CBPA1_HUMAN 2019

Gene Name CBPA1

Description Carboxypeptidase A1

Length 419

9606

Sequence

>sp|P15085|CBPA1_HUMAN Carboxypeptidase A1
MRGLLVLSVLLGAVFGKEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPGSPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFGLSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

CBPB1_HUMAN

Carboxypeptidase B

0.225

CBPA4_HUMAN

Carboxypeptidase A4

0.279

CBPA2_HUMAN

Carboxypeptidase A2

0.314

CBPA3_HUMAN

Mast cell carboxypeptidase A

0.360

CBPA5_HUMAN

Carboxypeptidase A5

0.370

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CBPB1_HUMAN

Carboxypeptidase B

0.149

CBPA2_HUMAN

Carboxypeptidase A2

0.190

CBPA4_HUMAN

Carboxypeptidase A4

0.214

CBPA5_HUMAN

Carboxypeptidase A5

0.255

CBPA3_HUMAN

Mast cell carboxypeptidase A

0.263

CBPA6_HUMAN

Carboxypeptidase A6

0.316

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.341

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.355

NPRL2_HUMAN

GATOR complex protein NPRL2

0.362

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.363

VIGLN_HUMAN

Vigilin

0.364

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.368

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.369

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.371

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.372

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.372

GOLP3_HUMAN

Golgi phosphoprotein 3

0.373

DPP4_HUMAN

Dipeptidyl peptidase 4

0.373

CACP_HUMAN

Carnitine O-acetyltransferase

0.373

SOS1_HUMAN

Son of sevenless homolog 1

0.373

STRP1_HUMAN

Striatin-interacting protein 1

0.376

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.376

MPIP1_HUMAN

M-phase inducer phosphatase 1

0.377

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.381

SEPR_HUMAN

Prolyl endopeptidase FAP

0.381

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.381

S2536_HUMAN

Solute carrier family 25 member 36

0.382

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.382

SURF4_HUMAN

Surfeit locus protein 4

0.383

ARGI2_HUMAN

Arginase-2, mitochondrial

0.383

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.384

PNPO_HUMAN

Pyridoxine-5-phosphate oxidase

0.384

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.384

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.385

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.385

RCC1_HUMAN

Regulator of chromosome condensation

0.385

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.385

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.386

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.386

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.386

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.386

COR1C_HUMAN

Coronin-1C

0.387

MPIP2_HUMAN

M-phase inducer phosphatase 2

0.387

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.388

PLPL6_HUMAN

Neuropathy target esterase

0.388

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.389

MOT12_HUMAN

Monocarboxylate transporter 12

0.389

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.389

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.390

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.390

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.390

CBPB2_HUMAN

Carboxypeptidase B2

0.391

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.391

MIO_HUMAN

GATOR complex protein MIOS

0.391

SEPT7_HUMAN

Septin-7

0.392

ZNT1_HUMAN

Zinc transporter 1

0.392

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.392

SOS2_HUMAN

Son of sevenless homolog 2

0.393

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.394

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.394

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.394

HID1_HUMAN

Protein HID1

0.394

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.395

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.395

ARMT1_HUMAN

Protein-glutamate O-methyltransferase

0.395

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.396

CCHL_HUMAN

Cytochrome c-type heme lyase

0.396

GDE_HUMAN

Glycogen debranching enzyme

0.396

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.397

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.397

CC14B_HUMAN

Dual specificity protein phosphatase CDC14B

0.398

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.398

RFX2_HUMAN

DNA-binding protein RFX2

0.399

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.399

PB1_HUMAN

Protein polybromo-1

0.400

CUL1_HUMAN

Cullin-1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 96 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy