TIM23_HUMAN 2019

Gene Name TIM23

Description Mitochondrial import inner membrane translocase subunit Tim23

Length 209

9606

Sequence

>sp|O14925|TIM23_HUMAN Mitochondrial import inner membrane translocase subunit Tim23
MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEHMKGSLLQQSL

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TI23B_HUMAN

Putative mitochondrial import inner membrane translocase subunit Tim23B

0.357

TBC15_HUMAN

TBC1 domain family member 15

0.370

PICAL_HUMAN

Phosphatidylinositol-binding clathrin assembly protein

0.373

RBBP5_HUMAN

Retinoblastoma-binding protein 5

0.373

SNF5_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

0.379

HMDH_HUMAN

3-hydroxy-3-methylglutaryl-coenzyme A reductase

0.379

UBR7_HUMAN

Putative E3 ubiquitin-protein ligase UBR7

0.380

EXOC5_HUMAN

Exocyst complex component 5

0.380

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.381

PCBP3_HUMAN

Poly(rC)-binding protein 3

0.381

HDHD1_HUMAN

Pseudouridine-5-phosphatase

0.383

FRY_HUMAN

Protein furry homolog

0.383

PDP1_HUMAN

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

0.383

MDHM_HUMAN

Malate dehydrogenase, mitochondrial

0.383

ARPC2_HUMAN

Actin-related protein 2/3 complex subunit 2

0.383

WDR1_HUMAN

WD repeat-containing protein 1

0.384

QCR7_HUMAN

Cytochrome b-c1 complex subunit 7

0.385

MIA40_HUMAN

Mitochondrial intermembrane space import and assembly protein 40

0.385

SYMC_HUMAN

Methionine--tRNA ligase, cytoplasmic

0.385

FRYL_HUMAN

Protein furry homolog-like

0.385

PCBP2_HUMAN

Poly(rC)-binding protein 2

0.386

OSBL8_HUMAN

Oxysterol-binding protein-related protein 8

0.386

AAKG2_HUMAN

5-AMP-activated protein kinase subunit gamma-2

0.387

HTR5B_HUMAN

HEAT repeat-containing protein 5B

0.387

VDAC1_HUMAN

Voltage-dependent anion-selective channel protein 1

0.388

PCBP4_HUMAN

Poly(rC)-binding protein 4

0.388

PRC1_HUMAN

Protein regulator of cytokinesis 1

0.388

TIM44_HUMAN

Mitochondrial import inner membrane translocase subunit TIM44

0.389

HXK4_HUMAN

Glucokinase

0.389

AP180_HUMAN

Clathrin coat assembly protein AP180

0.389

TBC17_HUMAN

TBC1 domain family member 17

0.390

CDC42_HUMAN

Cell division control protein 42 homolog

0.390

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.390

NUP93_HUMAN

Nuclear pore complex protein Nup93

0.390

HXK1_HUMAN

Hexokinase-1

0.390

UMPS_HUMAN

Uridine 5-monophosphate synthase

0.391

ATG2B_HUMAN

Autophagy-related protein 2 homolog B

0.392

XPP3_HUMAN

Xaa-Pro aminopeptidase 3

0.392

GDIR1_HUMAN

Rho GDP-dissociation inhibitor 1

0.392

LST8_HUMAN

Target of rapamycin complex subunit LST8

0.392

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.392

TNPO3_HUMAN

Transportin-3

0.392

VPS8_HUMAN

Vacuolar protein sorting-associated protein 8 homolog

0.392

PUR9_HUMAN

Bifunctional purine biosynthesis protein PURH

0.392

NIPBL_HUMAN

Nipped-B-like protein

0.392

TMED2_HUMAN

Transmembrane emp24 domain-containing protein 2

0.393

NMNA1_HUMAN

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

0.393

GLGB_HUMAN

1,4-alpha-glucan-branching enzyme

0.393

COX5B_HUMAN

Cytochrome c oxidase subunit 5B, mitochondrial

0.393

GATA_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.394

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.394

ELP2_HUMAN

Elongator complex protein 2

0.394

CHM4B_HUMAN

Charged multivesicular body protein 4b

0.394

NAA35_HUMAN

N-alpha-acetyltransferase 35, NatC auxiliary subunit

0.394

BCS1_HUMAN

Mitochondrial chaperone BCS1

0.395

ARPC3_HUMAN

Actin-related protein 2/3 complex subunit 3

0.395

PLST_HUMAN

Plastin-3

0.395

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.395

GLYG_HUMAN

Glycogenin-1

0.395

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.395

EF1B_HUMAN

Elongation factor 1-beta

0.395

PI4KA_HUMAN

Phosphatidylinositol 4-kinase alpha

0.395

ATE1_HUMAN

Arginyl-tRNA--protein transferase 1

0.395

SSDH_HUMAN

Succinate-semialdehyde dehydrogenase, mitochondrial

0.396

MON2_HUMAN

Protein MON2 homolog

0.396

PDP2_HUMAN

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

0.396

PLSL_HUMAN

Plastin-2

0.396

T2AG_HUMAN

Transcription initiation factor IIA subunit 2

0.396

GNAO_HUMAN

Guanine nucleotide-binding protein G(o) subunit alpha

0.396

UGPA_HUMAN

UTP--glucose-1-phosphate uridylyltransferase

0.397

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.397

STK24_HUMAN

Serine/threonine-protein kinase 24

0.397

EXOC6_HUMAN

Exocyst complex component 6

0.397

SSU72_HUMAN

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

0.397

PIGT_HUMAN

GPI transamidase component PIG-T

0.397

BUB1_HUMAN

Mitotic checkpoint serine/threonine-protein kinase BUB1

0.397

GGT3_HUMAN

Putative glutathione hydrolase 3 proenzyme

0.397

STK26_HUMAN

Serine/threonine-protein kinase 26

0.397

PYR1_HUMAN

CAD protein

0.398

SAM50_HUMAN

Sorting and assembly machinery component 50 homolog

0.398

TCTP_HUMAN

Translationally-controlled tumor protein

0.398

BTAF1_HUMAN

TATA-binding protein-associated factor 172

0.398

SYDM_HUMAN

Aspartate--tRNA ligase, mitochondrial

0.398

CAPZB_HUMAN

F-actin-capping protein subunit beta

0.398

GUAA_HUMAN

GMP synthase [glutamine-hydrolyzing]

0.398

RRN3_HUMAN

RNA polymerase I-specific transcription initiation factor RRN3

0.398

UBP46_HUMAN

Ubiquitin carboxyl-terminal hydrolase 46

0.398

APC1_HUMAN

Anaphase-promoting complex subunit 1

0.398

LERL1_HUMAN

Leptin receptor overlapping transcript-like 1

0.398

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.399

CBS_HUMAN

Cystathionine beta-synthase

0.399

DCAM_HUMAN

S-adenosylmethionine decarboxylase proenzyme

0.399

PDS5B_HUMAN

Sister chromatid cohesion protein PDS5 homolog B

0.399

PIGS_HUMAN

GPI transamidase component PIG-S

0.399

MA1B1_HUMAN

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

0.399

TAZ_HUMAN

Tafazzin

0.399

DCAF7_HUMAN

DDB1- and CUL4-associated factor 7

0.399

REXO4_HUMAN

RNA exonuclease 4

0.399

GGT1_HUMAN

Glutathione hydrolase 1 proenzyme

0.399

SERC1_HUMAN

Serine incorporator 1

0.399

MAGT1_HUMAN

Magnesium transporter protein 1

0.400

MVD1_HUMAN

Diphosphomevalonate decarboxylase

0.400

TIPRL_HUMAN

TIP41-like protein

0.400

ODP2_HUMAN

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

0.400

EF1G_HUMAN

Elongation factor 1-gamma

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 112 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy