MK11_HUMAN 2019

Gene Name MK11

Description Mitogen-activated protein kinase 11

Length 364

9606

Sequence

>sp|Q15759|MK11_HUMAN Mitogen-activated protein kinase 11
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MK14_HUMAN

Mitogen-activated protein kinase 14

0.225

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

MK14_HUMAN

Mitogen-activated protein kinase 14

0.192

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.325

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.328

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.336

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.340

SURF4_HUMAN

Surfeit locus protein 4

0.346

GOLP3_HUMAN

Golgi phosphoprotein 3

0.349

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.350

VIGLN_HUMAN

Vigilin

0.350

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.351

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.353

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.353

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.356

CUL1_HUMAN

Cullin-1

0.357

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.357

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.358

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.361

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.361

DPP4_HUMAN

Dipeptidyl peptidase 4

0.363

SEPR_HUMAN

Prolyl endopeptidase FAP

0.365

MK12_HUMAN

Mitogen-activated protein kinase 12

0.372

S39A9_HUMAN

Zinc transporter ZIP9

0.373

SEPT7_HUMAN

Septin-7

0.373

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.374

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.374

PBDC1_HUMAN

Protein PBDC1

0.376

CACP_HUMAN

Carnitine O-acetyltransferase

0.376

ZNT1_HUMAN

Zinc transporter 1

0.377

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.377

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.377

H33_HUMAN

Histone H3.3

0.378

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.378

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.378

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.379

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.379

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.379

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.380

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.381

GDE_HUMAN

Glycogen debranching enzyme

0.381

RHOA_HUMAN

Transforming protein RhoA

0.381

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.381

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.384

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.384

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.385

SNX12_HUMAN

Sorting nexin-12

0.385

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.386

COR1C_HUMAN

Coronin-1C

0.386

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.387

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.387

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.387

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.388

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.388

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.388

GATA4_HUMAN

Transcription factor GATA-4

0.388

SOS1_HUMAN

Son of sevenless homolog 1

0.388

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.389

S2533_HUMAN

Solute carrier family 25 member 33

0.389

NPRL2_HUMAN

GATOR complex protein NPRL2

0.390

SNX3_HUMAN

Sorting nexin-3

0.390

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.390

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.391

HIP1_HUMAN

Huntingtin-interacting protein 1

0.392

RHOC_HUMAN

Rho-related GTP-binding protein RhoC

0.392

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.392

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.393

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.393

SRF_HUMAN

Serum response factor

0.393

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.394

S2536_HUMAN

Solute carrier family 25 member 36

0.394

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.394

ARGI2_HUMAN

Arginase-2, mitochondrial

0.394

DOP1_HUMAN

Protein dopey-1

0.395

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.395

MOT12_HUMAN

Monocarboxylate transporter 12

0.395

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.396

PB1_HUMAN

Protein polybromo-1

0.397

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.397

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.398

DYR_HUMAN

Dihydrofolate reductase

0.398

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.398

GATA6_HUMAN

Transcription factor GATA-6

0.398

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.398

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 95 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy