UBR7_HUMAN 2019

Gene Name UBR7

Description Putative E3 ubiquitin-protein ligase UBR7

Length 425

9606

Sequence

>sp|Q8N806|UBR7_HUMAN Putative E3 ubiquitin-protein ligase UBR7
MAGAEGAAGRQSELEPVVSLVDVLEEDEELENEACAVLGGSDSEKCSYSQGSVKRQALYACSTCTPEGEEPAGICLACSYECHGSHKLFELYTKRNFRCDCGNSKFKNLECKLLPDKAKVNSGNKYNDNFFGLYCICKRPYPDPEDEIPDEMIQCVVCEDWFHGRHLGAIPPESGDFQEMVCQACMKRCSFLWAYAAQLAVTKISTEDDGLVRNIDGIGDQEVIKPENGEHQDSTLKEDVPEQGKDDVREVKVEQNSEPCAGSSSESDLQTVFKNESLNAESKSGCKLQELKAKQLIKKDTATYWPLNWRSKLCTCQDCMKMYGDLDVLFLTDEYDTVLAYENKGKIAQATDRSDPLMDTLSSMNRVQQVELICEYNDLKTELKDYLKRFADEGTVVKREDIQQFFEEFQSKKRRRVDGMQYYCS

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

RINT1_HUMAN

RAD50-interacting protein 1

0.327

PLST_HUMAN

Plastin-3

0.348

NUP93_HUMAN

Nuclear pore complex protein Nup93

0.350

PLSL_HUMAN

Plastin-2

0.350

EXOC5_HUMAN

Exocyst complex component 5

0.352

SNF5_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

0.354

EXOC6_HUMAN

Exocyst complex component 6

0.361

PDPK1_HUMAN

3-phosphoinositide-dependent protein kinase 1

0.367

SYF2_HUMAN

Pre-mRNA-splicing factor SYF2

0.371

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.372

VPS36_HUMAN

Vacuolar protein-sorting-associated protein 36

0.373

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.374

TIPRL_HUMAN

TIP41-like protein

0.374

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.375

STX7_HUMAN

Syntaxin-7

0.377

NOP14_HUMAN

Nucleolar protein 14

0.377

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.377

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.379

HTR5B_HUMAN

HEAT repeat-containing protein 5B

0.379

PICAL_HUMAN

Phosphatidylinositol-binding clathrin assembly protein

0.379

EXOC4_HUMAN

Exocyst complex component 4

0.379

RAD1_HUMAN

Cell cycle checkpoint protein RAD1

0.382

EXOC1_HUMAN

Exocyst complex component 1

0.383

NUP54_HUMAN

Nucleoporin p54

0.383

DAD1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

0.385

PRC1_HUMAN

Protein regulator of cytokinesis 1

0.385

NU107_HUMAN

Nuclear pore complex protein Nup107

0.386

RBM27_HUMAN

RNA-binding protein 27

0.386

EXC6B_HUMAN

Exocyst complex component 6B

0.387

ELP2_HUMAN

Elongator complex protein 2

0.390

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.390

PP6R3_HUMAN

Serine/threonine-protein phosphatase 6 regulatory subunit 3

0.390

AP3D1_HUMAN

AP-3 complex subunit delta-1

0.391

USO1_HUMAN

General vesicular transport factor p115

0.391

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.391

GDIR1_HUMAN

Rho GDP-dissociation inhibitor 1

0.392

ELP1_HUMAN

Elongator complex protein 1

0.392

OST48_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

0.392

TAF2_HUMAN

Transcription initiation factor TFIID subunit 2

0.392

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.393

NDUA8_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

0.393

UBP12_HUMAN

Ubiquitin carboxyl-terminal hydrolase 12

0.394

PIGT_HUMAN

GPI transamidase component PIG-T

0.395

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.396

PLSI_HUMAN

Plastin-1

0.396

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.397

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.397

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.397

EIF3H_HUMAN

Eukaryotic translation initiation factor 3 subunit H

0.397

VPS54_HUMAN

Vacuolar protein sorting-associated protein 54

0.397

STK26_HUMAN

Serine/threonine-protein kinase 26

0.397

AP180_HUMAN

Clathrin coat assembly protein AP180

0.398

ORC4_HUMAN

Origin recognition complex subunit 4

0.398

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.398

STAG2_HUMAN

Cohesin subunit SA-2

0.398

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.398

ING4_HUMAN

Inhibitor of growth protein 4

0.398

CND3_HUMAN

Condensin complex subunit 3

0.398

RWDD1_HUMAN

RWD domain-containing protein 1

0.398

VDAC1_HUMAN

Voltage-dependent anion-selective channel protein 1

0.399

MEF2C_HUMAN

Myocyte-specific enhancer factor 2C

0.399

ARPC3_HUMAN

Actin-related protein 2/3 complex subunit 3

0.400

EPC2_HUMAN

Enhancer of polycomb homolog 2

0.400

PPME1_HUMAN

Protein phosphatase methylesterase 1

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

RINT1_HUMAN

RAD50-interacting protein 1

0.327

PLST_HUMAN

Plastin-3

0.348

NUP93_HUMAN

Nuclear pore complex protein Nup93

0.350

PLSL_HUMAN

Plastin-2

0.350

EXOC5_HUMAN

Exocyst complex component 5

0.352

SNF5_HUMAN

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

0.354

EXOC6_HUMAN

Exocyst complex component 6

0.361

PDPK1_HUMAN

3-phosphoinositide-dependent protein kinase 1

0.367

SYF2_HUMAN

Pre-mRNA-splicing factor SYF2

0.371

VDAC2_HUMAN

Voltage-dependent anion-selective channel protein 2

0.372

VPS36_HUMAN

Vacuolar protein-sorting-associated protein 36

0.373

RPN1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

0.374

TIPRL_HUMAN

TIP41-like protein

0.374

MIRO1_HUMAN

Mitochondrial Rho GTPase 1

0.375

STX7_HUMAN

Syntaxin-7

0.377

NOP14_HUMAN

Nucleolar protein 14

0.377

MO4L1_HUMAN

Mortality factor 4-like protein 1

0.377

PPT1_HUMAN

Palmitoyl-protein thioesterase 1

0.379

HTR5B_HUMAN

HEAT repeat-containing protein 5B

0.379

PICAL_HUMAN

Phosphatidylinositol-binding clathrin assembly protein

0.379

EXOC4_HUMAN

Exocyst complex component 4

0.379

RAD1_HUMAN

Cell cycle checkpoint protein RAD1

0.382

EXOC1_HUMAN

Exocyst complex component 1

0.383

NUP54_HUMAN

Nucleoporin p54

0.383

DAD1_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

0.385

PRC1_HUMAN

Protein regulator of cytokinesis 1

0.385

NU107_HUMAN

Nuclear pore complex protein Nup107

0.386

RBM27_HUMAN

RNA-binding protein 27

0.386

EXC6B_HUMAN

Exocyst complex component 6B

0.387

ELP2_HUMAN

Elongator complex protein 2

0.390

EIF3F_HUMAN

Eukaryotic translation initiation factor 3 subunit F

0.390

PP6R3_HUMAN

Serine/threonine-protein phosphatase 6 regulatory subunit 3

0.390

AP3D1_HUMAN

AP-3 complex subunit delta-1

0.391

USO1_HUMAN

General vesicular transport factor p115

0.391

EPC1_HUMAN

Enhancer of polycomb homolog 1

0.391

GDIR1_HUMAN

Rho GDP-dissociation inhibitor 1

0.392

ELP1_HUMAN

Elongator complex protein 1

0.392

OST48_HUMAN

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

0.392

TAF2_HUMAN

Transcription initiation factor TFIID subunit 2

0.392

ULA1_HUMAN

NEDD8-activating enzyme E1 regulatory subunit

0.393

NDUA8_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

0.393

UBP12_HUMAN

Ubiquitin carboxyl-terminal hydrolase 12

0.394

PIGT_HUMAN

GPI transamidase component PIG-T

0.395

VPS41_HUMAN

Vacuolar protein sorting-associated protein 41 homolog

0.396

PLSI_HUMAN

Plastin-1

0.396

MARH6_HUMAN

E3 ubiquitin-protein ligase MARCH6

0.397

COG6_HUMAN

Conserved oligomeric Golgi complex subunit 6

0.397

TAM41_HUMAN

Phosphatidate cytidylyltransferase, mitochondrial

0.397

EIF3H_HUMAN

Eukaryotic translation initiation factor 3 subunit H

0.397

VPS54_HUMAN

Vacuolar protein sorting-associated protein 54

0.397

STK26_HUMAN

Serine/threonine-protein kinase 26

0.397

AP180_HUMAN

Clathrin coat assembly protein AP180

0.398

ORC4_HUMAN

Origin recognition complex subunit 4

0.398

ALG9_HUMAN

Alpha-1,2-mannosyltransferase ALG9

0.398

STAG2_HUMAN

Cohesin subunit SA-2

0.398

CSN2_HUMAN

COP9 signalosome complex subunit 2

0.398

ING4_HUMAN

Inhibitor of growth protein 4

0.398

CND3_HUMAN

Condensin complex subunit 3

0.398

RWDD1_HUMAN

RWD domain-containing protein 1

0.398

VDAC1_HUMAN

Voltage-dependent anion-selective channel protein 1

0.399

MEF2C_HUMAN

Myocyte-specific enhancer factor 2C

0.399

ARPC3_HUMAN

Actin-related protein 2/3 complex subunit 3

0.400

EPC2_HUMAN

Enhancer of polycomb homolog 2

0.400

PPME1_HUMAN

Protein phosphatase methylesterase 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 127 organisms (of 369)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy