CCD12_HUMAN 2019

Gene Name CCD12

Description Coiled-coil domain-containing protein 12

Length 166

9606

Sequence

>sp|Q8WUD4|CCD12_HUMAN Coiled-coil domain-containing protein 12
MEATTAGVGRLEEEALRRKERLKALREKTGRKDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAVDAATEQKTCDSD

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

C19L2_HUMAN

CWF19-like protein 2

0.336

RANB9_HUMAN

Ran-binding protein 9

0.355

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.355

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.362

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.369

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.373

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.374

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.374

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.375

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.375

RL28_HUMAN

60S ribosomal protein L28

0.377

NOSIP_HUMAN

Nitric oxide synthase-interacting protein

0.377

ESS2_HUMAN

Splicing factor ESS-2 homolog

0.378

MAEA_HUMAN

E3 ubiquitin-protein transferase MAEA

0.381

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.382

MFRN2_HUMAN

Mitoferrin-2

0.383

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.383

SNR40_HUMAN

U5 small nuclear ribonucleoprotein 40 kDa protein

0.384

RBM22_HUMAN

Pre-mRNA-splicing factor RBM22

0.384

CTBL1_HUMAN

Beta-catenin-like protein 1

0.386

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.387

WDR70_HUMAN

WD repeat-containing protein 70

0.387

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.388

RBP10_HUMAN

Ran-binding protein 10

0.388

MFAP1_HUMAN

Microfibrillar-associated protein 1

0.388

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.388

RBM8A_HUMAN

RNA-binding protein 8A

0.388

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.389

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.389

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.389

SRP68_HUMAN

Signal recognition particle subunit SRP68

0.389

WDR83_HUMAN

WD repeat domain-containing protein 83

0.390

YPEL1_HUMAN

Protein yippee-like 1

0.390

THOC3_HUMAN

THO complex subunit 3

0.392

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.392

TCEA1_HUMAN

Transcription elongation factor A protein 1

0.393

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.393

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.394

KDM5B_HUMAN

Lysine-specific demethylase 5B

0.396

BUD13_HUMAN

BUD13 homolog

0.396

SNW1_HUMAN

SNW domain-containing protein 1

0.396

KDM5C_HUMAN

Lysine-specific demethylase 5C

0.397

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.397

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.398

WDR26_HUMAN

WD repeat-containing protein 26

0.400

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.400

FA50A_HUMAN

Protein FAM50A

0.400

GID8_HUMAN

Glucose-induced degradation protein 8 homolog

0.400

VIP2_HUMAN

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

0.400

VAC14_HUMAN

Protein VAC14 homolog

0.400

MFRN1_HUMAN

Mitoferrin-1

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

C19L2_HUMAN

CWF19-like protein 2

0.336

RANB9_HUMAN

Ran-binding protein 9

0.355

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.355

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.362

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.369

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.373

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.374

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.374

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.375

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.375

RL28_HUMAN

60S ribosomal protein L28

0.377

NOSIP_HUMAN

Nitric oxide synthase-interacting protein

0.377

ESS2_HUMAN

Splicing factor ESS-2 homolog

0.378

MAEA_HUMAN

E3 ubiquitin-protein transferase MAEA

0.381

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.382

MFRN2_HUMAN

Mitoferrin-2

0.383

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.383

SNR40_HUMAN

U5 small nuclear ribonucleoprotein 40 kDa protein

0.384

RBM22_HUMAN

Pre-mRNA-splicing factor RBM22

0.384

CTBL1_HUMAN

Beta-catenin-like protein 1

0.386

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.387

WDR70_HUMAN

WD repeat-containing protein 70

0.387

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.388

RBP10_HUMAN

Ran-binding protein 10

0.388

MFAP1_HUMAN

Microfibrillar-associated protein 1

0.388

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.388

RBM8A_HUMAN

RNA-binding protein 8A

0.388

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.389

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.389

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.389

SRP68_HUMAN

Signal recognition particle subunit SRP68

0.389

WDR83_HUMAN

WD repeat domain-containing protein 83

0.390

YPEL1_HUMAN

Protein yippee-like 1

0.390

THOC3_HUMAN

THO complex subunit 3

0.392

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.392

TCEA1_HUMAN

Transcription elongation factor A protein 1

0.393

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.393

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.394

KDM5B_HUMAN

Lysine-specific demethylase 5B

0.396

BUD13_HUMAN

BUD13 homolog

0.396

SNW1_HUMAN

SNW domain-containing protein 1

0.396

KDM5C_HUMAN

Lysine-specific demethylase 5C

0.397

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.397

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.398

WDR26_HUMAN

WD repeat-containing protein 26

0.400

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.400

FA50A_HUMAN

Protein FAM50A

0.400

GID8_HUMAN

Glucose-induced degradation protein 8 homolog

0.400

VIP2_HUMAN

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

0.400

VAC14_HUMAN

Protein VAC14 homolog

0.400

MFRN1_HUMAN

Mitoferrin-1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 130 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy