DCA11_HUMAN 2019

Gene Name DCA11

Description DDB1- and CUL4-associated factor 11

Length 546

9606

Sequence

>sp|Q8TEB1|DCA11_HUMAN DDB1- and CUL4-associated factor 11
MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQGGGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQLGLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTPFSSPQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACLY_HUMAN

ATP-citrate synthase

0.335

CHDH_HUMAN

Choline dehydrogenase, mitochondrial

0.341

PIMT_HUMAN

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

0.342

GCDH_HUMAN

Glutaryl-CoA dehydrogenase, mitochondrial

0.344

ACSF2_HUMAN

Acyl-CoA synthetase family member 2, mitochondrial

0.345

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.349

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.351

ODBA_HUMAN

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

0.351

GPTC1_HUMAN

G patch domain-containing protein 1

0.355

PCP_HUMAN

Lysosomal Pro-X carboxypeptidase

0.357

MANBA_HUMAN

Beta-mannosidase

0.359

CSN7A_HUMAN

COP9 signalosome complex subunit 7a

0.362

KDM8_HUMAN

Bifunctional peptidase and arginyl-hydroxylase JMJD5

0.363

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.364

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.366

MCCB_HUMAN

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

0.367

RBM39_HUMAN

RNA-binding protein 39

0.371

ODBB_HUMAN

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

0.372

CLPT1_HUMAN

Cleft lip and palate transmembrane protein 1

0.372

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.375

FAN1_HUMAN

Fanconi-associated nuclease 1

0.376

IVD_HUMAN

Isovaleryl-CoA dehydrogenase, mitochondrial

0.377

CSN3_HUMAN

COP9 signalosome complex subunit 3

0.379

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.380

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.381

UVRAG_HUMAN

UV radiation resistance-associated gene protein

0.381

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.383

NDUS8_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

0.383

TPC10_HUMAN

Trafficking protein particle complex subunit 10

0.383

ARL8B_HUMAN

ADP-ribosylation factor-like protein 8B

0.384

DDC_HUMAN

Aromatic-L-amino-acid decarboxylase

0.385

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.385

CC130_HUMAN

Coiled-coil domain-containing protein 130

0.385

RBM8A_HUMAN

RNA-binding protein 8A

0.386

SCPDL_HUMAN

Saccharopine dehydrogenase-like oxidoreductase

0.386

EIF3L_HUMAN

Eukaryotic translation initiation factor 3 subunit L

0.386

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.388

PPIL1_HUMAN

Peptidyl-prolyl cis-trans isomerase-like 1

0.388

GALM_HUMAN

Aldose 1-epimerase

0.388

CHRD1_HUMAN

Cysteine and histidine-rich domain-containing protein 1

0.388

CP4V2_HUMAN

Cytochrome P450 4V2

0.389

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.389

ALKB6_HUMAN

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6

0.390

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.390

MMSA_HUMAN

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

0.390

STRAP_HUMAN

Serine-threonine kinase receptor-associated protein

0.391

NDUA9_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

0.394

NSRP1_HUMAN

Nuclear speckle splicing regulatory protein 1

0.394

NDUF6_HUMAN

NADH dehydrogenase (ubiquinone) complex I, assembly factor 6

0.394

C19L2_HUMAN

CWF19-like protein 2

0.395

HEXB_HUMAN

Beta-hexosaminidase subunit beta

0.395

NDUS4_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

0.395

TSSP_HUMAN

Thymus-specific serine protease

0.396

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.396

ACO13_HUMAN

Acyl-coenzyme A thioesterase 13

0.396

NDUF5_HUMAN

Arginine-hydroxylase NDUFAF5, mitochondrial

0.397

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.397

RANB9_HUMAN

Ran-binding protein 9

0.397

RL28_HUMAN

60S ribosomal protein L28

0.398

SYF2_HUMAN

Pre-mRNA-splicing factor SYF2

0.398

GEPH_HUMAN

Gephyrin

0.398

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.399

MPU1_HUMAN

Mannose-P-dolichol utilization defect 1 protein

0.399

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.399

DNJC3_HUMAN

DnaJ homolog subfamily C member 3

0.399

MOCOS_HUMAN

Molybdenum cofactor sulfurase

0.399

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.399

THOC1_HUMAN

THO complex subunit 1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 113 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy