Welcome to the OrthoInspector website


Search by identifier

Select the domain of life you wish to query and search a protein by its Uniprot identifier or access.

Search by sequence similarity

Search your sequence in OrthoInspector databases using BLASTP


Search by phylogenetic profile

Find all proteins from a given species present in a selection of clades and absent in other clades.

Profile search

GO term profiles

Show the distribution of all proteins from a given species associated to a GO term.

GO profile


Domain databases

OrthoInspector dataset is divided into three domain specific databases, one for each of the three domains of cellular life. Each of these databases contains all intra-domain orthologs and inparalogs relationships inferred by OrthoInspector and can be specifically queried using the drop down menu next to the search bar.

Cross-domain database

The cross-domain database contains orthology relationships between model species of the three Life domains. These model species have been selected to include well-studied organisms and to ensure a good taxonomic sampling. These inter-domain relationships are available on protein pages of model species.

Eukaryota database

930 species

163 model species

Bacteria database

4132 species

168 model species

Archaea database

185 species

39 model species

Cross-domain database

Species from the three domains

370 model species

Further information about database content is provided in the Databases section or by clicking on the database icons above.

How to cite

If OrthoInspector has been useful to you, consider citing:

OrthoInspector 3.0: open portal for comparative genomics.
Nevers Y, Kress A, Defosset A, Ripp R, Linard B, Thompson JD, Poch O, Lecompte O.
Nucleic Acids Research. 2018 Oct 31; epub ahead of print 10.1093/nar/gky1068 .

OrthoInspector 2.0: Software and database updates.
Linard B, Allot A, Schneider R, Morel C, Ripp R, Bigler M, Thompson JD, Poch O, Lecompte O.
Bioinformatics. 2015 Feb 1;31(3):447-8. 10.1093/bioinformatics/btu642.

OrthoInspector: comprehensive orthology analysis and visual exploration.
Linard B, Thompson JD, Poch O, Lecompte O.
BMC Bioinformatics. 2011 Jan 10;12:11. 10.1186/1471-2105-12-11.