CAN7_HUMAN 2019

Gene Name CAN7

Description Calpain-7

Length 813

9606

Sequence

>sp|Q9Y6W3|CAN7_HUMAN Calpain-7
MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEYLERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLGANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMPFCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNPGLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFHIEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

No protein with similar profile across the domains were found

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

COR1C_HUMAN

Coronin-1C

0.335

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.339

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.339

LMA2L_HUMAN

VIP36-like protein

0.340

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.341

DIC_HUMAN

Mitochondrial dicarboxylate carrier

0.341

HID1_HUMAN

Protein HID1

0.343

DC1I2_HUMAN

Cytoplasmic dynein 1 intermediate chain 2

0.343

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.344

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.345

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.350

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.350

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.351

NPRL2_HUMAN

GATOR complex protein NPRL2

0.352

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.354

VIGLN_HUMAN

Vigilin

0.354

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.355

CACP_HUMAN

Carnitine O-acetyltransferase

0.357

ARGI2_HUMAN

Arginase-2, mitochondrial

0.357

SOS1_HUMAN

Son of sevenless homolog 1

0.357

RCC1_HUMAN

Regulator of chromosome condensation

0.357

CORO6_HUMAN

Coronin-6

0.363

CUL1_HUMAN

Cullin-1

0.364

CLAT_HUMAN

Choline O-acetyltransferase

0.364

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.364

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.365

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.366

SYYC_HUMAN

Tyrosine--tRNA ligase, cytoplasmic

0.368

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.369

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.369

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.369

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.369

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.370

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.371

GORS2_HUMAN

Golgi reassembly-stacking protein 2

0.371

CCHL_HUMAN

Cytochrome c-type heme lyase

0.372

GGPPS_HUMAN

Geranylgeranyl pyrophosphate synthase

0.372

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.373

RABX5_HUMAN

Rab5 GDP/GTP exchange factor

0.373

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.374

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.374

S2533_HUMAN

Solute carrier family 25 member 33

0.374

SYCC_HUMAN

Cysteine--tRNA ligase, cytoplasmic

0.374

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.375

S2536_HUMAN

Solute carrier family 25 member 36

0.376

TBC20_HUMAN

TBC1 domain family member 20

0.376

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.376

COR2B_HUMAN

Coronin-2B

0.376

ARMT1_HUMAN

Protein-glutamate O-methyltransferase

0.377

COR1B_HUMAN

Coronin-1B

0.377

SOS2_HUMAN

Son of sevenless homolog 2

0.378

STRP1_HUMAN

Striatin-interacting protein 1

0.378

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.379

S35F6_HUMAN

Solute carrier family 35 member F6

0.379

PAN2_HUMAN

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

0.379

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.379

COR1A_HUMAN

Coronin-1A

0.380

RDHE2_HUMAN

Epidermal retinol dehydrogenase 2

0.381

H33_HUMAN

Histone H3.3

0.381

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.382

DC1I1_HUMAN

Cytoplasmic dynein 1 intermediate chain 1

0.384

KYNU_HUMAN

Kynureninase

0.385

ARGI1_HUMAN

Arginase-1

0.385

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.386

RMND1_HUMAN

Required for meiotic nuclear division protein 1 homolog

0.387

COR2A_HUMAN

Coronin-2A

0.387

GDE_HUMAN

Glycogen debranching enzyme

0.387

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.387

GOLP3_HUMAN

Golgi phosphoprotein 3

0.387

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.388

RRAGB_HUMAN

Ras-related GTP-binding protein B

0.388

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.388

SPTB2_HUMAN

Spectrin beta chain, non-erythrocytic 1

0.388

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.388

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.390

PYC_HUMAN

Pyruvate carboxylase, mitochondrial

0.390

MIO_HUMAN

GATOR complex protein MIOS

0.391

PLPL6_HUMAN

Neuropathy target esterase

0.391

DCPS_HUMAN

m7GpppX diphosphatase

0.391

SURF4_HUMAN

Surfeit locus protein 4

0.391

YLAT2_HUMAN

Y+L amino acid transporter 2

0.391

DPP4_HUMAN

Dipeptidyl peptidase 4

0.391

TMED9_HUMAN

Transmembrane emp24 domain-containing protein 9

0.391

DOP1_HUMAN

Protein dopey-1

0.392

TSC2_HUMAN

Tuberin

0.393

CC14A_HUMAN

Dual specificity protein phosphatase CDC14A

0.394

TMED4_HUMAN

Transmembrane emp24 domain-containing protein 4

0.394

MOT12_HUMAN

Monocarboxylate transporter 12

0.395

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.395

MYEF2_HUMAN

Myelin expression factor 2

0.395

DCTN4_HUMAN

Dynactin subunit 4

0.395

MTAP_HUMAN

S-methyl-5-thioadenosine phosphorylase

0.396

STAM1_HUMAN

Signal transducing adapter molecule 1

0.396

S39A9_HUMAN

Zinc transporter ZIP9

0.397

MYO1E_HUMAN

Unconventional myosin-Ie

0.397

PLPL7_HUMAN

Patatin-like phospholipase domain-containing protein 7

0.397

NSMA_HUMAN

Sphingomyelin phosphodiesterase 2

0.397

SEPR_HUMAN

Prolyl endopeptidase FAP

0.398

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.398

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.399

ECHM_HUMAN

Enoyl-CoA hydratase, mitochondrial

0.399

KDM4A_HUMAN

Lysine-specific demethylase 4A

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 108 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy