CBPA6_HUMAN 2019

Gene Name CBPA6

Description Carboxypeptidase A6

Length 437

9606

Sequence

>sp|Q8N4T0|CBPA6_HUMAN Carboxypeptidase A6
MKCLGKRRGQAAAFLPLCWLFLKILQPGHSHLYNNRYAGDKVIRFIPKTEEEAYALKKISYQLKVDLWQPSSISYVSEGTVTDVHIPQNGSRALLAFLQEANIQYKVLIEDLQKTLEKGSSLHTQRNRRSLSGYNYEVYHSLEEIQNWMHHLNKTHSGLIHMFSIGRSYEGRSLFILKLGRRSRLKRAVWIDCGIHAREWIGPAFCQWFVKEALLTYKSDPAMRKMLNHLYFYIMPVFNVDGYHFSWTNDRFWRKTRSRNSRFRCRGVDANRNWKVKWCDEGASMHPCDDTYCGPFPESEPEVKAVANFLRKHRKHIRAYLSFHAYAQMLLYPYSYKYATIPNFRCVESAAYKAVNALQSVYGVRYRYGPASTTLYVSSGSSMDWAYKNGIPYAFAFELRDTGYFGFLLPEMLIKPTCTETMLAVKNITMHLLKKCP

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CBPB1_HUMAN

Carboxypeptidase B

0.304

CBPA1_HUMAN

Carboxypeptidase A1

0.316

CBPA2_HUMAN

Carboxypeptidase A2

0.335

CBPA4_HUMAN

Carboxypeptidase A4

0.356

CBPA3_HUMAN

Mast cell carboxypeptidase A

0.359

ETFD_HUMAN

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

0.376

CBPA5_HUMAN

Carboxypeptidase A5

0.376

GLYG_HUMAN

Glycogenin-1

0.378

MDHM_HUMAN

Malate dehydrogenase, mitochondrial

0.380

HDHD1_HUMAN

Pseudouridine-5-phosphatase

0.382

PAPS1_HUMAN

Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1

0.382

GGT1_HUMAN

Glutathione hydrolase 1 proenzyme

0.383

LIAS_HUMAN

Lipoyl synthase, mitochondrial

0.384

POLH_HUMAN

DNA polymerase eta

0.385

LICH_HUMAN

Lysosomal acid lipase/cholesteryl ester hydrolase

0.385

EXOC5_HUMAN

Exocyst complex component 5

0.385

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.386

ETFA_HUMAN

Electron transfer flavoprotein subunit alpha, mitochondrial

0.386

GGT3_HUMAN

Putative glutathione hydrolase 3 proenzyme

0.386

TNPO3_HUMAN

Transportin-3

0.387

PAPS2_HUMAN

Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2

0.387

SGPL1_HUMAN

Sphingosine-1-phosphate lyase 1

0.387

VDAC1_HUMAN

Voltage-dependent anion-selective channel protein 1

0.387

MA1B1_HUMAN

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

0.388

TM165_HUMAN

Transmembrane protein 165

0.388

PAQR2_HUMAN

Adiponectin receptor protein 2

0.389

CATA_HUMAN

Catalase

0.389

ARPC3_HUMAN

Actin-related protein 2/3 complex subunit 3

0.389

PAQR1_HUMAN

Adiponectin receptor protein 1

0.389

PDK1_HUMAN

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

0.390

ESTD_HUMAN

S-formylglutathione hydrolase

0.390

ATG9A_HUMAN

Autophagy-related protein 9A

0.390

CBSL_HUMAN

Cystathionine beta-synthase-like protein

0.390

CBS_HUMAN

Cystathionine beta-synthase

0.390

TIM44_HUMAN

Mitochondrial import inner membrane translocase subunit TIM44

0.391

BCAT1_HUMAN

Branched-chain-amino-acid aminotransferase, cytosolic

0.392

LST8_HUMAN

Target of rapamycin complex subunit LST8

0.392

KDM5A_HUMAN

Lysine-specific demethylase 5A

0.392

ODP2_HUMAN

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

0.392

NPC1_HUMAN

NPC intracellular cholesterol transporter 1

0.392

HEAT1_HUMAN

HEAT repeat-containing protein 1

0.392

PROD_HUMAN

Proline dehydrogenase 1, mitochondrial

0.392

PDK2_HUMAN

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

0.393

EFGM_HUMAN

Elongation factor G, mitochondrial

0.393

TALDO_HUMAN

Transaldolase

0.393

GATA_HUMAN

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.393

DHB4_HUMAN

Peroxisomal multifunctional enzyme type 2

0.393

GGT2_HUMAN

Inactive glutathione hydrolase 2

0.394

VPS39_HUMAN

Vam6/Vps39-like protein

0.394

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.394

ARPC2_HUMAN

Actin-related protein 2/3 complex subunit 2

0.394

CUX1_HUMAN

Homeobox protein cut-like 1

0.394

IDH3A_HUMAN

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

0.394

F263_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

0.394

BECN1_HUMAN

Beclin-1

0.394

NUP93_HUMAN

Nuclear pore complex protein Nup93

0.395

ALAT2_HUMAN

Alanine aminotransferase 2

0.395

GCH1_HUMAN

GTP cyclohydrolase 1

0.395

COX15_HUMAN

Cytochrome c oxidase assembly protein COX15 homolog

0.395

SSDH_HUMAN

Succinate-semialdehyde dehydrogenase, mitochondrial

0.395

PDK3_HUMAN

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial

0.395

LIPM_HUMAN

Lipase member M

0.396

WIPI2_HUMAN

WD repeat domain phosphoinositide-interacting protein 2

0.396

ADHX_HUMAN

Alcohol dehydrogenase class-3

0.396

CGL_HUMAN

Cystathionine gamma-lyase

0.396

PDP1_HUMAN

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

0.396

PIGT_HUMAN

GPI transamidase component PIG-T

0.396

FUMH_HUMAN

Fumarate hydratase, mitochondrial

0.396

GDIR1_HUMAN

Rho GDP-dissociation inhibitor 1

0.397

BCS1_HUMAN

Mitochondrial chaperone BCS1

0.397

PLST_HUMAN

Plastin-3

0.397

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.397

PGAP1_HUMAN

GPI inositol-deacylase

0.397

SYDM_HUMAN

Aspartate--tRNA ligase, mitochondrial

0.397

MPCP_HUMAN

Phosphate carrier protein, mitochondrial

0.398

FANCM_HUMAN

Fanconi anemia group M protein

0.398

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.398

S4A10_HUMAN

Sodium-driven chloride bicarbonate exchanger

0.398

KAT1_HUMAN

Kynurenine--oxoglutarate transaminase 1

0.398

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.398

KAT3_HUMAN

Kynurenine--oxoglutarate transaminase 3

0.398

UMPS_HUMAN

Uridine 5-monophosphate synthase

0.399

GOSR1_HUMAN

Golgi SNAP receptor complex member 1

0.399

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.399

F262_HUMAN

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

0.399

CATD_HUMAN

Cathepsin D

0.399

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.399

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.399

HIBCH_HUMAN

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

0.399

FMO5_HUMAN

Dimethylaniline monooxygenase [N-oxide-forming] 5

0.399

KIN17_HUMAN

DNA/RNA-binding protein KIN17

0.400

ATPG_HUMAN

ATP synthase subunit gamma, mitochondrial

0.400

SDHA_HUMAN

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

0.400

HMCS1_HUMAN

Hydroxymethylglutaryl-CoA synthase, cytoplasmic

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 111 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy