IFT46_HUMAN 2019

Gene Name IFT46

Description Intraflagellar transport protein 46 homolog

Length 304

9606

Sequence

>sp|Q9NQC8|IFT46_HUMAN Intraflagellar transport protein 46 homolog
MADNSSDECEEENNKEKKKTSQLTPQRGFSENEDDDDDDDDSSETDSDSDDDDEEHGAPLEGAYDPADYEHLPVSAEIKELFQYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRPDGKPDNLGLLVLDEPSTKQSDPTVLSLWLTENSKQHNITQHMKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEELLGKVSLPTAEIDCSLAEYIDMICAILDIPVYKSRIQSLHLLFSLYSEFKNSQHFKALAEGKKAFTPSSNSTSQAGDMETLTFS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TT30B_HUMAN

Tetratricopeptide repeat protein 30B

0.186

IFT52_HUMAN

Intraflagellar transport protein 52 homolog

0.213

TT30A_HUMAN

Tetratricopeptide repeat protein 30A

0.214

IFT57_HUMAN

Intraflagellar transport protein 57 homolog

0.216

CLUA1_HUMAN

Clusterin-associated protein 1

0.240

MIPT3_HUMAN

TRAF3-interacting protein 1

0.263

WDR19_HUMAN

WD repeat-containing protein 19

0.263

IFT56_HUMAN

Intraflagellar transport protein 56

0.284

PACRG_HUMAN

Parkin coregulated gene protein

0.284

IF122_HUMAN

Intraflagellar transport protein 122 homolog

0.284

IF172_HUMAN

Intraflagellar transport protein 172 homolog

0.303

IF140_HUMAN

Intraflagellar transport protein 140 homolog

0.303

WDR35_HUMAN

WD repeat-containing protein 35

0.303

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.305

EFHC1_HUMAN

EF-hand domain-containing protein 1

0.320

DRC4_HUMAN

Dynein regulatory complex subunit 4

0.320

IFT80_HUMAN

Intraflagellar transport protein 80 homolog

0.322

KIFA3_HUMAN

Kinesin-associated protein 3

0.339

TILB_HUMAN

Protein tilB homolog

0.352

TT21B_HUMAN

Tetratricopeptide repeat protein 21B

0.354

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.356

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.358

IFT88_HUMAN

Intraflagellar transport protein 88 homolog

0.368

DAAF5_HUMAN

Dynein assembly factor 5, axonemal

0.369

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.371

DRC11_HUMAN

Dynein regulatory complex protein 11

0.371

C2D2A_HUMAN

Coiled-coil and C2 domain-containing protein 2A

0.371

B9D1_HUMAN

B9 domain-containing protein 1

0.371

TC1D2_HUMAN

Tctex1 domain-containing protein 2

0.374

IFT20_HUMAN

Intraflagellar transport protein 20 homolog

0.376

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.384

CFA52_HUMAN

Cilia- and flagella-associated protein 52

0.384

DNAL1_HUMAN

Dynein light chain 1, axonemal

0.387

WDR63_HUMAN

WD repeat-containing protein 63

0.387

IFT81_HUMAN

Intraflagellar transport protein 81 homolog

0.389

CB5D1_HUMAN

Cytochrome b5 domain-containing protein 1

0.389

RSH4A_HUMAN

Radial spoke head protein 4 homolog A

0.389

CCD40_HUMAN

Coiled-coil domain-containing protein 40

0.391

ZMY10_HUMAN

Zinc finger MYND domain-containing protein 10

0.392

CE104_HUMAN

Centrosomal protein of 104 kDa

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

IFT52_HUMAN

Intraflagellar transport protein 52 homolog

0.234

IFT57_HUMAN

Intraflagellar transport protein 57 homolog

0.242

CLUA1_HUMAN

Clusterin-associated protein 1

0.255

WDR19_HUMAN

WD repeat-containing protein 19

0.255

IFT56_HUMAN

Intraflagellar transport protein 56

0.264

IF172_HUMAN

Intraflagellar transport protein 172 homolog

0.276

IF140_HUMAN

Intraflagellar transport protein 140 homolog

0.277

MIPT3_HUMAN

TRAF3-interacting protein 1

0.277

IFT88_HUMAN

Intraflagellar transport protein 88 homolog

0.287

IFT80_HUMAN

Intraflagellar transport protein 80 homolog

0.289

TT30B_HUMAN

Tetratricopeptide repeat protein 30B

0.289

IF122_HUMAN

Intraflagellar transport protein 122 homolog

0.295

TT30A_HUMAN

Tetratricopeptide repeat protein 30A

0.295

WDR35_HUMAN

WD repeat-containing protein 35

0.302

KIFA3_HUMAN

Kinesin-associated protein 3

0.302

IDLC_HUMAN

Axonemal dynein light intermediate polypeptide 1

0.323

TT21B_HUMAN

Tetratricopeptide repeat protein 21B

0.327

IFT20_HUMAN

Intraflagellar transport protein 20 homolog

0.342

PACRG_HUMAN

Parkin coregulated gene protein

0.344

DC2L1_HUMAN

Cytoplasmic dynein 2 light intermediate chain 1

0.352

C2D2A_HUMAN

Coiled-coil and C2 domain-containing protein 2A

0.357

TTC8_HUMAN

Tetratricopeptide repeat protein 8

0.377

EFHC2_HUMAN

EF-hand domain-containing family member C2

0.377

IQUB_HUMAN

IQ and ubiquitin-like domain-containing protein

0.377

IFT81_HUMAN

Intraflagellar transport protein 81 homolog

0.383

EFHC1_HUMAN

EF-hand domain-containing protein 1

0.390

BBS4_HUMAN

Bardet-Biedl syndrome 4 protein

0.396

CF206_HUMAN

Cilia- and flagella-associated protein 206

0.397

IFT74_HUMAN

Intraflagellar transport protein 74 homolog

0.397

DRC7_HUMAN

Dynein regulatory complex subunit 7

0.398

CFA57_HUMAN

Cilia- and flagella-associated protein 57

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 85 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy