PICAL_HUMAN 2019

Gene Name PICAL

Description Phosphatidylinositol-binding clathrin assembly protein

Length 652

9606

Sequence

>sp|Q13492|PICAL_HUMAN Phosphatidylinositol-binding clathrin assembly protein
MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

AP180_HUMAN

Clathrin coat assembly protein AP180

0.124

USO1_HUMAN

General vesicular transport factor p115

0.314

TBC15_HUMAN

TBC1 domain family member 15

0.342

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.342

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.344

UBP46_HUMAN

Ubiquitin carboxyl-terminal hydrolase 46

0.347

UBP12_HUMAN

Ubiquitin carboxyl-terminal hydrolase 12

0.356

WDR48_HUMAN

WD repeat-containing protein 48

0.361

TBC17_HUMAN

TBC1 domain family member 17

0.362

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.366

STAG1_HUMAN

Cohesin subunit SA-1

0.368

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.369

MIA40_HUMAN

Mitochondrial intermembrane space import and assembly protein 40

0.369

PAQR1_HUMAN

Adiponectin receptor protein 1

0.371

PI4KA_HUMAN

Phosphatidylinositol 4-kinase alpha

0.371

TIPRL_HUMAN

TIP41-like protein

0.371

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.374

NC2B_HUMAN

Protein Dr1

0.375

CNOT2_HUMAN

CCR4-NOT transcription complex subunit 2

0.378

CND3_HUMAN

Condensin complex subunit 3

0.379

STAG2_HUMAN

Cohesin subunit SA-2

0.379

UBR7_HUMAN

Putative E3 ubiquitin-protein ligase UBR7

0.379

BCS1_HUMAN

Mitochondrial chaperone BCS1

0.381

RAD21_HUMAN

Double-strand-break repair protein rad21 homolog

0.383

NOC2L_HUMAN

Nucleolar complex protein 2 homolog

0.383

RBBP5_HUMAN

Retinoblastoma-binding protein 5

0.383

RINT1_HUMAN

RAD50-interacting protein 1

0.383

TAZ_HUMAN

Tafazzin

0.385

EXOC5_HUMAN

Exocyst complex component 5

0.386

PAQR2_HUMAN

Adiponectin receptor protein 2

0.387

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.387

WDR75_HUMAN

WD repeat-containing protein 75

0.387

ALG1_HUMAN

Chitobiosyldiphosphodolichol beta-mannosyltransferase

0.388

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.388

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.389

EMC3_HUMAN

ER membrane protein complex subunit 3

0.389

ALG3_HUMAN

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

0.390

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.390

NFX1_HUMAN

Transcriptional repressor NF-X1

0.390

THADA_HUMAN

Thyroid adenoma-associated protein

0.391

STX7_HUMAN

Syntaxin-7

0.392

NOL6_HUMAN

Nucleolar protein 6

0.392

CAB39_HUMAN

Calcium-binding protein 39

0.392

CHMP5_HUMAN

Charged multivesicular body protein 5

0.392

CHMP3_HUMAN

Charged multivesicular body protein 3

0.392

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.393

STX12_HUMAN

Syntaxin-12

0.393

HTR5B_HUMAN

HEAT repeat-containing protein 5B

0.394

STK26_HUMAN

Serine/threonine-protein kinase 26

0.394

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.394

WDR12_HUMAN

Ribosome biogenesis protein WDR12

0.394

BT3L4_HUMAN

Transcription factor BTF3 homolog 4

0.395

VPS28_HUMAN

Vacuolar protein sorting-associated protein 28 homolog

0.396

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.396

CHM4B_HUMAN

Charged multivesicular body protein 4b

0.397

VTA1_HUMAN

Vacuolar protein sorting-associated protein VTA1 homolog

0.397

GNA1_HUMAN

Glucosamine 6-phosphate N-acetyltransferase

0.397

EPC2_HUMAN

Enhancer of polycomb homolog 2

0.397

SLU7_HUMAN

Pre-mRNA-splicing factor SLU7

0.397

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.397

NIPBL_HUMAN

Nipped-B-like protein

0.398

SMAP1_HUMAN

Stromal membrane-associated protein 1

0.399

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.399

TMEDA_HUMAN

Transmembrane emp24 domain-containing protein 10

0.399

HEAT1_HUMAN

HEAT repeat-containing protein 1

0.399

DDX24_HUMAN

ATP-dependent RNA helicase DDX24

0.400

BRAP_HUMAN

BRCA1-associated protein

0.400

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

AP180_HUMAN

Clathrin coat assembly protein AP180

0.124

USO1_HUMAN

General vesicular transport factor p115

0.314

TBC15_HUMAN

TBC1 domain family member 15

0.342

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.342

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.344

UBP46_HUMAN

Ubiquitin carboxyl-terminal hydrolase 46

0.347

UBP12_HUMAN

Ubiquitin carboxyl-terminal hydrolase 12

0.356

WDR48_HUMAN

WD repeat-containing protein 48

0.361

TBC17_HUMAN

TBC1 domain family member 17

0.362

CKAP5_HUMAN

Cytoskeleton-associated protein 5

0.366

STAG1_HUMAN

Cohesin subunit SA-1

0.368

XPC_HUMAN

DNA repair protein complementing XP-C cells

0.369

MIA40_HUMAN

Mitochondrial intermembrane space import and assembly protein 40

0.369

PAQR1_HUMAN

Adiponectin receptor protein 1

0.371

PI4KA_HUMAN

Phosphatidylinositol 4-kinase alpha

0.371

TIPRL_HUMAN

TIP41-like protein

0.371

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.374

NC2B_HUMAN

Protein Dr1

0.375

CNOT2_HUMAN

CCR4-NOT transcription complex subunit 2

0.378

CND3_HUMAN

Condensin complex subunit 3

0.379

STAG2_HUMAN

Cohesin subunit SA-2

0.379

UBR7_HUMAN

Putative E3 ubiquitin-protein ligase UBR7

0.379

BCS1_HUMAN

Mitochondrial chaperone BCS1

0.381

RAD21_HUMAN

Double-strand-break repair protein rad21 homolog

0.383

NOC2L_HUMAN

Nucleolar complex protein 2 homolog

0.383

RBBP5_HUMAN

Retinoblastoma-binding protein 5

0.383

RINT1_HUMAN

RAD50-interacting protein 1

0.383

TAZ_HUMAN

Tafazzin

0.385

EXOC5_HUMAN

Exocyst complex component 5

0.386

PAQR2_HUMAN

Adiponectin receptor protein 2

0.387

MCAT_HUMAN

Mitochondrial carnitine/acylcarnitine carrier protein

0.387

WDR75_HUMAN

WD repeat-containing protein 75

0.387

ALG1_HUMAN

Chitobiosyldiphosphodolichol beta-mannosyltransferase

0.388

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.388

LETM1_HUMAN

Mitochondrial proton/calcium exchanger protein

0.389

EMC3_HUMAN

ER membrane protein complex subunit 3

0.389

ALG3_HUMAN

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

0.390

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.390

NFX1_HUMAN

Transcriptional repressor NF-X1

0.390

THADA_HUMAN

Thyroid adenoma-associated protein

0.391

STX7_HUMAN

Syntaxin-7

0.392

NOL6_HUMAN

Nucleolar protein 6

0.392

CAB39_HUMAN

Calcium-binding protein 39

0.392

CHMP5_HUMAN

Charged multivesicular body protein 5

0.392

CHMP3_HUMAN

Charged multivesicular body protein 3

0.392

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.393

STX12_HUMAN

Syntaxin-12

0.393

HTR5B_HUMAN

HEAT repeat-containing protein 5B

0.394

STK26_HUMAN

Serine/threonine-protein kinase 26

0.394

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.394

WDR12_HUMAN

Ribosome biogenesis protein WDR12

0.394

BT3L4_HUMAN

Transcription factor BTF3 homolog 4

0.395

VPS28_HUMAN

Vacuolar protein sorting-associated protein 28 homolog

0.396

EIF3A_HUMAN

Eukaryotic translation initiation factor 3 subunit A

0.396

CHM4B_HUMAN

Charged multivesicular body protein 4b

0.397

VTA1_HUMAN

Vacuolar protein sorting-associated protein VTA1 homolog

0.397

GNA1_HUMAN

Glucosamine 6-phosphate N-acetyltransferase

0.397

EPC2_HUMAN

Enhancer of polycomb homolog 2

0.397

SLU7_HUMAN

Pre-mRNA-splicing factor SLU7

0.397

HSP74_HUMAN

Heat shock 70 kDa protein 4

0.397

NIPBL_HUMAN

Nipped-B-like protein

0.398

SMAP1_HUMAN

Stromal membrane-associated protein 1

0.399

UGGG1_HUMAN

UDP-glucose:glycoprotein glucosyltransferase 1

0.399

TMEDA_HUMAN

Transmembrane emp24 domain-containing protein 10

0.399

HEAT1_HUMAN

HEAT repeat-containing protein 1

0.399

DDX24_HUMAN

ATP-dependent RNA helicase DDX24

0.400

BRAP_HUMAN

BRCA1-associated protein

0.400

ERGI3_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 3

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 131 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy