REXO4_HUMAN 2019

Gene Name REXO4

Description RNA exonuclease 4

Length 422

9606

Sequence

>sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4
MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPPKAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRKAKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGLTRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPENLKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSDDA

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.349

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.362

SIN3A_HUMAN

Paired amphipathic helix protein Sin3a

0.363

RL1D1_HUMAN

Ribosomal L1 domain-containing protein 1

0.366

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.369

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.370

CSTF3_HUMAN

Cleavage stimulation factor subunit 3

0.370

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.372

HS74L_HUMAN

Heat shock 70 kDa protein 4L

0.373

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.377

PDC6I_HUMAN

Programmed cell death 6-interacting protein

0.378

HSF1_HUMAN

Heat shock factor protein 1

0.380

SIN3B_HUMAN

Paired amphipathic helix protein Sin3b

0.382

CB39L_HUMAN

Calcium-binding protein 39-like

0.382

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.382

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.384

TTK_HUMAN

Dual specificity protein kinase TTK

0.384

SAMC_HUMAN

S-adenosylmethionine mitochondrial carrier protein

0.384

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.385

EPC2_HUMAN

Enhancer of polycomb homolog 2

0.386

CDC73_HUMAN

Parafibromin

0.386

NOC3L_HUMAN

Nucleolar complex protein 3 homolog

0.386

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.386

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.389

ORC2_HUMAN

Origin recognition complex subunit 2

0.389

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.389

OTU6B_HUMAN

Deubiquitinase OTUD6B

0.390

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.390

S36A1_HUMAN

Proton-coupled amino acid transporter 1

0.390

HS105_HUMAN

Heat shock protein 105 kDa

0.390

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.392

SNW1_HUMAN

SNW domain-containing protein 1

0.392

TIM44_HUMAN

Mitochondrial import inner membrane translocase subunit TIM44

0.393

TFP11_HUMAN

Tuftelin-interacting protein 11

0.393

S36A4_HUMAN

Proton-coupled amino acid transporter 4

0.393

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.393

STK38_HUMAN

Serine/threonine-protein kinase 38

0.393

ST38L_HUMAN

Serine/threonine-protein kinase 38-like

0.393

MOGT2_HUMAN

2-acylglycerol O-acyltransferase 2

0.394

MFRN2_HUMAN

Mitoferrin-2

0.395

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.395

SEC13_HUMAN

Protein SEC13 homolog

0.395

NCBP1_HUMAN

Nuclear cap-binding protein subunit 1

0.396

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.396

CAB39_HUMAN

Calcium-binding protein 39

0.396

PSD13_HUMAN

26S proteasome non-ATPase regulatory subunit 13

0.397

HSF2_HUMAN

Heat shock factor protein 2

0.397

HSF4_HUMAN

Heat shock factor protein 4

0.397

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.398

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.399

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.399

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.399

UBP13_HUMAN

Ubiquitin carboxyl-terminal hydrolase 13

0.399

ORC4_HUMAN

Origin recognition complex subunit 4

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.349

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.362

SIN3A_HUMAN

Paired amphipathic helix protein Sin3a

0.363

RL1D1_HUMAN

Ribosomal L1 domain-containing protein 1

0.366

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.369

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.370

CSTF3_HUMAN

Cleavage stimulation factor subunit 3

0.370

DMAP1_HUMAN

DNA methyltransferase 1-associated protein 1

0.372

HS74L_HUMAN

Heat shock 70 kDa protein 4L

0.373

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.377

PDC6I_HUMAN

Programmed cell death 6-interacting protein

0.378

HSF1_HUMAN

Heat shock factor protein 1

0.380

SIN3B_HUMAN

Paired amphipathic helix protein Sin3b

0.382

CB39L_HUMAN

Calcium-binding protein 39-like

0.382

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.382

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.384

TTK_HUMAN

Dual specificity protein kinase TTK

0.384

SAMC_HUMAN

S-adenosylmethionine mitochondrial carrier protein

0.384

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.385

EPC2_HUMAN

Enhancer of polycomb homolog 2

0.386

CDC73_HUMAN

Parafibromin

0.386

NOC3L_HUMAN

Nucleolar complex protein 3 homolog

0.386

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.386

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.389

ORC2_HUMAN

Origin recognition complex subunit 2

0.389

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.389

OTU6B_HUMAN

Deubiquitinase OTUD6B

0.390

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.390

S36A1_HUMAN

Proton-coupled amino acid transporter 1

0.390

HS105_HUMAN

Heat shock protein 105 kDa

0.390

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.392

SNW1_HUMAN

SNW domain-containing protein 1

0.392

TIM44_HUMAN

Mitochondrial import inner membrane translocase subunit TIM44

0.393

TFP11_HUMAN

Tuftelin-interacting protein 11

0.393

S36A4_HUMAN

Proton-coupled amino acid transporter 4

0.393

TRRAP_HUMAN

Transformation/transcription domain-associated protein

0.393

STK38_HUMAN

Serine/threonine-protein kinase 38

0.393

ST38L_HUMAN

Serine/threonine-protein kinase 38-like

0.393

MOGT2_HUMAN

2-acylglycerol O-acyltransferase 2

0.394

MFRN2_HUMAN

Mitoferrin-2

0.395

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.395

SEC13_HUMAN

Protein SEC13 homolog

0.395

NCBP1_HUMAN

Nuclear cap-binding protein subunit 1

0.396

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.396

CAB39_HUMAN

Calcium-binding protein 39

0.396

PSD13_HUMAN

26S proteasome non-ATPase regulatory subunit 13

0.397

HSF2_HUMAN

Heat shock factor protein 2

0.397

HSF4_HUMAN

Heat shock factor protein 4

0.397

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.398

HAT1_HUMAN

Histone acetyltransferase type B catalytic subunit

0.399

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.399

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.399

UBP13_HUMAN

Ubiquitin carboxyl-terminal hydrolase 13

0.399

ORC4_HUMAN

Origin recognition complex subunit 4

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 136 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy