gene Name DPH6

Description Diphthine--ammonia ligase

Length 267

9606

Sequence

>sp|Q7L8W6|DPH6_HUMAN Diphthine--ammonia ligase
MRVAALISGGKDSCYNMMQCIAAGHQIVALANLRPAENQVGSDELDSYMYQTVGHHAIDLYAEAMALPLYRRTIRGRSLDTRQVYTKCEGDEVEDLYELLKLVKEKEEVEGISVGAILSDYQRIRVENVCKRLNLQPLAYLWQRNQEDLLREMISSNIQAMIIKVAALGLDPDKHLGKTLDQMEPYLIELSKKYGVHVCGEGGEYETFTLDCPLFKKKIIVDSSEVVIHSADAFAPVAYLRFLELHLEDKVSSVPDNYRTSNYIYNF

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

RPAB1_HUMAN

DNA-directed RNA polymerases I, II, and III subunit RPABC1

0.293

DPH1_HUMAN

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

0.295

S61A1_HUMAN

Protein transport protein Sec61 subunit alpha isoform 1

0.300

MAP2_HUMAN

Methionine aminopeptidase 2

0.300

RL4_HUMAN

60S ribosomal protein L4

0.301

RS4X_HUMAN

40S ribosomal protein S4, X isoform

0.301

RL3_HUMAN

60S ribosomal protein L3

0.309

TRM5_HUMAN

tRNA (guanine(37)-N1)-methyltransferase

0.309

SYWC_HUMAN

Tryptophan--tRNA ligase, cytoplasmic

0.309

PCNA_HUMAN

Proliferating cell nuclear antigen

0.309

RL10_HUMAN

60S ribosomal protein L10

0.315

ERF1_HUMAN

Eukaryotic peptide chain release factor subunit 1

0.316

RLA0_HUMAN

60S acidic ribosomal protein P0

0.317

TBP_HUMAN

TATA-box-binding protein

0.318

IF2A_HUMAN

Eukaryotic translation initiation factor 2 subunit 1

0.322

RL26_HUMAN

60S ribosomal protein L26

0.323

IF2G_HUMAN

Eukaryotic translation initiation factor 2 subunit 3

0.323

SBDS_HUMAN

Ribosome maturation protein SBDS

0.324

DPH5_HUMAN

Diphthine methyl ester synthase

0.326

FEN1_HUMAN

Flap endonuclease 1

0.329

RL8_HUMAN

60S ribosomal protein L8

0.330

RSSA_HUMAN

40S ribosomal protein SA

0.331

RS3A_HUMAN

40S ribosomal protein S3a

0.331

IF6_HUMAN

Eukaryotic translation initiation factor 6

0.332

RS23_HUMAN

40S ribosomal protein S23

0.337

RL13A_HUMAN

60S ribosomal protein L13a

0.337

IF2B_HUMAN

Eukaryotic translation initiation factor 2 subunit 2

0.338

RL5_HUMAN

60S ribosomal protein L5

0.338

NOP56_HUMAN

Nucleolar protein 56

0.338

TCPG_HUMAN

T-complex protein 1 subunit gamma

0.338

RL19_HUMAN

60S ribosomal protein L19

0.339

RL37A_HUMAN

60S ribosomal protein L37a

0.340

EF2_HUMAN

Elongation factor 2

0.343

TRM1_HUMAN

tRNA (guanine(26)-N(2))-dimethyltransferase

0.343

SYLC_HUMAN

Leucine--tRNA ligase, cytoplasmic

0.345

RL32_HUMAN

60S ribosomal protein L32

0.345

RS16_HUMAN

40S ribosomal protein S16

0.348

SRPRA_HUMAN

Signal recognition particle receptor subunit alpha

0.349

PTH2_HUMAN

Peptidyl-tRNA hydrolase 2, mitochondrial

0.350

NOG1_HUMAN

Nucleolar GTP-binding protein 1

0.351

RPAB2_HUMAN

DNA-directed RNA polymerases I, II, and III subunit RPABC2

0.352

RS5_HUMAN

40S ribosomal protein S5

0.352

RS6_HUMAN

40S ribosomal protein S6

0.358

NH2L1_HUMAN

NHP2-like protein 1

0.358

RL15_HUMAN

60S ribosomal protein L15

0.358

IF1AX_HUMAN

Eukaryotic translation initiation factor 1A, X-chromosomal

0.359

RL10A_HUMAN

60S ribosomal protein L10a

0.363

DKC1_HUMAN

H/ACA ribonucleoprotein complex subunit DKC1

0.363

S61A2_HUMAN

Protein transport protein Sec61 subunit alpha isoform 2

0.364

IF2GL_HUMAN

Eukaryotic translation initiation factor 2 subunit 3B

0.364

NOP58_HUMAN

Nucleolar protein 58

0.364

RLA0L_HUMAN

60S acidic ribosomal protein P0-like

0.366

TF2B_HUMAN

Transcription initiation factor IIB

0.367

RPB3_HUMAN

DNA-directed RNA polymerase II subunit RPB3

0.371

RL10L_HUMAN

60S ribosomal protein L10-like

0.371

PELO_HUMAN

Protein pelota homolog

0.371

RS13_HUMAN

40S ribosomal protein S13

0.372

MCM4_HUMAN

DNA replication licensing factor MCM4

0.372

RS19_HUMAN

40S ribosomal protein S19

0.372

SYDC_HUMAN

Aspartate--tRNA ligase, cytoplasmic

0.372

RS17_HUMAN

40S ribosomal protein S17

0.373

RL26L_HUMAN

60S ribosomal protein L26-like 1

0.383

RLP24_HUMAN

Probable ribosome biogenesis protein RLP24

0.384

RIOK1_HUMAN

Serine/threonine-protein kinase RIO1

0.390

RS8_HUMAN

40S ribosomal protein S8

0.391

TBPL2_HUMAN

TATA box-binding protein-like protein 2

0.391

IF5A1_HUMAN

Eukaryotic translation initiation factor 5A-1

0.395

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.395

IF2P_HUMAN

Eukaryotic translation initiation factor 5B

0.396

EXOS2_HUMAN

Exosome complex component RRP4

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RPAB1_HUMAN

DNA-directed RNA polymerases I, II, and III subunit RPABC1

0.293

DPH1_HUMAN

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

0.295

S61A1_HUMAN

Protein transport protein Sec61 subunit alpha isoform 1

0.300

MAP2_HUMAN

Methionine aminopeptidase 2

0.300

RL4_HUMAN

60S ribosomal protein L4

0.301

RS4X_HUMAN

40S ribosomal protein S4, X isoform

0.301

RL3_HUMAN

60S ribosomal protein L3

0.309

TRM5_HUMAN

tRNA (guanine(37)-N1)-methyltransferase

0.309

SYWC_HUMAN

Tryptophan--tRNA ligase, cytoplasmic

0.309

PCNA_HUMAN

Proliferating cell nuclear antigen

0.309

RL10_HUMAN

60S ribosomal protein L10

0.315

ERF1_HUMAN

Eukaryotic peptide chain release factor subunit 1

0.316

RLA0_HUMAN

60S acidic ribosomal protein P0

0.317

TBP_HUMAN

TATA-box-binding protein

0.318

IF2A_HUMAN

Eukaryotic translation initiation factor 2 subunit 1

0.322

RL26_HUMAN

60S ribosomal protein L26

0.323

IF2G_HUMAN

Eukaryotic translation initiation factor 2 subunit 3

0.323

SBDS_HUMAN

Ribosome maturation protein SBDS

0.324

DPH5_HUMAN

Diphthine methyl ester synthase

0.326

FEN1_HUMAN

Flap endonuclease 1

0.329

RL8_HUMAN

60S ribosomal protein L8

0.330

RSSA_HUMAN

40S ribosomal protein SA

0.331

RS3A_HUMAN

40S ribosomal protein S3a

0.331

IF6_HUMAN

Eukaryotic translation initiation factor 6

0.332

RS23_HUMAN

40S ribosomal protein S23

0.337

RL13A_HUMAN

60S ribosomal protein L13a

0.337

IF2B_HUMAN

Eukaryotic translation initiation factor 2 subunit 2

0.338

RL5_HUMAN

60S ribosomal protein L5

0.338

NOP56_HUMAN

Nucleolar protein 56

0.338

TCPG_HUMAN

T-complex protein 1 subunit gamma

0.338

RL19_HUMAN

60S ribosomal protein L19

0.339

RL37A_HUMAN

60S ribosomal protein L37a

0.340

EF2_HUMAN

Elongation factor 2

0.343

TRM1_HUMAN

tRNA (guanine(26)-N(2))-dimethyltransferase

0.343

SYLC_HUMAN

Leucine--tRNA ligase, cytoplasmic

0.345

RL32_HUMAN

60S ribosomal protein L32

0.345

RS16_HUMAN

40S ribosomal protein S16

0.348

SRPRA_HUMAN

Signal recognition particle receptor subunit alpha

0.349

PTH2_HUMAN

Peptidyl-tRNA hydrolase 2, mitochondrial

0.350

NOG1_HUMAN

Nucleolar GTP-binding protein 1

0.351

RPAB2_HUMAN

DNA-directed RNA polymerases I, II, and III subunit RPABC2

0.352

RS5_HUMAN

40S ribosomal protein S5

0.352

RS6_HUMAN

40S ribosomal protein S6

0.358

NH2L1_HUMAN

NHP2-like protein 1

0.358

RL15_HUMAN

60S ribosomal protein L15

0.358

IF1AX_HUMAN

Eukaryotic translation initiation factor 1A, X-chromosomal

0.359

RL10A_HUMAN

60S ribosomal protein L10a

0.363

DKC1_HUMAN

H/ACA ribonucleoprotein complex subunit DKC1

0.363

S61A2_HUMAN

Protein transport protein Sec61 subunit alpha isoform 2

0.364

IF2GL_HUMAN

Eukaryotic translation initiation factor 2 subunit 3B

0.364

NOP58_HUMAN

Nucleolar protein 58

0.364

RLA0L_HUMAN

60S acidic ribosomal protein P0-like

0.366

TF2B_HUMAN

Transcription initiation factor IIB

0.367

RPB3_HUMAN

DNA-directed RNA polymerase II subunit RPB3

0.371

RL10L_HUMAN

60S ribosomal protein L10-like

0.371

PELO_HUMAN

Protein pelota homolog

0.371

RS13_HUMAN

40S ribosomal protein S13

0.372

MCM4_HUMAN

DNA replication licensing factor MCM4

0.372

RS19_HUMAN

40S ribosomal protein S19

0.372

SYDC_HUMAN

Aspartate--tRNA ligase, cytoplasmic

0.372

RS17_HUMAN

40S ribosomal protein S17

0.373

RL26L_HUMAN

60S ribosomal protein L26-like 1

0.383

RLP24_HUMAN

Probable ribosome biogenesis protein RLP24

0.384

RIOK1_HUMAN

Serine/threonine-protein kinase RIO1

0.390

RS8_HUMAN

40S ribosomal protein S8

0.391

TBPL2_HUMAN

TATA box-binding protein-like protein 2

0.391

IF5A1_HUMAN

Eukaryotic translation initiation factor 5A-1

0.395

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.395

IF2P_HUMAN

Eukaryotic translation initiation factor 5B

0.396

EXOS2_HUMAN

Exosome complex component RRP4

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 202 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy