HGS_HUMAN 2019

Gene Name HGS

Description Hepatocyte growth factor-regulated tyrosine kinase substrate

Length 777

9606

Sequence

>sp|O14964|HGS_HUMAN Hepatocyte growth factor-regulated tyrosine kinase substrate
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD

Domains

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Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

SNX12_HUMAN

Sorting nexin-12

0.303

SNX3_HUMAN

Sorting nexin-3

0.346

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.348

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.352

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.376

STRP1_HUMAN

Striatin-interacting protein 1

0.380

STAM1_HUMAN

Signal transducing adapter molecule 1

0.385

ERGI2_HUMAN

Endoplasmic reticulum-Golgi intermediate compartment protein 2

0.391

KMT5B_HUMAN

Histone-lysine N-methyltransferase KMT5B

0.393

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.400

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

VIGLN_HUMAN

Vigilin

0.336

SOS1_HUMAN

Son of sevenless homolog 1

0.336

GOLP3_HUMAN

Golgi phosphoprotein 3

0.338

SLMAP_HUMAN

Sarcolemmal membrane-associated protein

0.339

SURF4_HUMAN

Surfeit locus protein 4

0.346

CLCN3_HUMAN

H(+)/Cl(-) exchange transporter 3

0.346

TOM70_HUMAN

Mitochondrial import receptor subunit TOM70

0.347

NPRL2_HUMAN

GATOR complex protein NPRL2

0.348

STRP1_HUMAN

Striatin-interacting protein 1

0.349

CLCN4_HUMAN

H(+)/Cl(-) exchange transporter 4

0.350

DEPD5_HUMAN

GATOR complex protein DEPDC5

0.350

PAK2_HUMAN

Serine/threonine-protein kinase PAK 2

0.350

COX5A_HUMAN

Cytochrome c oxidase subunit 5A, mitochondrial

0.351

CLCN5_HUMAN

H(+)/Cl(-) exchange transporter 5

0.353

DPOG1_HUMAN

DNA polymerase subunit gamma-1

0.354

ACON_HUMAN

Aconitate hydratase, mitochondrial

0.356

PAK3_HUMAN

Serine/threonine-protein kinase PAK 3

0.357

DOT1L_HUMAN

Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.358

SOS2_HUMAN

Son of sevenless homolog 2

0.358

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

0.360

PP2BA_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

0.363

S2536_HUMAN

Solute carrier family 25 member 36

0.363

GYS2_HUMAN

Glycogen [starch] synthase, liver

0.364

RRAGC_HUMAN

Ras-related GTP-binding protein C

0.365

DPP10_HUMAN

Inactive dipeptidyl peptidase 10

0.365

GYS1_HUMAN

Glycogen [starch] synthase, muscle

0.366

SNX12_HUMAN

Sorting nexin-12

0.366

DPP4_HUMAN

Dipeptidyl peptidase 4

0.366

AL4A1_HUMAN

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.367

RICTR_HUMAN

Rapamycin-insensitive companion of mTOR

0.368

SYNC_HUMAN

Asparagine--tRNA ligase, cytoplasmic

0.369

RRAGA_HUMAN

Ras-related GTP-binding protein A

0.369

CUL1_HUMAN

Cullin-1

0.370

SEPT7_HUMAN

Septin-7

0.370

LIS1_HUMAN

Platelet-activating factor acetylhydrolase IB subunit alpha

0.370

AT2C1_HUMAN

Calcium-transporting ATPase type 2C member 1

0.371

GDE_HUMAN

Glycogen debranching enzyme

0.371

HIP1R_HUMAN

Huntingtin-interacting protein 1-related protein

0.372

TM9S2_HUMAN

Transmembrane 9 superfamily member 2

0.372

ACATN_HUMAN

Acetyl-coenzyme A transporter 1

0.373

CMC1_HUMAN

Calcium-binding mitochondrial carrier protein Aralar1

0.374

SEPR_HUMAN

Prolyl endopeptidase FAP

0.374

AVL9_HUMAN

Late secretory pathway protein AVL9 homolog

0.374

STAM1_HUMAN

Signal transducing adapter molecule 1

0.375

PBDC1_HUMAN

Protein PBDC1

0.375

RCC1_HUMAN

Regulator of chromosome condensation

0.376

AT133_HUMAN

Probable cation-transporting ATPase 13A3

0.376

HIP1_HUMAN

Huntingtin-interacting protein 1

0.376

YLAT2_HUMAN

Y+L amino acid transporter 2

0.379

CACP_HUMAN

Carnitine O-acetyltransferase

0.379

ZNT1_HUMAN

Zinc transporter 1

0.379

RAGP1_HUMAN

Ran GTPase-activating protein 1

0.380

DYHC1_HUMAN

Cytoplasmic dynein 1 heavy chain 1

0.380

S2533_HUMAN

Solute carrier family 25 member 33

0.380

SNX3_HUMAN

Sorting nexin-3

0.380

STRP2_HUMAN

Striatin-interacting protein 2

0.380

SRF_HUMAN

Serum response factor

0.381

GSH1_HUMAN

Glutamate--cysteine ligase catalytic subunit

0.381

PP2BC_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

0.381

ARGI2_HUMAN

Arginase-2, mitochondrial

0.382

DYR_HUMAN

Dihydrofolate reductase

0.382

SYRM_HUMAN

Probable arginine--tRNA ligase, mitochondrial

0.383

RHOA_HUMAN

Transforming protein RhoA

0.384

PAN3_HUMAN

PAN2-PAN3 deadenylation complex subunit PAN3

0.384

RRAGD_HUMAN

Ras-related GTP-binding protein D

0.384

PGPS1_HUMAN

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

0.384

FBXW7_HUMAN

F-box/WD repeat-containing protein 7

0.387

ASM_HUMAN

Sphingomyelin phosphodiesterase

0.388

PP2BB_HUMAN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

0.388

S39A9_HUMAN

Zinc transporter ZIP9

0.388

XPA_HUMAN

DNA repair protein complementing XP-A cells

0.389

ARMT1_HUMAN

Protein-glutamate O-methyltransferase

0.389

COR1C_HUMAN

Coronin-1C

0.389

TRM44_HUMAN

Probable tRNA (uracil-O(2)-)-methyltransferase

0.390

PB1_HUMAN

Protein polybromo-1

0.390

CCHL_HUMAN

Cytochrome c-type heme lyase

0.392

DOCK5_HUMAN

Dedicator of cytokinesis protein 5

0.393

STAM2_HUMAN

Signal transducing adapter molecule 2

0.394

UB2G2_HUMAN

Ubiquitin-conjugating enzyme E2 G2

0.396

DPP6_HUMAN

Dipeptidyl aminopeptidase-like protein 6

0.396

COQ7_HUMAN

5-demethoxyubiquinone hydroxylase, mitochondrial

0.396

PLPL6_HUMAN

Neuropathy target esterase

0.397

DCPS_HUMAN

m7GpppX diphosphatase

0.397

MIO_HUMAN

GATOR complex protein MIOS

0.397

LMA2L_HUMAN

VIP36-like protein

0.397

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

0.399

LMAN2_HUMAN

Vesicular integral-membrane protein VIP36

0.399

ATP9A_HUMAN

Probable phospholipid-transporting ATPase IIA

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 93 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy