KYNU_HUMAN 2019

Gene Name KYNU

Description Kynureninase

Length 465

9606

Sequence

>sp|Q16719|KYNU_HUMAN Kynureninase
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

3HAO_HUMAN

3-hydroxyanthranilate 3,4-dioxygenase

0.317

I23O2_HUMAN

Indoleamine 2,3-dioxygenase 2

0.322

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.341

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.352

IQGA1_HUMAN

Ras GTPase-activating-like protein IQGAP1

0.352

VIGLN_HUMAN

Vigilin

0.358

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.358

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.359

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.360

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.361

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.361

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.363

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.364

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.364

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.367

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.367

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.367

SOS1_HUMAN

Son of sevenless homolog 1

0.368

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.369

MA2C1_HUMAN

Alpha-mannosidase 2C1

0.369

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.369

GDE_HUMAN

Glycogen debranching enzyme

0.370

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.372

SURF4_HUMAN

Surfeit locus protein 4

0.374

HID1_HUMAN

Protein HID1

0.374

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.374

IMPCT_HUMAN

Protein IMPACT

0.375

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.375

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.375

LAT1_HUMAN

Large neutral amino acids transporter small subunit 1

0.375

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.376

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.377

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.377

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.378

I23O1_HUMAN

Indoleamine 2,3-dioxygenase 1

0.379

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.380

S2536_HUMAN

Solute carrier family 25 member 36

0.380

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.380

CUL1_HUMAN

Cullin-1

0.380

LMA2L_HUMAN

VIP36-like protein

0.380

CACP_HUMAN

Carnitine O-acetyltransferase

0.380

NPRL2_HUMAN

GATOR complex protein NPRL2

0.381

DOCK3_HUMAN

Dedicator of cytokinesis protein 3

0.382

SOS2_HUMAN

Son of sevenless homolog 2

0.382

GOLP3_HUMAN

Golgi phosphoprotein 3

0.383

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.383

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.383

S2533_HUMAN

Solute carrier family 25 member 33

0.384

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.384

CAN7_HUMAN

Calpain-7

0.385

OGFD1_HUMAN

Prolyl 3-hydroxylase OGFOD1

0.385

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.386

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.386

DOCK2_HUMAN

Dedicator of cytokinesis protein 2

0.387

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.388

DOCK4_HUMAN

Dedicator of cytokinesis protein 4

0.388

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.388

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.388

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.389

RDH14_HUMAN

Retinol dehydrogenase 14

0.390

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.390

MOT12_HUMAN

Monocarboxylate transporter 12

0.390

DOCK1_HUMAN

Dedicator of cytokinesis protein 1

0.390

KMO_HUMAN

Kynurenine 3-monooxygenase

0.390

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.391

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.391

NUDT5_HUMAN

ADP-sugar pyrophosphatase

0.391

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.391

STRP1_HUMAN

Striatin-interacting protein 1

0.391

DC1I2_HUMAN

Cytoplasmic dynein 1 intermediate chain 2

0.392

SEPT7_HUMAN

Septin-7

0.392

MYO1F_HUMAN

Unconventional myosin-If

0.392

ARGI2_HUMAN

Arginase-2, mitochondrial

0.392

DPP4_HUMAN

Dipeptidyl peptidase 4

0.392

GATA3_HUMAN

Trans-acting T-cell-specific transcription factor GATA-3

0.393

ZNT1_HUMAN

Zinc transporter 1

0.393

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.393

IQGA3_HUMAN

Ras GTPase-activating-like protein IQGAP3

0.393

CLAT_HUMAN

Choline O-acetyltransferase

0.394

TMLH_HUMAN

Trimethyllysine dioxygenase, mitochondrial

0.394

SEPR_HUMAN

Prolyl endopeptidase FAP

0.394

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.394

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.394

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.395

MYO1E_HUMAN

Unconventional myosin-Ie

0.395

S39A9_HUMAN

Zinc transporter ZIP9

0.395

GLP3L_HUMAN

Golgi phosphoprotein 3-like

0.395

HIP1_HUMAN

Huntingtin-interacting protein 1

0.396

PAXI_HUMAN

Paxillin

0.396

COR1C_HUMAN

Coronin-1C

0.396

CEGT_HUMAN

Ceramide glucosyltransferase

0.396

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.396

H33_HUMAN

Histone H3.3

0.396

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.397

PEMT_HUMAN

Phosphatidylethanolamine N-methyltransferase

0.397

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.397

FAAH1_HUMAN

Fatty-acid amide hydrolase 1

0.398

ENTP4_HUMAN

Ectonucleoside triphosphate diphosphohydrolase 4

0.398

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.398

PMYT1_HUMAN

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

0.398

DOP1_HUMAN

Protein dopey-1

0.399

SRF_HUMAN

Serum response factor

0.400

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.400

TGFI1_HUMAN

Transforming growth factor beta-1-induced transcript 1 protein

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 102 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy