CCNL1_HUMAN 2019

Gene Name CCNL1

Description Cyclin-L1

Length 526

9606

Sequence

>sp|Q9UK58|CCNL1_HUMAN Cyclin-L1
MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.363

SNW1_HUMAN

SNW domain-containing protein 1

0.370

FNTA_HUMAN

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

0.370

CCNL2_HUMAN

Cyclin-L2

0.373

SNR40_HUMAN

U5 small nuclear ribonucleoprotein 40 kDa protein

0.374

CTBL1_HUMAN

Beta-catenin-like protein 1

0.375

EIF3H_HUMAN

Eukaryotic translation initiation factor 3 subunit H

0.377

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.378

BT3L4_HUMAN

Transcription factor BTF3 homolog 4

0.378

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.379

C19L2_HUMAN

CWF19-like protein 2

0.379

ISY1_HUMAN

Pre-mRNA-splicing factor ISY1 homolog

0.380

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.380

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.384

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.386

TBCD_HUMAN

Tubulin-specific chaperone D

0.386

BTF3_HUMAN

Transcription factor BTF3

0.386

CWC22_HUMAN

Pre-mRNA-splicing factor CWC22 homolog

0.388

MFRN2_HUMAN

Mitoferrin-2

0.389

HTSF1_HUMAN

HIV Tat-specific factor 1

0.392

PRPF3_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp3

0.392

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.392

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.392

CLH1_HUMAN

Clathrin heavy chain 1

0.392

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.392

RENT2_HUMAN

Regulator of nonsense transcripts 2

0.393

VTI1A_HUMAN

Vesicle transport through interaction with t-SNAREs homolog 1A

0.393

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.393

RAB6A_HUMAN

Ras-related protein Rab-6A

0.393

ORC4_HUMAN

Origin recognition complex subunit 4

0.394

RBM8A_HUMAN

RNA-binding protein 8A

0.394

SRP68_HUMAN

Signal recognition particle subunit SRP68

0.395

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.395

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.395

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.395

UTP6_HUMAN

U3 small nucleolar RNA-associated protein 6 homolog

0.396

CDC73_HUMAN

Parafibromin

0.396

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.396

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.396

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.397

FIG4_HUMAN

Polyphosphoinositide phosphatase

0.399

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.399

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.399

PSA1_HUMAN

Proteasome subunit alpha type-1

0.399

PLRG1_HUMAN

Pleiotropic regulator 1

0.399

DBR1_HUMAN

Lariat debranching enzyme

0.399

SNAB_HUMAN

Beta-soluble NSF attachment protein

0.399

LST8_HUMAN

Target of rapamycin complex subunit LST8

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

PRP6_HUMAN

Pre-mRNA-processing factor 6

0.363

SNW1_HUMAN

SNW domain-containing protein 1

0.370

FNTA_HUMAN

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

0.370

CCNL2_HUMAN

Cyclin-L2

0.373

SNR40_HUMAN

U5 small nuclear ribonucleoprotein 40 kDa protein

0.374

CTBL1_HUMAN

Beta-catenin-like protein 1

0.375

EIF3H_HUMAN

Eukaryotic translation initiation factor 3 subunit H

0.377

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.378

BT3L4_HUMAN

Transcription factor BTF3 homolog 4

0.378

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.379

C19L2_HUMAN

CWF19-like protein 2

0.379

ISY1_HUMAN

Pre-mRNA-splicing factor ISY1 homolog

0.380

SNUT2_HUMAN

U4/U6.U5 tri-snRNP-associated protein 2

0.380

TI17A_HUMAN

Mitochondrial import inner membrane translocase subunit Tim17-A

0.384

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.386

TBCD_HUMAN

Tubulin-specific chaperone D

0.386

BTF3_HUMAN

Transcription factor BTF3

0.386

CWC22_HUMAN

Pre-mRNA-splicing factor CWC22 homolog

0.388

MFRN2_HUMAN

Mitoferrin-2

0.389

HTSF1_HUMAN

HIV Tat-specific factor 1

0.392

PRPF3_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp3

0.392

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.392

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.392

CLH1_HUMAN

Clathrin heavy chain 1

0.392

PRP17_HUMAN

Pre-mRNA-processing factor 17

0.392

RENT2_HUMAN

Regulator of nonsense transcripts 2

0.393

VTI1A_HUMAN

Vesicle transport through interaction with t-SNAREs homolog 1A

0.393

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.393

RAB6A_HUMAN

Ras-related protein Rab-6A

0.393

ORC4_HUMAN

Origin recognition complex subunit 4

0.394

RBM8A_HUMAN

RNA-binding protein 8A

0.394

SRP68_HUMAN

Signal recognition particle subunit SRP68

0.395

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.395

UB2V2_HUMAN

Ubiquitin-conjugating enzyme E2 variant 2

0.395

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.395

UTP6_HUMAN

U3 small nucleolar RNA-associated protein 6 homolog

0.396

CDC73_HUMAN

Parafibromin

0.396

PRP19_HUMAN

Pre-mRNA-processing factor 19

0.396

PRP4_HUMAN

U4/U6 small nuclear ribonucleoprotein Prp4

0.396

PR40A_HUMAN

Pre-mRNA-processing factor 40 homolog A

0.397

FIG4_HUMAN

Polyphosphoinositide phosphatase

0.399

P4R3A_HUMAN

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

0.399

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.399

PSA1_HUMAN

Proteasome subunit alpha type-1

0.399

PLRG1_HUMAN

Pleiotropic regulator 1

0.399

DBR1_HUMAN

Lariat debranching enzyme

0.399

SNAB_HUMAN

Beta-soluble NSF attachment protein

0.399

LST8_HUMAN

Target of rapamycin complex subunit LST8

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 133 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy