MIRO2_HUMAN 2019

Gene Name MIRO2

Description Mitochondrial Rho GTPase 2

Length 618

9606

Sequence

>sp|Q8IXI1|MIRO2_HUMAN Mitochondrial Rho GTPase 2
MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.269

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.352

ELP1_HUMAN

Elongator complex protein 1

0.356

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.362

VPS25_HUMAN

Vacuolar protein-sorting-associated protein 25

0.363

ALG6_HUMAN

Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

0.367

TMEDA_HUMAN

Transmembrane emp24 domain-containing protein 10

0.368

PP6R3_HUMAN

Serine/threonine-protein phosphatase 6 regulatory subunit 3

0.371

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.373

VTI1A_HUMAN

Vesicle transport through interaction with t-SNAREs homolog 1A

0.379

DAD1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

0.383

HS74L_HUMAN

Heat shock 70 kDa protein 4L

0.386

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.387

VPS39_HUMAN

Vam6/Vps39-like protein

0.387

LST8_HUMAN

Target of rapamycin complex subunit LST8

0.387

HS105_HUMAN

Heat shock protein 105 kDa

0.387

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.388

ALG1_HUMAN

Chitobiosyldiphosphodolichol beta-mannosyltransferase

0.389

TFP11_HUMAN

Tuftelin-interacting protein 11

0.390

TIPRL_HUMAN

TIP41-like protein

0.390

STK38_HUMAN

Serine/threonine-protein kinase 38

0.390

CAP2_HUMAN

Adenylyl cyclase-associated protein 2

0.392

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.392

CHMP5_HUMAN

Charged multivesicular body protein 5

0.393

CAB39_HUMAN

Calcium-binding protein 39

0.393

MFRN1_HUMAN

Mitoferrin-1

0.393

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.394

CB39L_HUMAN

Calcium-binding protein 39-like

0.394

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.394

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.396

VPS28_HUMAN

Vacuolar protein sorting-associated protein 28 homolog

0.397

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.397

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.397

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.397

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.397

UBE2N_HUMAN

Ubiquitin-conjugating enzyme E2 N

0.397

S36A2_HUMAN

Proton-coupled amino acid transporter 2

0.398

FXL20_HUMAN

F-box/LRR-repeat protein 20

0.398

C19L2_HUMAN

CWF19-like protein 2

0.398

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.399

BRDT_HUMAN

Bromodomain testis-specific protein

0.400

PP6R2_HUMAN

Serine/threonine-protein phosphatase 6 regulatory subunit 2

0.400

SMRD3_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

0.400

SMAP1_HUMAN

Stromal membrane-associated protein 1

0.400

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.400

HEAT1_HUMAN

HEAT repeat-containing protein 1

0.400

SMAP2_HUMAN

Stromal membrane-associated protein 2

0.400

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.269

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.352

ELP1_HUMAN

Elongator complex protein 1

0.356

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.362

VPS25_HUMAN

Vacuolar protein-sorting-associated protein 25

0.363

ALG6_HUMAN

Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

0.367

TMEDA_HUMAN

Transmembrane emp24 domain-containing protein 10

0.368

PP6R3_HUMAN

Serine/threonine-protein phosphatase 6 regulatory subunit 3

0.371

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.373

VTI1A_HUMAN

Vesicle transport through interaction with t-SNAREs homolog 1A

0.379

DAD1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

0.383

HS74L_HUMAN

Heat shock 70 kDa protein 4L

0.386

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.387

VPS39_HUMAN

Vam6/Vps39-like protein

0.387

LST8_HUMAN

Target of rapamycin complex subunit LST8

0.387

HS105_HUMAN

Heat shock protein 105 kDa

0.387

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.388

ALG1_HUMAN

Chitobiosyldiphosphodolichol beta-mannosyltransferase

0.389

TFP11_HUMAN

Tuftelin-interacting protein 11

0.390

TIPRL_HUMAN

TIP41-like protein

0.390

STK38_HUMAN

Serine/threonine-protein kinase 38

0.390

CAP2_HUMAN

Adenylyl cyclase-associated protein 2

0.392

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.392

CHMP5_HUMAN

Charged multivesicular body protein 5

0.393

CAB39_HUMAN

Calcium-binding protein 39

0.393

MFRN1_HUMAN

Mitoferrin-1

0.393

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.394

CB39L_HUMAN

Calcium-binding protein 39-like

0.394

RPTOR_HUMAN

Regulatory-associated protein of mTOR

0.394

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.396

VPS28_HUMAN

Vacuolar protein sorting-associated protein 28 homolog

0.397

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.397

CAP1_HUMAN

Adenylyl cyclase-associated protein 1

0.397

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.397

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.397

UBE2N_HUMAN

Ubiquitin-conjugating enzyme E2 N

0.397

S36A2_HUMAN

Proton-coupled amino acid transporter 2

0.398

FXL20_HUMAN

F-box/LRR-repeat protein 20

0.398

C19L2_HUMAN

CWF19-like protein 2

0.398

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.399

BRDT_HUMAN

Bromodomain testis-specific protein

0.400

PP6R2_HUMAN

Serine/threonine-protein phosphatase 6 regulatory subunit 2

0.400

SMRD3_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

0.400

SMAP1_HUMAN

Stromal membrane-associated protein 1

0.400

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.400

HEAT1_HUMAN

HEAT repeat-containing protein 1

0.400

SMAP2_HUMAN

Stromal membrane-associated protein 2

0.400

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 129 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy