DC1I1_HUMAN 2019

Gene Name DC1I1

Description Cytoplasmic dynein 1 intermediate chain 1

Length 645

9606

Sequence

>sp|O14576|DC1I1_HUMAN Cytoplasmic dynein 1 intermediate chain 1
MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGTVELSA

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DC1I2_HUMAN

Cytoplasmic dynein 1 intermediate chain 2

0.266

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.391

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DC1I2_HUMAN

Cytoplasmic dynein 1 intermediate chain 2

0.232

DCTN4_HUMAN

Dynactin subunit 4

0.314

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.324

HID1_HUMAN

Protein HID1

0.325

DC1L2_HUMAN

Cytoplasmic dynein 1 light intermediate chain 2

0.329

ACTZ_HUMAN

Alpha-centractin

0.330

ACTN1_HUMAN

Alpha-actinin-1

0.334

PHOCN_HUMAN

MOB-like protein phocein

0.335

ECHM_HUMAN

Enoyl-CoA hydratase, mitochondrial

0.339

ACTY_HUMAN

Beta-centractin

0.340

ACTN2_HUMAN

Alpha-actinin-2

0.340

DCTN1_HUMAN

Dynactin subunit 1

0.341

DC1L1_HUMAN

Cytoplasmic dynein 1 light intermediate chain 1

0.342

LMA2L_HUMAN

VIP36-like protein

0.343

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.343

STRN_HUMAN

Striatin

0.344

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.344

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.349

SPTB2_HUMAN

Spectrin beta chain, non-erythrocytic 1

0.349

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.350

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.351

COR1C_HUMAN

Coronin-1C

0.352

STRN3_HUMAN

Striatin-3

0.352

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.353

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.353

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.353

SOS1_HUMAN

Son of sevenless homolog 1

0.354

NPRL2_HUMAN

GATOR complex protein NPRL2

0.355

SOS2_HUMAN

Son of sevenless homolog 2

0.355

STRP1_HUMAN

Striatin-interacting protein 1

0.356

ACTN3_HUMAN

Alpha-actinin-3

0.357

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.358

TSC2_HUMAN

Tuberin

0.359

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.360

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.362

CHLE_HUMAN

Cholinesterase

0.362

KMT5B_HUMAN

Histone-lysine N-methyltransferase KMT5B

0.364

ACES_HUMAN

Acetylcholinesterase

0.365

ACTN4_HUMAN

Alpha-actinin-4

0.365

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.365

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.366

CORO6_HUMAN

Coronin-6

0.366

VIGLN_HUMAN

Vigilin

0.367

PAXI_HUMAN

Paxillin

0.367

GTPB1_HUMAN

GTP-binding protein 1

0.367

STRP2_HUMAN

Striatin-interacting protein 2

0.367

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.369

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.370

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.370

COR1B_HUMAN

Coronin-1B

0.370

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.371

ACDSB_HUMAN

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

0.372

STRN4_HUMAN

Striatin-4

0.372

CUL1_HUMAN

Cullin-1

0.373

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.373

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.373

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.373

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.375

S2536_HUMAN

Solute carrier family 25 member 36

0.375

S2533_HUMAN

Solute carrier family 25 member 33

0.377

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.377

NDEL1_HUMAN

Nuclear distribution protein nudE-like 1

0.377

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.378

LPP60_HUMAN

60 kDa lysophospholipase

0.378

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.380

SPTN2_HUMAN

Spectrin beta chain, non-erythrocytic 2

0.380

GDE_HUMAN

Glycogen debranching enzyme

0.381

NDE1_HUMAN

Nuclear distribution protein nudE homolog 1

0.381

DCTN5_HUMAN

Dynactin subunit 5

0.382

PKRI1_HUMAN

PRKR-interacting protein 1

0.382

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.383

COR1A_HUMAN

Coronin-1A

0.383

CAN7_HUMAN

Calpain-7

0.384

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.384

RCC1_HUMAN

Regulator of chromosome condensation

0.384

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.384

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.385

CCHL_HUMAN

Cytochrome c-type heme lyase

0.386

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.387

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.388

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.388

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.389

KIF5C_HUMAN

Kinesin heavy chain isoform 5C

0.389

H33_HUMAN

Histone H3.3

0.389

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.389

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.390

MIO_HUMAN

GATOR complex protein MIOS

0.391

HIP1_HUMAN

Huntingtin-interacting protein 1

0.391

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.391

DOP1_HUMAN

Protein dopey-1

0.391

SEPR_HUMAN

Prolyl endopeptidase FAP

0.392

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.392

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.393

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.394

CACP_HUMAN

Carnitine O-acetyltransferase

0.394

DPP4_HUMAN

Dipeptidyl peptidase 4

0.394

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.395

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.395

ATP9B_HUMAN

Probable phospholipid-transporting ATPase IIB

0.395

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.395

DOP2_HUMAN

Protein dopey-2

0.395

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.396

TBC20_HUMAN

TBC1 domain family member 20

0.396

GOLP3_HUMAN

Golgi phosphoprotein 3

0.396

S35F6_HUMAN

Solute carrier family 35 member F6

0.396

SNX12_HUMAN

Sorting nexin-12

0.397

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.398

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.398

SNX3_HUMAN

Sorting nexin-3

0.398

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.399

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.399

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.399

KDM4C_HUMAN

Lysine-specific demethylase 4C

0.399

SURF4_HUMAN

Surfeit locus protein 4

0.400

ARGI2_HUMAN

Arginase-2, mitochondrial

0.400

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.400

SPTB1_HUMAN

Spectrin beta chain, erythrocytic

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 106 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy