DRC4_HUMAN 2019

Gene Name DRC4

Description Dynein regulatory complex subunit 4

Length 478

9606

Sequence

>sp|O95995|DRC4_HUMAN Dynein regulatory complex subunit 4
MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TILB_HUMAN

Protein tilB homolog

0.218

CFA52_HUMAN

Cilia- and flagella-associated protein 52

0.221

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.221

ZMY10_HUMAN

Zinc finger MYND domain-containing protein 10

0.243

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.245

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.247

DRC11_HUMAN

Dynein regulatory complex protein 11

0.247

PACRG_HUMAN

Parkin coregulated gene protein

0.266

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.269

DNAL1_HUMAN

Dynein light chain 1, axonemal

0.271

WDR63_HUMAN

WD repeat-containing protein 63

0.271

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.271

ENKUR_HUMAN

Enkurin

0.292

CCD39_HUMAN

Coiled-coil domain-containing protein 39

0.292

EFHC1_HUMAN

EF-hand domain-containing protein 1

0.305

DNAI2_HUMAN

Dynein intermediate chain 2, axonemal

0.309

CFA58_HUMAN

Cilia- and flagella-associated protein 58

0.312

RSH4A_HUMAN

Radial spoke head protein 4 homolog A

0.312

RSPH9_HUMAN

Radial spoke head protein 9 homolog

0.312

CB5D1_HUMAN

Cytochrome b5 domain-containing protein 1

0.312

IFT46_HUMAN

Intraflagellar transport protein 46 homolog

0.320

IFT57_HUMAN

Intraflagellar transport protein 57 homolog

0.322

DAAF5_HUMAN

Dynein assembly factor 5, axonemal

0.325

SPAG6_HUMAN

Sperm-associated antigen 6

0.327

DNAI1_HUMAN

Dynein intermediate chain 1, axonemal

0.327

HYDIN_HUMAN

Hydrocephalus-inducing protein homolog

0.329

CFA45_HUMAN

Cilia- and flagella-associated protein 45

0.331

DRC1_HUMAN

Dynein regulatory complex protein 1

0.331

CFA43_HUMAN

Cilia- and flagella-associated protein 43

0.331

WDR92_HUMAN

WD repeat-containing protein 92

0.333

TT30B_HUMAN

Tetratricopeptide repeat protein 30B

0.335

IF122_HUMAN

Intraflagellar transport protein 122 homolog

0.339

IFT56_HUMAN

Intraflagellar transport protein 56

0.339

SSNA1_HUMAN

Sjoegren syndrome nuclear autoantigen 1

0.345

CCD40_HUMAN

Coiled-coil domain-containing protein 40

0.349

IFT52_HUMAN

Intraflagellar transport protein 52 homolog

0.350

TT30A_HUMAN

Tetratricopeptide repeat protein 30A

0.352

MIPT3_HUMAN

TRAF3-interacting protein 1

0.354

WDR19_HUMAN

WD repeat-containing protein 19

0.354

IF172_HUMAN

Intraflagellar transport protein 172 homolog

0.356

WDR35_HUMAN

WD repeat-containing protein 35

0.356

DRC2_HUMAN

Dynein regulatory complex subunit 2

0.364

CF251_HUMAN

Cilia- and flagella-associated protein 251

0.366

CCD42_HUMAN

Coiled-coil domain-containing protein 42

0.366

CFA44_HUMAN

Cilia- and flagella-associated protein 44

0.366

RSPH3_HUMAN

Radial spoke head protein 3 homolog

0.366

CC113_HUMAN

Coiled-coil domain-containing protein 113

0.366

CP100_HUMAN

Cilia- and flagella-associated protein 100

0.366

DRC3_HUMAN

Dynein regulatory complex subunit 3

0.367

CENPJ_HUMAN

Centromere protein J

0.367

CLUA1_HUMAN

Clusterin-associated protein 1

0.367

IFT80_HUMAN

Intraflagellar transport protein 80 homolog

0.371

CCD63_HUMAN

Coiled-coil domain-containing protein 63

0.380

CE104_HUMAN

Centrosomal protein of 104 kDa

0.382

RSH6A_HUMAN

Radial spoke head protein 6 homolog A

0.383

CFA91_HUMAN

Cilia- and flagella-associated protein 91

0.383

DRC5_HUMAN

Dynein regulatory complex subunit 5

0.383

IF140_HUMAN

Intraflagellar transport protein 140 homolog

0.384

KIFA3_HUMAN

Kinesin-associated protein 3

0.387

TC1D2_HUMAN

Tctex1 domain-containing protein 2

0.390

SPEF1_HUMAN

Sperm flagellar protein 1

0.393

CFA65_HUMAN

Cilia- and flagella-associated protein 65

0.396

KAD7_HUMAN

Adenylate kinase 7

0.396

CF299_HUMAN

Cilia- and flagella-associated protein 299

0.398

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.254

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.286

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.292

DRC11_HUMAN

Dynein regulatory complex protein 11

0.300

CCD39_HUMAN

Coiled-coil domain-containing protein 39

0.300

CFA45_HUMAN

Cilia- and flagella-associated protein 45

0.306

DNAI2_HUMAN

Dynein intermediate chain 2, axonemal

0.310

CFA52_HUMAN

Cilia- and flagella-associated protein 52

0.312

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.313

DNAI1_HUMAN

Dynein intermediate chain 1, axonemal

0.317

CFA58_HUMAN

Cilia- and flagella-associated protein 58

0.318

ENKUR_HUMAN

Enkurin

0.326

DRC1_HUMAN

Dynein regulatory complex protein 1

0.326

TILB_HUMAN

Protein tilB homolog

0.327

CFA44_HUMAN

Cilia- and flagella-associated protein 44

0.327

DRC2_HUMAN

Dynein regulatory complex subunit 2

0.331

RSH4A_HUMAN

Radial spoke head protein 4 homolog A

0.331

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.342

PACRG_HUMAN

Parkin coregulated gene protein

0.342

WDR63_HUMAN

WD repeat-containing protein 63

0.343

CFA43_HUMAN

Cilia- and flagella-associated protein 43

0.344

RSPH9_HUMAN

Radial spoke head protein 9 homolog

0.349

RSPH3_HUMAN

Radial spoke head protein 3 homolog

0.351

DAAF5_HUMAN

Dynein assembly factor 5, axonemal

0.354

CENPJ_HUMAN

Centromere protein J

0.354

DRC5_HUMAN

Dynein regulatory complex subunit 5

0.366

POC1A_HUMAN

POC1 centriolar protein homolog A

0.367

CFA91_HUMAN

Cilia- and flagella-associated protein 91

0.371

CASC1_HUMAN

Protein CASC1

0.379

CCD63_HUMAN

Coiled-coil domain-containing protein 63

0.383

CP131_HUMAN

Centrosomal protein of 131 kDa

0.384

CCD40_HUMAN

Coiled-coil domain-containing protein 40

0.387

SPAG6_HUMAN

Sperm-associated antigen 6

0.392

PIHD3_HUMAN

Protein PIH1D3

0.394

ZMY10_HUMAN

Zinc finger MYND domain-containing protein 10

0.394

CFA61_HUMAN

Cilia- and flagella-associated protein 61

0.395

DRC3_HUMAN

Dynein regulatory complex subunit 3

0.397

SPEF1_HUMAN

Sperm flagellar protein 1

0.398

CB5D1_HUMAN

Cytochrome b5 domain-containing protein 1

0.398

DNAL4_HUMAN

Dynein light chain 4, axonemal

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 82 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy