Multiple alignment of complete sequences from BBS6, BBS10 and
BBS12 (chaperonin-like) and other chaperonin group II sequences.
The multiple alignment can be viewed using the Jalview applet
by clicking on "Start Jalview" and then saved under many different
formats.
| Multiple alignment |
|
| BBS12 and mutations |
|
Help:
- Within the multiple alignment, chaperonin subfamilies
are separated by blank sequences using the following format "--[Name of subfamily]--"
(ex: "--BBS12--").
- Sequence accession numbers are mostly from UniProt (http://www.uniprot.org)
and a few from RefSeq
(http://www.ncbi.nih.gov/RefSeq).
Predicted sequences
from genomes are named using the following format "pred_[Name of subfamily]_[Name of
organism]"
ex: pred_BBS12_Cfamiliaris
corresponds to the predicted BBS12 protein sequence
for the dog (Canis
familiaris)
- The complete list of organisms and their aliases are described here.
- Residues participating in nucleotide binding are highlighted
according to interactions with the nucleobase (N), ribose (R), or
phosphate groups (P) (Ditzel et
al Cell 1998) see line in alignment "--ATPBinding--".
- In
the second alignment, point mutations are highlighted in
red. If you do not see any red feature please make sure that "feature
view" is enabled in the "View" menu.
Please
cite us if you use any of this material:
Stoetzel C, Muller J, Laurier V, Davis EE, Zaghloul NA, Vicaire S,
Jacquelin C, Plewniak F, Leitch CC, Sarda P, Hamel C, de Ravel TJ,
Lewis RA, Friederich E, Thibault C, Danse JM, Verloes A, Bonneau D,
Katsanis N, Poch O, Mandel JL, Dollfus H.
Identification of a Novel
BBS gene (BBS12) Highlights the Major Role of a Vertebrate-Specific
Branch of Chaperonin-Related Proteins in Bardet-Biedl Syndrome.
American Journal of Human Genetics. Jan 2007.
Jalview is available at http://www.jalview.org
Please feel free to contact us for any problem or suggestions
(jeanmuller@unistra.fr).