VPP3_HUMAN 2019

Gene Name VPP3

Description V-type proton ATPase 116 kDa subunit a isoform 3

Length 830

9606

Sequence

>sp|Q13488|VPP3_HUMAN V-type proton ATPase 116 kDa subunit a isoform 3
MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAHRIPCRDMPPTLIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAAMANQSGWSDAFLAQHTMLTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAARAASAPSILIHFINMFLFSHSPSNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAATDD

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

TBA8_HUMAN

Tubulin alpha-8 chain

0.253

VA0D2_HUMAN

V-type proton ATPase subunit d 2

0.268

TBB3_HUMAN

Tubulin beta-3 chain

0.278

TBB6_HUMAN

Tubulin beta-6 chain

0.287

VPP2_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 2

0.291

STXB3_HUMAN

Syntaxin-binding protein 3

0.299

H31_HUMAN

Histone H3.1

0.302

TBA4A_HUMAN

Tubulin alpha-4A chain

0.315

ACTC_HUMAN

Actin, alpha cardiac muscle 1

0.319

ACTH_HUMAN

Actin, gamma-enteric smooth muscle

0.320

CSK22_HUMAN

Casein kinase II subunit alpha

0.323

AMPD1_HUMAN

AMP deaminase 1

0.325

ACTA_HUMAN

Actin, aortic smooth muscle

0.326

ACTS_HUMAN

Actin, alpha skeletal muscle

0.326

HLTF_HUMAN

Helicase-like transcription factor

0.335

CATE_HUMAN

Cathepsin E

0.340

THIK_HUMAN

3-ketoacyl-CoA thiolase, peroxisomal

0.341

LETM2_HUMAN

LETM1 domain-containing protein LETM2, mitochondrial

0.343

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

0.346

MRS2_HUMAN

Magnesium transporter MRS2 homolog, mitochondrial

0.350

EPAB2_HUMAN

Embryonic polyadenylate-binding protein 2

0.350

UB2D1_HUMAN

Ubiquitin-conjugating enzyme E2 D1

0.351

CERS4_HUMAN

Ceramide synthase 4

0.353

SC11B_HUMAN

Putative signal peptidase complex catalytic subunit SEC11B

0.353

AMPD3_HUMAN

AMP deaminase 3

0.355

RBBP7_HUMAN

Histone-binding protein RBBP7

0.356

TKTL1_HUMAN

Transketolase-like protein 1

0.356

ERG7_HUMAN

Lanosterol synthase

0.356

GTR5_HUMAN

Solute carrier family 2, facilitated glucose transporter member 5

0.357

CBWD2_HUMAN

COBW domain-containing protein 2

0.359

CBWD3_HUMAN

COBW domain-containing protein 3

0.359

CBWD1_HUMAN

COBW domain-containing protein 1

0.359

CBWD5_HUMAN

COBW domain-containing protein 5

0.359

DNPEP_HUMAN

Aspartyl aminopeptidase

0.359

CDK3_HUMAN

Cyclin-dependent kinase 3

0.359

FDFT_HUMAN

Squalene synthase

0.359

TBA1C_HUMAN

Tubulin alpha-1C chain

0.361

TBB2A_HUMAN

Tubulin beta-2A chain

0.362

CBWD6_HUMAN

COBW domain-containing protein 6

0.362

CLPB_HUMAN

Caseinolytic peptidase B protein homolog

0.362

GNAT2_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-2

0.363

IMA5_HUMAN

Importin subunit alpha-5

0.364

AP1S3_HUMAN

AP-1 complex subunit sigma-3

0.365

CERS3_HUMAN

Ceramide synthase 3

0.365

GTR9_HUMAN

Solute carrier family 2, facilitated glucose transporter member 9

0.366

CP51A_HUMAN

Lanosterol 14-alpha demethylase

0.366

DNJA2_HUMAN

DnaJ homolog subfamily A member 2

0.367

ADT4_HUMAN

ADP/ATP translocase 4

0.368

FHIT_HUMAN

Bis(5-adenosyl)-triphosphatase

0.368

HSP76_HUMAN

Heat shock 70 kDa protein 6

0.368

RL3L_HUMAN

60S ribosomal protein L3-like

0.369

NB5R2_HUMAN

NADH-cytochrome b5 reductase 2

0.370

1433E_HUMAN

14-3-3 protein epsilon

0.370

AL1A3_HUMAN

Aldehyde dehydrogenase family 1 member A3

0.370

ERD23_HUMAN

ER lumen protein-retaining receptor 3

0.371

TBB4A_HUMAN

Tubulin beta-4A chain

0.371

GNAZ_HUMAN

Guanine nucleotide-binding protein G(z) subunit alpha

0.371

SH3Y1_HUMAN

SH3 domain-containing YSC84-like protein 1

0.371

MRP2_HUMAN

Canalicular multispecific organic anion transporter 1

0.371

AK1A1_HUMAN

Aldo-keto reductase family 1 member A1

0.372

PP1B_HUMAN

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

0.374

M3K3_HUMAN

Mitogen-activated protein kinase kinase kinase 3

0.374

CDK2_HUMAN

Cyclin-dependent kinase 2

0.374

NARF_HUMAN

Nuclear prelamin A recognition factor

0.374

MSMO1_HUMAN

Methylsterol monooxygenase 1

0.375

S47A1_HUMAN

Multidrug and toxin extrusion protein 1

0.375

TBB5_HUMAN

Tubulin beta chain

0.376

IMA6_HUMAN

Importin subunit alpha-6

0.376

PP1G_HUMAN

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

0.376

GNAT1_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-1

0.377

GTR7_HUMAN

Solute carrier family 2, facilitated glucose transporter member 7

0.377

VPP4_HUMAN

V-type proton ATPase 116 kDa subunit a isoform 4

0.377

M3K2_HUMAN

Mitogen-activated protein kinase kinase kinase 2

0.377

ERG1_HUMAN

Squalene monooxygenase

0.378

IMA7_HUMAN

Importin subunit alpha-7

0.379

HS71L_HUMAN

Heat shock 70 kDa protein 1-like

0.379

GNAT3_HUMAN

Guanine nucleotide-binding protein G(t) subunit alpha-3

0.380

VP26A_HUMAN

Vacuolar protein sorting-associated protein 26A

0.380

SERC5_HUMAN

Serine incorporator 5

0.380

MAOM_HUMAN

NAD-dependent malic enzyme, mitochondrial

0.381

NSDHL_HUMAN

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.381

AL1A1_HUMAN

Retinal dehydrogenase 1

0.382

TBB8_HUMAN

Tubulin beta-8 chain

0.383

RANG_HUMAN

Ran-specific GTPase-activating protein

0.383

S47A2_HUMAN

Multidrug and toxin extrusion protein 2

0.383

GRPE2_HUMAN

GrpE protein homolog 2, mitochondrial

0.384

TMCO4_HUMAN

Transmembrane and coiled-coil domain-containing protein 4

0.385

AP1M2_HUMAN

AP-1 complex subunit mu-2

0.385

GSHR_HUMAN

Glutathione reductase, mitochondrial

0.386

VATC2_HUMAN

V-type proton ATPase subunit C 2

0.386

TRUB1_HUMAN

Probable tRNA pseudouridine synthase 1

0.387

TBB2B_HUMAN

Tubulin beta-2B chain

0.388

PP1A_HUMAN

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

0.389

OTC_HUMAN

Ornithine carbamoyltransferase, mitochondrial

0.390

TBA3C_HUMAN

Tubulin alpha-3C chain

0.391

KC1D_HUMAN

Casein kinase I isoform delta

0.391

IDHP_HUMAN

Isocitrate dehydrogenase [NADP], mitochondrial

0.392

ABCG2_HUMAN

ATP-binding cassette sub-family G member 2

0.392

TBA3D_HUMAN

Tubulin alpha-3D chain

0.394

GTR11_HUMAN

Solute carrier family 2, facilitated glucose transporter member 11

0.394

TPC3L_HUMAN

Trafficking protein particle complex subunit 3-like protein

0.395

TBA1B_HUMAN

Tubulin alpha-1B chain

0.396

CHM1A_HUMAN

Charged multivesicular body protein 1a

0.396

TBA3E_HUMAN

Tubulin alpha-3E chain

0.396

KCC4_HUMAN

Calcium/calmodulin-dependent protein kinase type IV

0.397

IF2G_HUMAN

Eukaryotic translation initiation factor 2 subunit 3

0.397

UNG_HUMAN

Uracil-DNA glycosylase

0.398

H32_HUMAN

Histone H3.2

0.398

GDIB_HUMAN

Rab GDP dissociation inhibitor beta

0.399

DNJA1_HUMAN

DnaJ homolog subfamily A member 1

0.399

NCB2L_HUMAN

Nuclear cap-binding protein subunit 2-like

0.399

SC11C_HUMAN

Signal peptidase complex catalytic subunit SEC11C

0.399

ADCK2_HUMAN

Uncharacterized aarF domain-containing protein kinase 2

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 117 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy