ERGI2_HUMAN 2019

Gene Name ERGI2

Description Endoplasmic reticulum-Golgi intermediate compartment protein 2

Length 377

9606

Sequence

>sp|Q96RQ1|ERGI2_HUMAN Endoplasmic reticulum-Golgi intermediate compartment protein 2
MRRLNRKKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVASADGLVYEPTVFDLSPQQKEWQRMLQLIQSRLQEEHSLQDVIFKSAFKSTSTALPPREDDSSQSPNACRIHGHLYVNKVAGNFHITVGKAIPHPRGHAHLAALVNHESYNFSHRIDHLSFGELVPAIINPLDGTEKIAIDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERERIINHAAGSHGVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIVGGIFSTTGMLHGIGKFIVEIICCRFRLGSYKPVNSVPFEDGHTDNHLPLLENNTH

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.308

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.340

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.342

RBNS5_HUMAN

Rabenosyn-5

0.357

GOLP3_HUMAN

Golgi phosphoprotein 3

0.376

SNX12_HUMAN

Sorting nexin-12

0.378

KMT5B_HUMAN

Histone-lysine N-methyltransferase KMT5B

0.386

SMAG1_HUMAN

Protein Smaug homolog 1

0.388

SNX3_HUMAN

Sorting nexin-3

0.389

HGS_HUMAN

Hepatocyte growth factor-regulated tyrosine kinase substrate

0.391

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.393

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.298

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.299

POMT2_HUMAN

Protein O-mannosyl-transferase 2

0.304

GOLP3_HUMAN

Golgi phosphoprotein 3

0.305

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.314

VIGLN_HUMAN

Vigilin

0.315

SURF4_HUMAN

Surfeit locus protein 4

0.318

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.318

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.319

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.319

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.322

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.324

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.330

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.331

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.331

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.331

BAT1_HUMAN

b(0,+)-type amino acid transporter 1

0.333

DPP4_HUMAN

Dipeptidyl peptidase 4

0.333

SEPT7_HUMAN

Septin-7

0.335

PBDC1_HUMAN

Protein PBDC1

0.336

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.336

SUPT3_HUMAN

Transcription initiation protein SPT3 homolog

0.340

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.340

SEPR_HUMAN

Prolyl endopeptidase FAP

0.345

CUL1_HUMAN

Cullin-1

0.348

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.348

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.349

NIF3L_HUMAN

NIF3-like protein 1

0.349

RHOA_HUMAN

Transforming protein RhoA

0.350

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.351

M3K4_HUMAN

Mitogen-activated protein kinase kinase kinase 4

0.353

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.353

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.353

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.353

NPRL2_HUMAN

GATOR complex protein NPRL2

0.353

STRP1_HUMAN

Striatin-interacting protein 1

0.354

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.354

S39A9_HUMAN

Zinc transporter ZIP9

0.354

HIP1_HUMAN

Huntingtin-interacting protein 1

0.354

ZNT1_HUMAN

Zinc transporter 1

0.355

SOS1_HUMAN

Son of sevenless homolog 1

0.355

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.356

GATA4_HUMAN

Transcription factor GATA-4

0.358

GATA5_HUMAN

Transcription factor GATA-5

0.358

DYR_HUMAN

Dihydrofolate reductase

0.358

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.359

GDE_HUMAN

Glycogen debranching enzyme

0.360

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.361

HEM1_HUMAN

5-aminolevulinate synthase, nonspecific, mitochondrial

0.361

S2536_HUMAN

Solute carrier family 25 member 36

0.361

WDR59_HUMAN

GATOR complex protein WDR59

0.362

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.363

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.364

SNX12_HUMAN

Sorting nexin-12

0.364

MOT4_HUMAN

Monocarboxylate transporter 4

0.365

GATA6_HUMAN

Transcription factor GATA-6

0.365

AADAT_HUMAN

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

0.365

SNX8_HUMAN

Sorting nexin-8

0.365

SRF_HUMAN

Serum response factor

0.367

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.367

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.368

RHOC_HUMAN

Rho-related GTP-binding protein RhoC

0.368

CEGT_HUMAN

Ceramide glucosyltransferase

0.368

KAP2_HUMAN

cAMP-dependent protein kinase type II-alpha regulatory subunit

0.369

KAP3_HUMAN

cAMP-dependent protein kinase type II-beta regulatory subunit

0.369

PB1_HUMAN

Protein polybromo-1

0.370

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.370

CACP_HUMAN

Carnitine O-acetyltransferase

0.371

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.372

SNX3_HUMAN

Sorting nexin-3

0.372

SOS2_HUMAN

Son of sevenless homolog 2

0.373

TSC2_HUMAN

Tuberin

0.374

YLAT2_HUMAN

Y+L amino acid transporter 2

0.374

ARGI2_HUMAN

Arginase-2, mitochondrial

0.375

PEX13_HUMAN

Peroxisomal membrane protein PEX13

0.375

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.377

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.377

EP15R_HUMAN

Epidermal growth factor receptor substrate 15-like 1

0.378

DHR11_HUMAN

Dehydrogenase/reductase SDR family member 11

0.378

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.379

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.379

MK14_HUMAN

Mitogen-activated protein kinase 14

0.379

S2611_HUMAN

Sodium-independent sulfate anion transporter

0.379

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.380

MOT2_HUMAN

Monocarboxylate transporter 2

0.381

S38AB_HUMAN

Putative sodium-coupled neutral amino acid transporter 11

0.381

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.382

S2533_HUMAN

Solute carrier family 25 member 33

0.382

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.382

H33_HUMAN

Histone H3.3

0.383

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.383

STAM1_HUMAN

Signal transducing adapter molecule 1

0.383

RCC1_HUMAN

Regulator of chromosome condensation

0.383

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.384

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.385

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.385

STRP2_HUMAN

Striatin-interacting protein 2

0.385

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.386

KC1G2_HUMAN

Casein kinase I isoform gamma-2

0.387

PAXI_HUMAN

Paxillin

0.387

MOT12_HUMAN

Monocarboxylate transporter 12

0.387

SIR2_HUMAN

NAD-dependent protein deacetylase sirtuin-2

0.388

SORL_HUMAN

Sortilin-related receptor

0.389

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.389

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.389

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.389

DOP1_HUMAN

Protein dopey-1

0.391

MOT13_HUMAN

Monocarboxylate transporter 13

0.391

CCHL_HUMAN

Cytochrome c-type heme lyase

0.391

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.392

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.393

DCPS_HUMAN

m7GpppX diphosphatase

0.393

K1109_HUMAN

Transmembrane protein KIAA1109

0.393

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.393

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.393

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.394

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.394

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.394

RBNS5_HUMAN

Rabenosyn-5

0.394

DOP2_HUMAN

Protein dopey-2

0.395

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.395

PLPL6_HUMAN

Neuropathy target esterase

0.396

STAM2_HUMAN

Signal transducing adapter molecule 2

0.396

DBNL_HUMAN

Drebrin-like protein

0.396

MOT10_HUMAN

Monocarboxylate transporter 10

0.397

CLAT_HUMAN

Choline O-acetyltransferase

0.397

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.397

HYAS3_HUMAN

Hyaluronan synthase 3

0.398

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.398

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.398

YLAT1_HUMAN

Y+L amino acid transporter 1

0.398

MK11_HUMAN

Mitogen-activated protein kinase 11

0.398

HYAS2_HUMAN

Hyaluronan synthase 2

0.398

RFX3_HUMAN

Transcription factor RFX3

0.399

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.399

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.399

LIPT_HUMAN

Lipoyltransferase 1, mitochondrial

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 88 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy