OTUB1_HUMAN 2019

Gene Name OTUB1

Description Ubiquitin thioesterase OTUB1

Length 271

9606

Sequence

>sp|Q96FW1|OTUB1_HUMAN Ubiquitin thioesterase OTUB1
MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLEALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLASFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHIHIIALAQALSVSIQVEYMDRGEGGTTNPHIFPEGSEPKVYLLYRPGHYDILYK

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

AT2A2_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

0.347

CSN1_HUMAN

COP9 signalosome complex subunit 1

0.350

NUDC_HUMAN

Nuclear migration protein nudC

0.351

ACLY_HUMAN

ATP-citrate synthase

0.352

PPIL2_HUMAN

RING-type E3 ubiquitin-protein ligase PPIL2

0.361

AT2A1_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

0.361

EIF3E_HUMAN

Eukaryotic translation initiation factor 3 subunit E

0.364

ODBA_HUMAN

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

0.365

MCCB_HUMAN

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

0.365

SCPDL_HUMAN

Saccharopine dehydrogenase-like oxidoreductase

0.365

EIF3L_HUMAN

Eukaryotic translation initiation factor 3 subunit L

0.366

CLPT1_HUMAN

Cleft lip and palate transmembrane protein 1

0.367

PIMT_HUMAN

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

0.368

CHRD1_HUMAN

Cysteine and histidine-rich domain-containing protein 1

0.368

EIF3D_HUMAN

Eukaryotic translation initiation factor 3 subunit D

0.368

CSN4_HUMAN

COP9 signalosome complex subunit 4

0.370

GCDH_HUMAN

Glutaryl-CoA dehydrogenase, mitochondrial

0.370

CHDH_HUMAN

Choline dehydrogenase, mitochondrial

0.373

DNJC3_HUMAN

DnaJ homolog subfamily C member 3

0.373

ACSF2_HUMAN

Acyl-CoA synthetase family member 2, mitochondrial

0.374

PPIL1_HUMAN

Peptidyl-prolyl cis-trans isomerase-like 1

0.374

RBM39_HUMAN

RNA-binding protein 39

0.374

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.374

OTUB2_HUMAN

Ubiquitin thioesterase OTUB2

0.376

PPWD1_HUMAN

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.376

KDM8_HUMAN

Bifunctional peptidase and arginyl-hydroxylase JMJD5

0.376

CATIN_HUMAN

Cactin

0.377

AT2A3_HUMAN

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

0.378

ODBB_HUMAN

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

0.378

AGO2_HUMAN

Protein argonaute-2

0.379

GPTC1_HUMAN

G patch domain-containing protein 1

0.380

COPE_HUMAN

Coatomer subunit epsilon

0.381

NDUV2_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

0.382

AGO3_HUMAN

Protein argonaute-3

0.382

AGO4_HUMAN

Protein argonaute-4

0.382

NDUA9_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

0.383

RIC1_HUMAN

RAB6A-GEF complex partner protein 1

0.383

IVD_HUMAN

Isovaleryl-CoA dehydrogenase, mitochondrial

0.383

ARL8B_HUMAN

ADP-ribosylation factor-like protein 8B

0.384

NDUV1_HUMAN

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.385

CAND1_HUMAN

Cullin-associated NEDD8-dissociated protein 1

0.385

CCD12_HUMAN

Coiled-coil domain-containing protein 12

0.385

EIF3K_HUMAN

Eukaryotic translation initiation factor 3 subunit K

0.385

CC130_HUMAN

Coiled-coil domain-containing protein 130

0.385

CSN7A_HUMAN

COP9 signalosome complex subunit 7a

0.386

RL28_HUMAN

60S ribosomal protein L28

0.386

CTBL1_HUMAN

Beta-catenin-like protein 1

0.387

EIF3M_HUMAN

Eukaryotic translation initiation factor 3 subunit M

0.388

VPS51_HUMAN

Vacuolar protein sorting-associated protein 51 homolog

0.388

SE1L1_HUMAN

Protein sel-1 homolog 1

0.388

AGO1_HUMAN

Protein argonaute-1

0.389

EMC2_HUMAN

ER membrane protein complex subunit 2

0.390

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.390

MAK_HUMAN

Serine/threonine-protein kinase MAK

0.391

GID8_HUMAN

Glucose-induced degradation protein 8 homolog

0.391

CSN3_HUMAN

COP9 signalosome complex subunit 3

0.391

NDUF5_HUMAN

Arginine-hydroxylase NDUFAF5, mitochondrial

0.391

GALM_HUMAN

Aldose 1-epimerase

0.391

U5S1_HUMAN

116 kDa U5 small nuclear ribonucleoprotein component

0.391

3HIDH_HUMAN

3-hydroxyisobutyrate dehydrogenase, mitochondrial

0.393

DDB1_HUMAN

DNA damage-binding protein 1

0.393

CSN7B_HUMAN

COP9 signalosome complex subunit 7b

0.393

ACO13_HUMAN

Acyl-coenzyme A thioesterase 13

0.393

VTA1_HUMAN

Vacuolar protein sorting-associated protein VTA1 homolog

0.393

NDUS7_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

0.394

RANB9_HUMAN

Ran-binding protein 9

0.394

C19L2_HUMAN

CWF19-like protein 2

0.394

MET16_HUMAN

RNA N6-adenosine-methyltransferase METTL16

0.396

EXOC1_HUMAN

Exocyst complex component 1

0.396

MMSA_HUMAN

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

0.396

TFP11_HUMAN

Tuftelin-interacting protein 11

0.396

DDC_HUMAN

Aromatic-L-amino-acid decarboxylase

0.396

PCP_HUMAN

Lysosomal Pro-X carboxypeptidase

0.396

IF4E2_HUMAN

Eukaryotic translation initiation factor 4E type 2

0.396

RBM8A_HUMAN

RNA-binding protein 8A

0.397

NDUS1_HUMAN

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

0.397

NDUS8_HUMAN

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

0.397

CP4V2_HUMAN

Cytochrome P450 4V2

0.397

MAEA_HUMAN

E3 ubiquitin-protein transferase MAEA

0.397

HCDH_HUMAN

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

0.397

TXNL1_HUMAN

Thioredoxin-like protein 1

0.397

MGN2_HUMAN

Protein mago nashi homolog 2

0.397

TPC10_HUMAN

Trafficking protein particle complex subunit 10

0.397

NIPA2_HUMAN

Magnesium transporter NIPA2

0.398

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.398

SND1_HUMAN

Staphylococcal nuclease domain-containing protein 1

0.398

DNJC9_HUMAN

DnaJ homolog subfamily C member 9

0.398

CD11B_HUMAN

Cyclin-dependent kinase 11B

0.399

IDE_HUMAN

Insulin-degrading enzyme

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 127 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy