CHM1A_HUMAN 2019

Gene Name CHM1A

Description Charged multivesicular body protein 1a

Length 196

9606

Sequence

>sp|Q9HD42|CHM1A_HUMAN Charged multivesicular body protein 1a
MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SNRPA_HUMAN

U1 small nuclear ribonucleoprotein A

0.372

VPS18_HUMAN

Vacuolar protein sorting-associated protein 18 homolog

0.377

AP1G1_HUMAN

AP-1 complex subunit gamma-1

0.378

VPS11_HUMAN

Vacuolar protein sorting-associated protein 11 homolog

0.380

SNAB_HUMAN

Beta-soluble NSF attachment protein

0.383

VPS35_HUMAN

Vacuolar protein sorting-associated protein 35

0.383

NAA15_HUMAN

N-alpha-acetyltransferase 15, NatA auxiliary subunit

0.384

TPPC3_HUMAN

Trafficking protein particle complex subunit 3

0.385

UBP14_HUMAN

Ubiquitin carboxyl-terminal hydrolase 14

0.385

STX16_HUMAN

Syntaxin-16

0.385

MARE2_HUMAN

Microtubule-associated protein RP/EB family member 2

0.385

DYL2_HUMAN

Dynein light chain 2, cytoplasmic

0.385

1433E_HUMAN

14-3-3 protein epsilon

0.386

CD123_HUMAN

Cell division cycle protein 123 homolog

0.387

PWP1_HUMAN

Periodic tryptophan protein 1 homolog

0.388

BIG1_HUMAN

Brefeldin A-inhibited guanine nucleotide-exchange protein 1

0.389

CRNL1_HUMAN

Crooked neck-like protein 1

0.390

SF3B1_HUMAN

Splicing factor 3B subunit 1

0.390

H2B1C_HUMAN

Histone H2B type 1-C/E/F/G/I

0.391

SNAA_HUMAN

Alpha-soluble NSF attachment protein

0.391

MARE1_HUMAN

Microtubule-associated protein RP/EB family member 1

0.391

SF3B3_HUMAN

Splicing factor 3B subunit 3

0.391

WDR36_HUMAN

WD repeat-containing protein 36

0.391

XPO2_HUMAN

Exportin-2

0.391

CLH1_HUMAN

Clathrin heavy chain 1

0.391

BYST_HUMAN

Bystin

0.391

DPOE1_HUMAN

DNA polymerase epsilon catalytic subunit A

0.391

SC22B_HUMAN

Vesicle-trafficking protein SEC22b

0.392

CHM2A_HUMAN

Charged multivesicular body protein 2a

0.392

UTP15_HUMAN

U3 small nucleolar RNA-associated protein 15 homolog

0.392

VPS53_HUMAN

Vacuolar protein sorting-associated protein 53 homolog

0.392

STX5_HUMAN

Syntaxin-5

0.393

PA2G4_HUMAN

Proliferation-associated protein 2G4

0.393

UBE2N_HUMAN

Ubiquitin-conjugating enzyme E2 N

0.393

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.394

COPA_HUMAN

Coatomer subunit alpha

0.395

ASF1A_HUMAN

Histone chaperone ASF1A

0.395

PSMD7_HUMAN

26S proteasome non-ATPase regulatory subunit 7

0.395

UFD1_HUMAN

Ubiquitin recognition factor in ER-associated degradation protein 1

0.395

DCA13_HUMAN

DDB1- and CUL4-associated factor 13

0.395

PSA6_HUMAN

Proteasome subunit alpha type-6

0.397

GSK3B_HUMAN

Glycogen synthase kinase-3 beta

0.397

SF3B2_HUMAN

Splicing factor 3B subunit 2

0.397

HUWE1_HUMAN

E3 ubiquitin-protein ligase HUWE1

0.397

TCPQ_HUMAN

T-complex protein 1 subunit theta

0.398

DBR1_HUMAN

Lariat debranching enzyme

0.398

PSA3_HUMAN

Proteasome subunit alpha type-3

0.398

PSA1_HUMAN

Proteasome subunit alpha type-1

0.398

MOB1B_HUMAN

MOB kinase activator 1B

0.399

TSR1_HUMAN

Pre-rRNA-processing protein TSR1 homolog

0.399

RAB7A_HUMAN

Ras-related protein Rab-7a

0.399

H2B2F_HUMAN

Histone H2B type 2-F

0.399

ZN622_HUMAN

Zinc finger protein 622

0.399

PFD3_HUMAN

Prefoldin subunit 3

0.399

H2B1D_HUMAN

Histone H2B type 1-D

0.399

H2B1K_HUMAN

Histone H2B type 1-K

0.399

RNF10_HUMAN

RING finger protein 10

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CBWD1_HUMAN

COBW domain-containing protein 1

0.342

CBWD3_HUMAN

COBW domain-containing protein 3

0.342

CBWD2_HUMAN

COBW domain-containing protein 2

0.342

CBWD5_HUMAN

COBW domain-containing protein 5

0.342

CBWD6_HUMAN

COBW domain-containing protein 6

0.348

HLTF_HUMAN

Helicase-like transcription factor

0.360

DNPEP_HUMAN

Aspartyl aminopeptidase

0.361

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.361

ERG7_HUMAN

Lanosterol synthase

0.361

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.364

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.368

FDFT_HUMAN

Squalene synthase

0.371

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.371

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.373

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.374

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.374

STXB3_HUMAN

Syntaxin-binding protein 3

0.374

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.376

CD123_HUMAN

Cell division cycle protein 123 homolog

0.378

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.379

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.381

XPOT_HUMAN

Exportin-T

0.381

ERG1_HUMAN

Squalene monooxygenase

0.383

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.383

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.383

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.385

1433E_HUMAN

14-3-3 protein epsilon

0.388

CSK22_HUMAN

Casein kinase II subunit alpha

0.390

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.390

SC5D_HUMAN

Lathosterol oxidase

0.391

RNF10_HUMAN

RING finger protein 10

0.392

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.393

RANG_HUMAN

Ran-specific GTPase-activating protein

0.394

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.394

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.394

PDCL3_HUMAN

Phosducin-like protein 3

0.395

HEM6_HUMAN

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

0.395

NADK_HUMAN

NAD kinase

0.395

VPP3_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 3

0.396

PPGB_HUMAN

Lysosomal protective protein

0.396

RM03_HUMAN

39S ribosomal protein L3, mitochondrial

0.397

UNG_HUMAN

Uracil-DNA glycosylase

0.397

AMPD1_HUMAN

AMP deaminase 1

0.398

IMA5_HUMAN

Importin subunit alpha-5

0.399

KAD2_HUMAN

Adenylate kinase 2, mitochondrial

0.399

IMA7_HUMAN

Importin subunit alpha-7

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 135 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy