PMYT1_HUMAN 2019

Gene Name PMYT1

Description Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Length 499

9606

Sequence

>sp|Q99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.345

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.348

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.358

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.361

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.361

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.362

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.365

VIGLN_HUMAN

Vigilin

0.365

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.365

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.368

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.368

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.368

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.369

S2536_HUMAN

Solute carrier family 25 member 36

0.371

SOS1_HUMAN

Son of sevenless homolog 1

0.371

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.372

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.372

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.373

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.373

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.374

S2533_HUMAN

Solute carrier family 25 member 33

0.375

COR1C_HUMAN

Coronin-1C

0.375

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.377

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.378

NPRL2_HUMAN

GATOR complex protein NPRL2

0.379

H33_HUMAN

Histone H3.3

0.379

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.379

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.380

TBC20_HUMAN

TBC1 domain family member 20

0.380

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.380

SEPT7_HUMAN

Septin-7

0.380

COR1A_HUMAN

Coronin-1A

0.381

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.381

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.383

CACP_HUMAN

Carnitine O-acetyltransferase

0.384

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.384

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.385

CCHL_HUMAN

Cytochrome c-type heme lyase

0.385

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.386

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.386

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.387

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.387

SOS2_HUMAN

Son of sevenless homolog 2

0.388

CUL1_HUMAN

Cullin-1

0.389

CORO6_HUMAN

Coronin-6

0.389

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.389

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.390

DOP1_HUMAN

Protein dopey-1

0.390

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.390

RCC1_HUMAN

Regulator of chromosome condensation

0.391

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.392

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.392

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.392

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.393

GATA2_HUMAN

Endothelial transcription factor GATA-2

0.393

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.395

GOLP3_HUMAN

Golgi phosphoprotein 3

0.395

PLPL6_HUMAN

Neuropathy target esterase

0.395

CPSF4_HUMAN

Cleavage and polyadenylation specificity factor subunit 4

0.395

COR1B_HUMAN

Coronin-1B

0.396

RDH13_HUMAN

Retinol dehydrogenase 13

0.396

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.397

SURF4_HUMAN

Surfeit locus protein 4

0.398

KYNU_HUMAN

Kynureninase

0.398

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.399

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.399

RHOA_HUMAN

Transforming protein RhoA

0.400

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.400

NUDT5_HUMAN

ADP-sugar pyrophosphatase

0.400

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 104 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy