S2540_HUMAN 2019

Gene Name S2540

Description Solute carrier family 25 member 40

Length 338

9606

Sequence

>sp|Q8TBP6|S2540_HUMAN Solute carrier family 25 member 40
MDPETRGQEIIKVTPLQQMLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNGLMDHLCVCEEGGNKLWYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKLGENETCIPIVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVSKKVSEDGWISLWRGWAPTVLRDVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIKIAPACAIMISTYEFGKAFFQKQNVRRQQY

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

S2539_HUMAN

Solute carrier family 25 member 39

0.282

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.355

CNOT2_HUMAN

CCR4-NOT transcription complex subunit 2

0.360

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.363

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.365

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.368

TIM44_HUMAN

Mitochondrial import inner membrane translocase subunit TIM44

0.370

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.375

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.377

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.377

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.378

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.379

RPOM_HUMAN

DNA-directed RNA polymerase, mitochondrial

0.379

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.379

RANB9_HUMAN

Ran-binding protein 9

0.379

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.380

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.380

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.380

CSTF3_HUMAN

Cleavage stimulation factor subunit 3

0.380

DMXL2_HUMAN

DmX-like protein 2

0.382

TPC2B_HUMAN

Trafficking protein particle complex subunit 2B

0.383

TPC2A_HUMAN

Trafficking protein particle complex subunit 2

0.383

THOC2_HUMAN

THO complex subunit 2

0.383

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.383

OTU6B_HUMAN

Deubiquitinase OTUD6B

0.384

TI17B_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-B

0.386

CWC15_HUMAN

Spliceosome-associated protein CWC15 homolog

0.386

SNW1_HUMAN

SNW domain-containing protein 1

0.386

FNTA_HUMAN

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

0.386

KDM5C_HUMAN

Lysine-specific demethylase 5C

0.387

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.388

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.388

KCC1A_HUMAN

Calcium/calmodulin-dependent protein kinase type 1

0.388

KCC1D_HUMAN

Calcium/calmodulin-dependent protein kinase type 1D

0.389

COG4_HUMAN

Conserved oligomeric Golgi complex subunit 4

0.389

KRI1_HUMAN

Protein KRI1 homolog

0.390

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.392

RAB6A_HUMAN

Ras-related protein Rab-6A

0.393

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.393

SC22B_HUMAN

Vesicle-trafficking protein SEC22b

0.393

RBP10_HUMAN

Ran-binding protein 10

0.394

PA2G4_HUMAN

Proliferation-associated protein 2G4

0.395

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.395

C19L2_HUMAN

CWF19-like protein 2

0.396

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.396

CDC73_HUMAN

Parafibromin

0.396

H2A2B_HUMAN

Histone H2A type 2-B

0.396

PSME4_HUMAN

Proteasome activator complex subunit 4

0.397

ADT2_HUMAN

ADP/ATP translocase 2

0.397

DPOA2_HUMAN

DNA polymerase alpha subunit B

0.399

P4R3B_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3B

0.399

PSA1_HUMAN

Proteasome subunit alpha type-1

0.399

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.399

TAZ_HUMAN

Tafazzin

0.400

TBCE_HUMAN

Tubulin-specific chaperone E

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

S2539_HUMAN

Solute carrier family 25 member 39

0.282

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.355

CNOT2_HUMAN

CCR4-NOT transcription complex subunit 2

0.360

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.363

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.365

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.368

TIM44_HUMAN

Mitochondrial import inner membrane translocase subunit TIM44

0.370

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.375

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.377

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.377

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.378

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.379

RPOM_HUMAN

DNA-directed RNA polymerase, mitochondrial

0.379

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.379

RANB9_HUMAN

Ran-binding protein 9

0.379

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.380

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.380

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.380

CSTF3_HUMAN

Cleavage stimulation factor subunit 3

0.380

DMXL2_HUMAN

DmX-like protein 2

0.382

TPC2B_HUMAN

Trafficking protein particle complex subunit 2B

0.383

TPC2A_HUMAN

Trafficking protein particle complex subunit 2

0.383

THOC2_HUMAN

THO complex subunit 2

0.383

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.383

OTU6B_HUMAN

Deubiquitinase OTUD6B

0.384

TI17B_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-B

0.386

CWC15_HUMAN

Spliceosome-associated protein CWC15 homolog

0.386

SNW1_HUMAN

SNW domain-containing protein 1

0.386

FNTA_HUMAN

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

0.386

KDM5C_HUMAN

Lysine-specific demethylase 5C

0.387

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.388

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.388

KCC1A_HUMAN

Calcium/calmodulin-dependent protein kinase type 1

0.388

KCC1D_HUMAN

Calcium/calmodulin-dependent protein kinase type 1D

0.389

COG4_HUMAN

Conserved oligomeric Golgi complex subunit 4

0.389

KRI1_HUMAN

Protein KRI1 homolog

0.390

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.392

RAB6A_HUMAN

Ras-related protein Rab-6A

0.393

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.393

SC22B_HUMAN

Vesicle-trafficking protein SEC22b

0.393

RBP10_HUMAN

Ran-binding protein 10

0.394

PA2G4_HUMAN

Proliferation-associated protein 2G4

0.395

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.395

C19L2_HUMAN

CWF19-like protein 2

0.396

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.396

CDC73_HUMAN

Parafibromin

0.396

H2A2B_HUMAN

Histone H2A type 2-B

0.396

PSME4_HUMAN

Proteasome activator complex subunit 4

0.397

ADT2_HUMAN

ADP/ATP translocase 2

0.397

DPOA2_HUMAN

DNA polymerase alpha subunit B

0.399

P4R3B_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3B

0.399

PSA1_HUMAN

Proteasome subunit alpha type-1

0.399

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.399

TAZ_HUMAN

Tafazzin

0.400

TBCE_HUMAN

Tubulin-specific chaperone E

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 133 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy