DCTN4_HUMAN 2019

Gene Name DCTN4

Description Dynactin subunit 4

Length 460

9606

Sequence

>sp|Q9UJW0|DCTN4_HUMAN Dynactin subunit 4
MASLLQSDRVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSDKYGLGTRLQRPRAGASISTLAGLSLKEGEDQKEIKIEPAQAVDEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVELSLGPLLP

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

ACTZ_HUMAN

Alpha-centractin

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

DC1I2_HUMAN

Cytoplasmic dynein 1 intermediate chain 2

0.301

DC1I1_HUMAN

Cytoplasmic dynein 1 intermediate chain 1

0.314

ACTZ_HUMAN

Alpha-centractin

0.333

ACTY_HUMAN

Beta-centractin

0.339

HID1_HUMAN

Protein HID1

0.342

SOS1_HUMAN

Son of sevenless homolog 1

0.346

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.348

STRP1_HUMAN

Striatin-interacting protein 1

0.348

PHOCN_HUMAN

MOB-like protein phocein

0.353

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.353

DC1L2_HUMAN

Cytoplasmic dynein 1 light intermediate chain 2

0.354

SOS2_HUMAN

Son of sevenless homolog 2

0.355

DCTN1_HUMAN

Dynactin subunit 1

0.355

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.356

NPRL2_HUMAN

GATOR complex protein NPRL2

0.358

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.358

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.360

STRN_HUMAN

Striatin

0.361

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.362

LMA2L_HUMAN

VIP36-like protein

0.362

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.365

SPTB2_HUMAN

Spectrin beta chain, non-erythrocytic 1

0.366

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.366

ACTN2_HUMAN

Alpha-actinin-2

0.367

ACTN1_HUMAN

Alpha-actinin-1

0.368

ECHM_HUMAN

Enoyl-CoA hydratase, mitochondrial

0.369

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.369

VIGLN_HUMAN

Vigilin

0.369

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.371

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.372

STRN3_HUMAN

Striatin-3

0.372

CUL1_HUMAN

Cullin-1

0.372

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.372

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.374

STRP2_HUMAN

Striatin-interacting protein 2

0.374

GDE_HUMAN

Glycogen debranching enzyme

0.374

TSC2_HUMAN

Tuberin

0.375

CHLE_HUMAN

Cholinesterase

0.375

ACES_HUMAN

Acetylcholinesterase

0.375

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.375

S2536_HUMAN

Solute carrier family 25 member 36

0.375

PAXI_HUMAN

Paxillin

0.376

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.377

COR1C_HUMAN

Coronin-1C

0.377

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.379

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.379

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.379

QPCT_HUMAN

Glutaminyl-peptide cyclotransferase

0.379

DC1L1_HUMAN

Cytoplasmic dynein 1 light intermediate chain 1

0.379

NDEL1_HUMAN

Nuclear distribution protein nudE-like 1

0.380

RCC1_HUMAN

Regulator of chromosome condensation

0.381

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.381

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.382

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.383

KMT5B_HUMAN

Histone-lysine N-methyltransferase KMT5B

0.384

NDE1_HUMAN

Nuclear distribution protein nudE homolog 1

0.384

DPP4_HUMAN

Dipeptidyl peptidase 4

0.385

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.386

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.387

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.387

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.387

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.387

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.387

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.388

S2533_HUMAN

Solute carrier family 25 member 33

0.389

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.390

GOLP3_HUMAN

Golgi phosphoprotein 3

0.390

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.391

DCTN5_HUMAN

Dynactin subunit 5

0.391

CACP_HUMAN

Carnitine O-acetyltransferase

0.391

PKRI1_HUMAN

PRKR-interacting protein 1

0.391

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.392

GTPB1_HUMAN

GTP-binding protein 1

0.392

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.392

SUCHY_HUMAN

Succinate--hydroxymethylglutarate CoA-transferase

0.392

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.392

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.393

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.393

MIO_HUMAN

GATOR complex protein MIOS

0.393

CEGT_HUMAN

Ceramide glucosyltransferase

0.394

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.395

SNX3_HUMAN

Sorting nexin-3

0.395

CCHL_HUMAN

Cytochrome c-type heme lyase

0.395

SEPR_HUMAN

Prolyl endopeptidase FAP

0.395

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.395

CAN7_HUMAN

Calpain-7

0.395

ACTN3_HUMAN

Alpha-actinin-3

0.396

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.396

SNX12_HUMAN

Sorting nexin-12

0.396

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.396

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.396

ACTN4_HUMAN

Alpha-actinin-4

0.397

SURF4_HUMAN

Surfeit locus protein 4

0.397

ACDSB_HUMAN

Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

0.397

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.397

STRN4_HUMAN

Striatin-4

0.398

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.398

DIC_HUMAN

Mitochondrial dicarboxylate carrier

0.398

KINH_HUMAN

Kinesin-1 heavy chain

0.398

TBC20_HUMAN

TBC1 domain family member 20

0.399

KDM4A_HUMAN

Lysine-specific demethylase 4A

0.399

S35F6_HUMAN

Solute carrier family 35 member F6

0.399

LPP60_HUMAN

60 kDa lysophospholipase

0.399

HIP1_HUMAN

Huntingtin-interacting protein 1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 100 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy