EXOC8_HUMAN 2019

Gene Name EXOC8

Description Exocyst complex component 8

Length 725

9606

Sequence

>sp|Q8IYI6|EXOC8_HUMAN Exocyst complex component 8
MAMAMSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRIQALAEETAQNLKRNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLTLLPAAAAAGAAAASGGEEGVGGAGGRDHLRGQAGFFSTPGGASRDGSGPGEEGKQRTLTTLLEKVEGCRHLLETPGQYLVYNGDLVEYDADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYSLDGLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEVLEDTKRALSEKRRREQEEAAAPRGPPQVTSKATNPFEDDEEEEPAVPEVEEEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPPVKELRAKVEERVRQLTEVLVFELSPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFEIDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHCQQLGDIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHRNSEEMWRRMNLMTPEALGKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEIILVAVQHVDYSLRCEQDPEKKAFIRQNASFLYETVLPVVEKRFEEGVGKPAKQLQDLRNASRLIRVNPESTTSVV

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

EXOC4_HUMAN

Exocyst complex component 4

0.358

EXOC1_HUMAN

Exocyst complex component 1

0.382

RINT1_HUMAN

RAD50-interacting protein 1

0.385

EXOC5_HUMAN

Exocyst complex component 5

0.388

EXOC6_HUMAN

Exocyst complex component 6

0.396

HGH1_HUMAN

Protein HGH1 homolog

0.397

EXOC2_HUMAN

Exocyst complex component 2

0.398

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACLY_HUMAN

ATP-citrate synthase

0.349

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.353

ACSF2_HUMAN

Acyl-CoA synthetase family member 2, mitochondrial

0.355

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.356

EXOC1_HUMAN

Exocyst complex component 1

0.364

SYF2_HUMAN

Pre-mRNA-splicing factor SYF2

0.366

DNJC3_HUMAN

DnaJ homolog subfamily C member 3

0.371

EXOC5_HUMAN

Exocyst complex component 5

0.372

HTR5B_HUMAN

HEAT repeat-containing protein 5B

0.374

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.374

UBR7_HUMAN

Putative E3 ubiquitin-protein ligase UBR7

0.375

EXOC6_HUMAN

Exocyst complex component 6

0.375

SC16A_HUMAN

Protein transport protein Sec16A

0.375

ARPC2_HUMAN

Actin-related protein 2/3 complex subunit 2

0.376

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.376

RINT1_HUMAN

RAD50-interacting protein 1

0.376

NUP93_HUMAN

Nuclear pore complex protein Nup93

0.376

NIPBL_HUMAN

Nipped-B-like protein

0.376

GPTC1_HUMAN

G patch domain-containing protein 1

0.377

PIGS_HUMAN

GPI transamidase component PIG-S

0.377

TPC10_HUMAN

Trafficking protein particle complex subunit 10

0.378

RAD1_HUMAN

Cell cycle checkpoint protein RAD1

0.378

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.379

UVRAG_HUMAN

UV radiation resistance-associated gene protein

0.379

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.380

WDR1_HUMAN

WD repeat-containing protein 1

0.382

SNF5_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

0.382

RBM39_HUMAN

RNA-binding protein 39

0.383

CHRD1_HUMAN

Cysteine and histidine-rich domain-containing protein 1

0.383

PLST_HUMAN

Plastin-3

0.384

KDM8_HUMAN

Bifunctional peptidase and arginyl-hydroxylase JMJD5

0.385

TFP11_HUMAN

Tuftelin-interacting protein 11

0.386

TTI1_HUMAN

TELO2-interacting protein 1 homolog

0.386

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.386

PLSL_HUMAN

Plastin-2

0.386

HDHD1_HUMAN

Pseudouridine-5-phosphatase

0.386

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.386

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.387

GDIR1_HUMAN

Rho GDP-dissociation inhibitor 1

0.387

SC16B_HUMAN

Protein transport protein Sec16B

0.387

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.387

TNPO3_HUMAN

Transportin-3

0.387

CTBL1_HUMAN

Beta-catenin-like protein 1

0.388

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.388

NMNA1_HUMAN

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

0.388

EXC6B_HUMAN

Exocyst complex component 6B

0.388

NCBP1_HUMAN

Nuclear cap-binding protein subunit 1

0.389

MAEA_HUMAN

E3 ubiquitin-protein transferase MAEA

0.389

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.390

BCS1_HUMAN

Mitochondrial chaperone BCS1

0.390

AAKG2_HUMAN

5-AMP-activated protein kinase subunit gamma-2

0.390

NIPA2_HUMAN

Magnesium transporter NIPA2

0.390

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.391

GCDH_HUMAN

Glutaryl-CoA dehydrogenase, mitochondrial

0.391

HMDH_HUMAN

3-hydroxy-3-methylglutaryl-coenzyme A reductase

0.391

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.391

LACB2_HUMAN

Endoribonuclease LACTB2

0.391

ARP3_HUMAN

Actin-related protein 3

0.392

PDP1_HUMAN

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

0.392

MDHM_HUMAN

Malate dehydrogenase, mitochondrial

0.392

HTR5A_HUMAN

HEAT repeat-containing protein 5A

0.392

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.392

PIGT_HUMAN

GPI transamidase component PIG-T

0.392

ATG2B_HUMAN

Autophagy-related protein 2 homolog B

0.392

ARPC3_HUMAN

Actin-related protein 2/3 complex subunit 3

0.392

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.393

WDR26_HUMAN

WD repeat-containing protein 26

0.393

CHDH_HUMAN

Choline dehydrogenase, mitochondrial

0.393

CAPZB_HUMAN

F-actin-capping protein subunit beta

0.393

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.393

RGP1_HUMAN

RAB6A-GEF complex partner protein 2

0.393

IF4E2_HUMAN

Eukaryotic translation initiation factor 4E type 2

0.394

DHB4_HUMAN

Peroxisomal multifunctional enzyme type 2

0.394

RANB9_HUMAN

Ran-binding protein 9

0.394

EIF3L_HUMAN

Eukaryotic translation initiation factor 3 subunit L

0.394

MVD1_HUMAN

Diphosphomevalonate decarboxylase

0.395

PICAL_HUMAN

Phosphatidylinositol-binding clathrin assembly protein

0.395

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.395

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.395

PGAP1_HUMAN

GPI inositol-deacylase

0.395

TMED2_HUMAN

Transmembrane emp24 domain-containing protein 2

0.396

RRN3_HUMAN

RNA polymerase I-specific transcription initiation factor RRN3

0.396

RAD17_HUMAN

Cell cycle checkpoint protein RAD17

0.396

VDAC1_HUMAN

Voltage-dependent anion-selective channel protein 1

0.396

ACO13_HUMAN

Acyl-coenzyme A thioesterase 13

0.396

DCAM_HUMAN

S-adenosylmethionine decarboxylase proenzyme

0.397

GNAO_HUMAN

Guanine nucleotide-binding protein G(o) subunit alpha

0.397

GATA_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.397

PRDX6_HUMAN

Peroxiredoxin-6

0.397

PRC1_HUMAN

Protein regulator of cytokinesis 1

0.397

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.397

AL3A2_HUMAN

Fatty aldehyde dehydrogenase

0.397

COPE_HUMAN

Coatomer subunit epsilon

0.397

C19L2_HUMAN

CWF19-like protein 2

0.397

ZW10_HUMAN

Centromere/kinetochore protein zw10 homolog

0.397

TBC15_HUMAN

TBC1 domain family member 15

0.398

STAG2_HUMAN

Cohesin subunit SA-2

0.398

BECN1_HUMAN

Beclin-1

0.398

NDUV2_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

0.398

RBBP5_HUMAN

Retinoblastoma-binding protein 5

0.398

VPS8_HUMAN

Vacuolar protein sorting-associated protein 8 homolog

0.398

MON2_HUMAN

Protein MON2 homolog

0.399

AGO3_HUMAN

Protein argonaute-3

0.399

THOC1_HUMAN

THO complex subunit 1

0.399

EXOC3_HUMAN

Exocyst complex component 3

0.399

NDUA9_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

0.399

PDS5B_HUMAN

Sister chromatid cohesion protein PDS5 homolog B

0.399

WDHD1_HUMAN

WD repeat and HMG-box DNA-binding protein 1

0.399

SYMC_HUMAN

Methionine--tRNA ligase, cytoplasmic

0.399

STAG1_HUMAN

Cohesin subunit SA-1

0.399

LICH_HUMAN

Lysosomal acid lipase/cholesteryl ester hydrolase

0.399

UMPS_HUMAN

Uridine 5-monophosphate synthase

0.400

NSRP1_HUMAN

Nuclear speckle splicing regulatory protein 1

0.400

NDUS7_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

0.400

SSU72_HUMAN

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

0.400

TIM_HUMAN

Protein timeless homolog

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 114 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy